Effects of Iprodione and Fludioxonil on Glycerol Synthesis and Hyphal Development in<i>Candida albicans</i>

Ochiai, Noriyuki; Fujimura, Masatake; Oshima, Michiyo; Motoyama, Takayuki; Ichiishi, Akihiko; Yamada-Okabe, Hisafumi; Yamaguchi, Isamu

doi:10.1271/bbb.66.2209

Cited by 77 publications

(58 citation statements)

References 46 publications

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“…The work of Rosslenbroich and Stuebler [42] revealed inhibition of spore germination, germ tube elongation, and mycelium growth in Botrytis cinerea, by fludioxonil-related interference in the osmoregulatory signal transmission pathway of this fungus. This finding was supported by Ochiai et al [43] who found that fludioxonil can disturb the CANIKI/COSI signal transduction pathway, leading to the dysfunction of glycerol synthesis and inhibition of hyphae formation in Candida albicans. Recently, Hagiwara et al [44] reported the inhibiting effect of fludioxonil on a large number of genes involved in a two-component signal transduction system, in filamentous fungi.…”

Section: Effects On Signal Transductionsupporting

confidence: 56%

“…Iprodione (3-(3,5-dichlorophenyl)-Nisopropyl-2,4-dioxoimidazolidine-1-carboxamide), a contact dicarboximide fungicide widely used in a variety of crops, inhibits glycerol synthesis and hyphal development by cutting off signal transduction [43], as does fludioxonil. Iprodione can modify the structure of the soil bacterial community, as reported in a recent research [24].…”

Section: Effects On Signal Transductionmentioning

confidence: 99%

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Fungicide: Modes of Action and Possible Impact on Nontarget Microorganisms

et al. 2011

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Fungicides have been used widely in order to control fungal diseases and increase crop production. However, the effects of fungicides on microorganisms other than fungi remain unclear. The modes of action of fungicides were never well classified and presented, making difficult to estimate their possible nontarget effects. In this paper, the action modes and effects of fungicides targeting cell membrane components, protein synthesis, signal transduction, respiration, cell mitosis, and nucleic acid synthesis were classified, and their effects on nontarget microorganisms were reviewed. Modes of action and potential non-target effects on soil microorganisms should be considered in the selection of fungicide in order to protect the biological functions of soil and optimize the benefits derived from fungicide use in agricultural systems.

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Section: Effects On Signal Transductionsupporting

confidence: 56%

Section: Effects On Signal Transductionmentioning

confidence: 99%

Fungicide: Modes of Action and Possible Impact on Nontarget Microorganisms

et al. 2011

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“…In their N terminus, they contain a poly-HAMP module, which is essential for osmosensing as well as cell death upon exposure to the antifungal agent fludioxonil (2,6,9,(33)(34)(35)(36). DhNik1p is a typical molecule of this class and contains five HAMP domains and four HAMP-like linkers (Fig.…”

Section: Discussionmentioning

confidence: 99%

Differential Role of HAMP-like Linkers in Regulating the Functionality of the Group III Histidine Kinase DhNik1p

Kaur

Singh

Rathore

et al. 2014

Journal of Biological Chemistry

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“…Exposure of several plant-pathogenic fungi to fludioxonil, including Colletotrichum lagenarium, Botrytis cinerea and Cochliobolus heterostrophus, activates the Hog1 MAPK homologue and inhibits fungal growth (Kojima et al, 2004). In Candida albicans and N. crassa, fludioxonil treatment seems to induce excessive intracellular glycerol accumulation (Fujimura et al, 2000a;Ochiai et al, 2002;Zhang et al, 2002).…”

Section: Introductionmentioning

confidence: 99%

Calcineurin, Mpk1 and Hog1 MAPK pathways independently control fludioxonil antifungal sensitivity in Cryptococcus neoformans

2006

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Fludioxonil is employed as an agricultural fungicide to control plant-pathogenic fungi such as Botrytis cinerea. Cryptococcus neoformans is a basidiomycetous human fungal pathogen that causes fatal disease in immunocompromised hosts. This paper demonstrates that three different signalling cascades regulate sensitivity of C. neoformans to fludioxonil. Fludioxonil inhibited growth of the serotype A sequence reference strain H99 but not that of the sequenced serotype D strain JEC21. In the drug-sensitive wild-type strain, fludioxonil exposure activated the Hog1 osmosensing pathway, and hog1D mutations conferred fludioxonil resistance. Fludioxonil treatment caused cell growth inhibition following cell swelling and cytokinesis defects in the sensitive wild-type but not in a hog1D mutant strain, suggesting that Hog1 activation results in morphological cellular defects. Fludioxonil exerted a fungistatic effect on the wild-type strain H99, but exhibited fungicidal activity against calcineurin mutant strains, indicating that the calcineurin pathway contributes to drug resistance in this fungus. Combination of fludioxonil and the calcineurin inhibitor FK506 synergistically inhibited C. neoformans growth. mpk1D MAPK mutant strains exhibited fludioxonil hypersensitivity, indicating that this pathway also contributes to drug resistance. These studies provide evidence that the broad-spectrum antifungal drug fludioxonil exerts its action via activation of the Hog1 MAPK pathway and provide insight into novel targets for synergistic antifungal drug combinations.

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Effects of Iprodione and Fludioxonil on Glycerol Synthesis and Hyphal Development inCandida albicans

Cited by 77 publications

References 46 publications

Fungicide: Modes of Action and Possible Impact on Nontarget Microorganisms

Fungicide: Modes of Action and Possible Impact on Nontarget Microorganisms

Differential Role of HAMP-like Linkers in Regulating the Functionality of the Group III Histidine Kinase DhNik1p

Calcineurin, Mpk1 and Hog1 MAPK pathways independently control fludioxonil antifungal sensitivity in Cryptococcus neoformans

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