Effects of Ipomoea aquatica Forsk. in cyclophosphamide induced dyslipidaemia in albino rats

Das, Rajesh; Devi, Khuraijam Sucheta; Dutta, Sayeri; Das, Ananya; Das, Prasenjit; Devi, Kh Krishna Pramodini

doi:10.18203/2319-2003.ijbcp20174799

Cited by 3 publications

(5 citation statements)

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“…One of the key findings of the current investigation was that CYCP elicited significant disruption of lipid homeostasis characterized by up-regulation in the mean concentrations of erythrocyte cholesterol, triacylglycerol, phospholipids, non-esterified fatty, and cholesterol-phospholipids molar ratio. This observation is characteristic changes that have been reported during xenobiotics, including CYCP administration [ [64] , [65] , [66] , [67] ].…”

Section: Discussionsupporting

confidence: 53%

“…The observed CYCP-induced hypertriacylglycerolemia in this study could result from either increased VLDL production or decreased VLDL clearance [ 68 ]. Increased cholesterol is equally associated with increased cholesterol anabolism and/or decreased cholesterol catabolism [ 65 ]. The current research demonstrated a CYCP-induced significant increase in phospholipids.…”

Section: Discussionmentioning

confidence: 99%

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Naringin prevents cyclophosphamide-induced erythrocytotoxicity in rats by abrogating oxidative stress

et al. 2021

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Section: Discussionsupporting

confidence: 53%

Section: Discussionmentioning

confidence: 99%

Naringin prevents cyclophosphamide-induced erythrocytotoxicity in rats by abrogating oxidative stress

et al. 2021

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“…Senthilkumar et al [5] reported that treatment of rats with 150 mg/kg of CPA for 2 days caused a significant alterations in serum cholesterol and none significant changes were observed in serum triglycerides. CP administration significantly (P<0.05) increased the levels of triglyceride, total cholesterol, LDL-cholesterol and decreased the level of HDL-cholesterol in toxic group compared to normal group [4]. 5-FU is widely used in the treatment of a range of cancers, including colorectal and breast cancers, and cancers of the aerodigestive tract.…”

Section: Introductionmentioning

confidence: 97%

“…Cyclophosphamide (CP) is commonly used as anticancer and immuno suppressant agent. It is mainly used for ovarian cancer, breast cancer, chronic lymphocytic leukemia, non-Hodgkin's lymphoma, neuroblastoma, soft tissue sarcoma, rhabdomyosarcoma, Wilms' tumor, and immunosuppressant agent [3,4]. It induces hyperlipidemia and myocardium damage [4].…”

Section: Introductionmentioning

confidence: 99%

“…It is mainly used for ovarian cancer, breast cancer, chronic lymphocytic leukemia, non-Hodgkin's lymphoma, neuroblastoma, soft tissue sarcoma, rhabdomyosarcoma, Wilms' tumor, and immunosuppressant agent [3,4]. It induces hyperlipidemia and myocardium damage [4]. Senthilkumar et al [5] reported that treatment of rats with 150 mg/kg of CPA for 2 days caused a significant alterations in serum cholesterol and none significant changes were observed in serum triglycerides.…”

Section: Introductionmentioning

confidence: 99%

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Antidyslipidemic Effect of 5-Fluorouracil against Cyclophosphamide-Induced Dyslipidemia in Male Albino Rats

