Effects of Ionizing Radiation on Biopolymers for Applications as Biomaterials

Hara, Masayuki

doi:10.1007/s44174-022-00049-6

Cited by 5 publications

(3 citation statements)

References 112 publications

(160 reference statements)

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“…Both direct and indirect effects of ionizing radiation result in the increase in polymer degradation (Figure 4). This process reduces biocompatibility as well as exposes the drug or other molecules to be exposed to radiation (Hara, 2022). Additionally, biopolymers can create ROS which can mitigate the effect of radioprotection.…”

Section: Applications/ Comments Referencesmentioning

confidence: 99%

Nanotechnology enabled radioprotectants to reduce space radiation‐induced reactive oxidative species

Babu

Pawar

Mittal

et al. 2023

WIREs Nanomed Nanobiotechnol

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Interest in space exploration has seen substantial growth following recent launch and operation of modern space technologies. In particular, the possibility of travel beyond low earth orbit is seeing sustained support. However, future deep space travel requires addressing health concerns for crews under continuous, longer‐term exposure to adverse environmental conditions. Among these challenges, radiation‐induced health issues are a major concern. Their potential to induce chronic illness is further potentiated by the microgravity environment. While investigations into the physiological effects of space radiation are still under investigation, studies on model ionizing radiation conditions, in earth and micro‐gravity conditions, can provide needed insight into relevant processes. Substantial formation of high, sustained reactive oxygen species (ROS) evolution during radiation exposure is a clear threat to physiological health of space travelers, producing indirect damage to various cell structures and requiring therapeutic address. Radioprotection toward the skeletal system components is essential to astronaut health, due to the high radio‐absorption cross‐section of bone mineral and local hematopoiesis. Nanotechnology can potentially function as radioprotectant and radiomitigating agents toward ROS and direct radiation damage. Nanoparticle compositions such as gold, silver, platinum, carbon‐based materials, silica, transition metal dichalcogenides, and ceria have all shown potential as viable radioprotectants to mitigate space radiation effects with nanoceria further showing the ability to protect genetic material from oxidative damage in several studies. As research into space radiation‐induced health problems develops, this review intends to provide insights into the nanomaterial design to ameliorate pathological effects from ionizing radiation exposure.This article is categorized under: Therapeutic Approaches and Drug Discovery > Emerging Technologies Nanotechnology Approaches to Biology > Nanoscale Systems in Biology Nanotechnology Approaches to Biology > Cells at the Nanoscale Therapeutic Approaches and Drug Discovery > Nanomedicine for Oncologic Disease

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Section: Applications/ Comments Referencesmentioning

confidence: 99%

Nanotechnology enabled radioprotectants to reduce space radiation‐induced reactive oxidative species

Babu

Pawar

Mittal

et al. 2023

WIREs Nanomed Nanobiotechnol

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“…The advantage of mutations in plants is that changes occur in the genotypic structure so that species variability increases and can support plant adaptability to various selection pressures (Salas, R. A et al, 2013; Brain et al, n.d.) These mutations can be induced by physical mutagenic agents such as ionizing radiation (X-rays and gamma rays), nonionizing radiation (ultraviolet), and cellular radiation (protons, neutrons, alpha, and beta particles) (Ludovici, et. al., 2022;Gian et al, 2022;Hara, 2023).…”

Section: Introductionmentioning

confidence: 99%

Testing the Quality of Chilli Seeds Resulting from Gamma-Ray Irradiation and Genetic Diversity

Maulana,

Muhammad Arief Nasution,

Andi Muhibuddin

et al. 2024

bjbs

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Gamma-ray irradiation is used to improve seed germination and plant seedling growth and is a way to increase plant genetic diversity. This research aims to (1) analyze the response of seed irradiation to germination and (2) identify genetic diversity. This study used a Randomized Group Design (RAK), which consisted of 6 treatment levels used, namely R0 = 0 Gry (control), R1 = 100 Gy, R2 = 200 Gy, R3 = 300 Gy, R4 = 400 Gy and R5 = 500 Gy. Each treatment had 20 replications, so there were 100 experimental units. Based on the results of this research show that the reticulum emergence test can be used as a basis for determining the germination and vigor of mutant and non-mutant chili seeds, while the use of the special molecular marker RAPD can be used to determine the level of diversity for mutant chili plants.

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“…Research on the impact of ionizing radiation on packaging made of various materials, including plastic, has been carried out for many years, but there are few reports on biodegradable materials [ 50 , 51 ]. A prerequisite for considering the application potential of new solutions in radiation technologies is the identification of the possible changes caused by ionizing radiation.…”

Section: Introductionmentioning

confidence: 99%

Characterization of Biodegradable Food Contact Materials under Gamma-Radiation Treatment

et al. 2023

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Radiation is an example of one of the techniques used for pasteurization and sterilization in various packaging systems. There is a high demand for the evaluation of the possible degradation of new composites, especially based on natural raw materials. The results of experimental research that evaluated the impact of radiation technology on biodegradable and compostable packaging materials up to 40 kGy have been presented. Two commercially available flexible composite films based on aliphatic–aromatic copolyesters (AA) were selected for the study, including one film with chitosan and starch (AA-CH-S) and the other with thermoplastic starch (AA-S). The materials were subjected to the influence of ionizing radiation from 10 to 40 kGy and then tests were carried out to check their usability as packaging material for the food industry. The results showed that the mechanical properties of AA-S films improved due to the radiation-induced cross-linking processes, while in the case of AA-CH-S films, a considerable decrease in the elongation at break was observed. The results also showed a decrease in the WVTR in the case of AA-S and no changes in barrier properties in the case of AA-CH-S. Both materials revealed no changes in the odor analyzed by sensory analysis. In the case of the AA-S films, the higher the radiation dose, the faster the biodegradation rate. In the case of the AA-CH-S film, the radiation did not affect biodegradation. The performed research enables the evaluation of the materials intended for direct contact with food. AA-CH-S was associated with unsatisfactory parameters (exceeding the overall migration limit and revealing color change during storage) while AA-S showed compliance at the level of tests carried out. The study showed that the AA-CH-S composite did not show a synergistic effect due to the presence of chitosan.

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Effects of Ionizing Radiation on Biopolymers for Applications as Biomaterials

Cited by 5 publications

References 112 publications

Nanotechnology enabled radioprotectants to reduce space radiation‐induced reactive oxidative species

Nanotechnology enabled radioprotectants to reduce space radiation‐induced reactive oxidative species

Testing the Quality of Chilli Seeds Resulting from Gamma-Ray Irradiation and Genetic Diversity

Characterization of Biodegradable Food Contact Materials under Gamma-Radiation Treatment

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