Effects of Ionizing Radiation on Choline Chloride and its Analogs¹

Abstract

Choline chloride and six analogs have been exposed in the dry, crystalline state to high-energy electron and gamma radiation. This investigation hat confirmed the abnormal radiation sensitivity of choline chloride, Its G values (molecules decomposed/100 ev) were found to be: e"-radiation, 20; y-radtation, 175. These high values indicate a chain mechanism for the solid-stale reaction. The G values for the choline analogs were found to range from I to 18 for the electron Irradiations and from • to 52 for the gamma irradiations. Betaine hydrochloride approaches choline chloride in instability toward high-energy electrons but is far more stable in the presence of y-rays.

Electron spin resonance of a γ-irradiated single crystal of carbamylcholine chloride

“…The first term represents the interaction of the electron spin with the proton spins (Ii = :). The The variations in the spectra indicate that the two a-protons are equivalent, and their hyperfine coupling constant is isotropic with a value of 27.6 G. The /?-proton (2) coupling constant is given by9 where 0 is the angle between the C,-H, bond and the p orbital direction, projected perpendicular to the C,-C, bond. Bo is a constant and includes the contributions from spin density which arise from conformation-independent mechanisms, in particular spin (3) Replacing the very pronounced value^,^.^* B, = (r3.5 G and B, = 50 G in eqn (3), we obtain a, = 28.5 Gs; and this is in good agreement with our experimental result, 27.6 G. Hence we conclude that the /?-protons in the -CHCH2-radical rotate about the C,-C, bond.…”

Electron Paramagnetic Resonance of Gamma Irradiation Damage Centres in Acetyl and Carbamyl-β-Methyl Choline Chloride

“…The radiation sensitivity of biologically important choline derivatives has long been recognised. 1,2 Selective deuteration of choline chloride has been employed to establish the localisation of the unpaired electron in the radical using EPR techniques. 3 Although the spectra were not well resolved they were attributed to the radical Ċ H 2 CH 2 OH.…”

Review: Self‐radiolysis of compounds containing tritium and carbon‐14

“…Similar to [ 3 H]TCDD, decomposition of [13‐ 3 H]mianserin results in the formation of an aryl cation, which reacts with the benzene to form unlabeled 13‐phenylmianserin (Figure 1). 90 [ 14 C]Choline chloride undergoes rapid self‐decomposition when stored as a solid at ambient temperature forming [ 14 C]trimethyl amine and acetaldehyde via carbon–carbon bond cleavage 49,74,75,91,92 . When stored at −80°C, however, [ 14 C]choline chloride is stable showing no decomposition when stored up to 11 months 51,87 .…”