Azab¹,

Yahya²,

Attia³

et al. 2022

JCRR

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Background: Cyclophosphamide (CPA) is a drug with a wide spectrum of clinical uses. It is commonly used as anticancer and immuno suppressant agent. It induces hyperlipidemia and myocardium damage. 5-FU is widely used in the treatment of a range of cancers. 5-FU in combination with other chemotherapeutic agents improves response rates and survival in breast and head and neck cancers. Objectives: The present study aimed to evaluate the antidyslipidemic effect of 5-fluorouracil against dyslipidemia induced by cyclophosphamide in male albinorats. Materials and Methods: Twenty-eight male adult rats were grouped randomly into four groups (n=5 for each group). Group II cyclophosphamide (CPA): Cyclophosphamide at a dose of 10 mg/kg day by day through i.p. to rats for 14 days. Group III Fluorouracil (5-FU): 5-Fluorouracil at a dose of 10 mg/kg day by day in saline was given through i.p. to rats for 14 days. Group IV (CPA+5-FU): Rats were given CPA followed by 5-FU at a dose of 10 mg/kg per day (day by day) through i.p. to rats for 14 days. At the end of the experimental period, rats were anesthetized using light ether. Blood samples were taken and prepared for biochemical measurements. Results: Intraperitoneal administration of CPA or 5-FU resulted in a significant increase in the levels of serum lipids. The cholesterol, Triglyceride, and LDL levels in serum of CPA or 5-FU treated rats were significantly increased when compared to controls. When CPA was administered followed by 5-FU prevented the increase in serum lipid levels highlighting its hypolipidemic role as antagonism. Also, a marked decrease in HDL cholesterol was noted in CPA treated rats. These changes produced by CPA to serum levels of HDL were normalized when 5-FU is given to the treated rats compared to CPA administered rats. Conclusion: It could be concluded that treatment of rats with CPA induced dyslipidemia. However, 5-FU and CPA combination could produce a significant amelioration in the dyslipidemic changes, and it may be considered as a potentially useful candidate in the combination chemotherapy with CPA to prevent dyslipidemia. Future work should consider combined chemotherapy regimens, as two or more mechanisms of action of chemotherapeutic drugs could be more powerful than one mechanism.

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Potential Effects of Ipomoea reptans Poir. Extract on LDL, HDL levels and liver Histopathology

Rahma,

Purnomo

2023

J. Biomed. Transl. Res.

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Background: Ipomoea reptans Poir. extract has been known to have antioxidant, antihypertensive, antidiabetic and anti-obesity activities. The content of the secondary compounds antioxidant in the extract is believed to play an important role in this mechanism also often reported that have regulating cholesterol levels.Objective: This study aims to investigate the antioxidant activity of I. reptans extract on changes in low-density lipoprotein (LDL) and high-density lipoprotein (HDL) and liver histopathology in animal models of hypercholesterolemia that treated with I. reptans extract.Methods: This research was an in vivo experimental study using mice. Twenty five wistar rats were randomly divided into 5 groups: normal group (N), hypercholesterolemic group (Chol), I. reptans extract group at a dose of 200 mg/kg BW, 300 mg/kg BW and 400 mg/kgBB (IE 200; IE 300, and IE 400). In the Chol and IE groups, the rats were induced by cholesterol in the form of a mixture of quail egg yolk and animal oil for 21 days. Then, continued with therapy with I. reptans extract in the IE group only according to their respective doses for 14 days. All rats were then dissected and blood serum taken for analysis of LDL and HDL levels using a colorimetric kit, and liver organs were also taken for histopathological analysis with hematoxylin-Eosin (HE) staining. All research data were analyzed using the Shapiro-Wilk normality test and the Levene's homogeneity test. If the data obtained is normally distributed, it is continued with the One-way Anova comparative test and the LSD post hoc test. If the data obtained is not normally distributed, continue with the Kruskal-Wallis and Mann-Whitney tests.Results: The results showed that the average LDL levels in the N, Chol, IE 200, IE 300 and IE 400 groups were 8.56 ± 1.36, 29.9 ± 1.05, 25.22 ± 4.72, 9.12 ± 0.72, and 9.22 ± 0.77 mg/dL, while the average HDL levels in the were 38.1 ± 2.24, 15.92 ± 4.39, 33.4 ± 5.91, 36.92 ± 0.47, and 42.82 ± 3.27 mg/dL respectively. Liver histopathology in the IE 300 group showed reduced fatty degeneration compared to the Chol group.Conclusion: It can be concluded that the administration of I.reptans extract in hypercholesterolemia rats was able to ameliorates LDL and HDL levels, and improve liver histopathology.

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Effects of Ipomoea aquatica Forsk. in cyclophosphamide induced dyslipidaemia in albino rats

Cited by 3 publications

References 4 publications

Naringin prevents cyclophosphamide-induced erythrocytotoxicity in rats by abrogating oxidative stress

Naringin prevents cyclophosphamide-induced erythrocytotoxicity in rats by abrogating oxidative stress

Antidyslipidemic Effect of 5-Fluorouracil against Cyclophosphamide-Induced Dyslipidemia in Male Albino Rats

Potential Effects of Ipomoea reptans Poir. Extract on LDL, HDL levels and liver Histopathology

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