Effects of Ion Radiation on Cells and Tissues

Scholz, M.

doi:10.1007/3-540-45668-6_4

Cited by 35 publications

(24 citation statements)

References 140 publications

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“…In the case of X-rays the ionization events are randomly distributed throughout the volume of the cell nucleus and only small variations in the cell nuclear doses occur. In contrast, when particles are applied, the dose is inhomogeneously deposited with respect to the dose inside a particle track and the number of traversals per nucleus (e.g., Scholz 2003). The number of cell nuclei that receive ionizations depends on the track diameter and the particle fluence.…”

Section: Effect Of High Let Exposure On the Cell Cycle Progression Ofmentioning

confidence: 95%

“…The rise has been attributed to a higher complexity and lower reparability of the induced DNA lesions, while the decrease has been explained by the production of more damages than can be expressed by the biological system (overkill phenomenon). For a more detailed discussion see Kraft (1999) and Scholz (2003).…”

Section: Effect Of High Let Exposure On the Cell Cycle Progression Ofmentioning

confidence: 99%

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Cell cycle arrest and aberration yield in normal human fibroblasts. II: Effects of 11 MeV u⁻¹C ions and 9.9 MeV u⁻¹Ni ions

Tenhumberg

Gudowska–Nowak

Nasonova

et al. 2007

International Journal of Radiation Biology

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Section: Effect Of High Let Exposure On the Cell Cycle Progression Ofmentioning

confidence: 95%

Section: Effect Of High Let Exposure On the Cell Cycle Progression Ofmentioning

confidence: 99%

Cell cycle arrest and aberration yield in normal human fibroblasts. II: Effects of 11 MeV u⁻¹C ions and 9.9 MeV u⁻¹Ni ions

Tenhumberg

Gudowska–Nowak

Nasonova

et al. 2007

International Journal of Radiation Biology

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“…20) With the appropriate beam delivery techniques, the effective region can essentially be focussed to the tumor volume. 20,21) Investigations into the effects of carbon ion irradiation are becoming increasingly pertinent in light of the rapidly growing interest in this type of radiotherapy. For example, in a few years Europe will host many hospitalbased centers that offer ion therapy.…”

Section: Introductionmentioning

confidence: 99%

Differential Effects of Irradiation with Carbon Ions and X-Rays on Macrophage Function

Conrad

Ritter

Fournier

et al. 2009

JRR

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Macrophages are potent elicitors of inflammatory reactions that can play both positive and negative roles in radiotherapy. While several studies have investigated the effects of X-rays or gamma-rays on macrophages, virtually no work has been done on the responses of these cells to irradiation with carbon ions. Investigations into the effects of carbon ion irradiation are of particular interest in light of the fact that this type of radiation is being used increasingly for cancer therapy. In the present investigation we compared the effects of 250 kV X-rays with those of 9.8 MeV/u carbon ions on RAW 264.7 macrophages over a wide range of radiation doses. Macrophage functions including vitality, phagocytic activity, production of the proinflammatory cytokines IL-1beta and TNFalpha and production of nitric oxide (NO) were measured. In comparison to lymphocytes and fibroblasts, macrophages showed only a small decrease in vitality after irradiation with either X-rays or carbon ions. Proinflammatory cytokines and NO were induced in macrophages by LPS but not by irradiation alone. X-rays or carbon ions had little modulating effect on LPS-induced TNFalpha production. However, LPS-induced NO increased in a dose dependent manner up to 6-fold after carbon ion irradiation, while X-ray irradiation did not have this effect. Carbon ion irradiation mediated a concomitant decrease in IL-1beta production. Carbon ions also had a greater effect than X-rays in enhancing the phagocytic activity of macrophages. These results underscore the greater potential of carbon ion irradiation with regard to radiobiological effectiveness.

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“…H umans unavoidably are exposed to radiation that comprises both sparsely ionizing radiation (eg, γ- or X-rays) and densely ionizing radiation (eg, α-particles) [ 1 ]. Sparsely ionizing radiation is characterized by a more homogeneous dose distribution of relatively small energy depositions, whereas densely ionizing radiation exhibits a heterogeneous dose distribution with high local energy depositions.…”

Section: Introductionmentioning

confidence: 99%

Ionizing Radiation Impacts on Cardiac Differentiation of Mouse Embryonic Stem Cells

Helm

Arrizabalaga

Pignalosa

et al. 2016

Stem Cells and Development

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Little is known about the effects of ionizing radiation on the earliest stages of embryonic development although it is well recognized that ionizing radiation is a natural part of our environment and further exposure may occur due to medical applications. The current study addresses this issue using D3 mouse embryonic stem cells as a model system. Cells were irradiated with either X-rays or carbon ions representing sparsely and densely ionizing radiation and their effect on the differentiation of D3 cells into spontaneously contracting cardiomyocytes through embryoid body (EB) formation was measured. This study is the first to demonstrate that ionizing radiation impairs the formation of beating cardiomyocytes with carbon ions being more detrimental than X-rays. However, after prolonged culture time, the number of beating EBs derived from carbon ion irradiated cells almost reached control levels indicating that the surviving cells are still capable of developing along the cardiac lineage although with considerable delay. Reduced EB size, failure to downregulate pluripotency markers, and impaired expression of cardiac markers were identified as the cause of compromised cardiomyocyte formation. Dysregulation of cardiac differentiation was accompanied by alterations in the expression of endodermal and ectodermal markers that were more severe after carbon ion irradiation than after exposure to X-rays. In conclusion, our data show that carbon ion irradiation profoundly affects differentiation and thus may pose a higher risk to the early embryo than X-rays.

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Effects of Ion Radiation on Cells and Tissues

Cited by 35 publications

References 140 publications

Cell cycle arrest and aberration yield in normal human fibroblasts. II: Effects of 11 MeV u⁻¹C ions and 9.9 MeV u⁻¹Ni ions

Cell cycle arrest and aberration yield in normal human fibroblasts. II: Effects of 11 MeV u⁻¹C ions and 9.9 MeV u⁻¹Ni ions

Differential Effects of Irradiation with Carbon Ions and X-Rays on Macrophage Function

Ionizing Radiation Impacts on Cardiac Differentiation of Mouse Embryonic Stem Cells

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Effects of Ion Radiation on Cells and Tissues

Cited by 35 publications

References 140 publications

Cell cycle arrest and aberration yield in normal human fibroblasts. II: Effects of 11 MeV u−1C ions and 9.9 MeV u−1Ni ions

Cell cycle arrest and aberration yield in normal human fibroblasts. II: Effects of 11 MeV u−1C ions and 9.9 MeV u−1Ni ions

Differential Effects of Irradiation with Carbon Ions and X-Rays on Macrophage Function

Ionizing Radiation Impacts on Cardiac Differentiation of Mouse Embryonic Stem Cells

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Cell cycle arrest and aberration yield in normal human fibroblasts. II: Effects of 11 MeV u⁻¹C ions and 9.9 MeV u⁻¹Ni ions

Cell cycle arrest and aberration yield in normal human fibroblasts. II: Effects of 11 MeV u⁻¹C ions and 9.9 MeV u⁻¹Ni ions