Effects of intravitreal ropivacaine on retinal thickness and integrity in the guinea pig

Olmez, Gonul; Cakmak, Sevin Soker; Söker, Sevda; Nergız, Yusuf; Yildiz, Fethin

doi:10.1016/j.curtheres.2005.08.005

Cited by 6 publications

(7 citation statements)

References 18 publications

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“…In line with this result, after intravitreally injecting lidocaine (concentration < 0.2%), no obvious functional or histological changes were noted in the cornea or retina of rabbits[ 9 ]. Olmez et al [ 10 ] explored the effect of intravitreal ropivacaine on retinal thickness and integrity in animal models. More extensive retinal thinning was observed in eyes injected with 0.1 mL of 1% ropivacaine, compared with eyes injected with 0.1 mL of 0.75% or 0.5% ropivacaine[ 10 ].…”

Section: Discussionmentioning

confidence: 99%

“…Olmez et al [ 10 ] explored the effect of intravitreal ropivacaine on retinal thickness and integrity in animal models. More extensive retinal thinning was observed in eyes injected with 0.1 mL of 1% ropivacaine, compared with eyes injected with 0.1 mL of 0.75% or 0.5% ropivacaine[ 10 ]. The mean total retinal thickness was lower in the ropivacaine group than in controls.…”

Section: Discussionmentioning

confidence: 99%

“…The mean total retinal thickness was lower in the ropivacaine group than in controls. Histopathological analysis revealed structural abnormalities in the retinas of eyes that received 0.1 mL of 0.75% or 1% ropivacaine[ 10 ]. The authors hypothesized that the toxic effects of intravitreal ropivacaine on animal retinas were concentration dependent[ 10 ].…”

Section: Discussionmentioning

confidence: 99%

“…Histopathological analysis revealed structural abnormalities in the retinas of eyes that received 0.1 mL of 0.75% or 1% ropivacaine[ 10 ]. The authors hypothesized that the toxic effects of intravitreal ropivacaine on animal retinas were concentration dependent[ 10 ]. In this situation, surgical options, such as PPV, should be considered to minimize the retinal toxicity caused by medication.…”

Section: Discussionmentioning

confidence: 99%

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Inadvertent globe penetration during retrobulbar anesthesia: A case report

Dai¹,

Sun²,

Gong³

2021

WJCC

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BACKGROUND To report the possible reasons for needle perforation and complications related to perforation, as well as the clinical management of subretinal hemorrhage (SRH) during retrobulbar injection. CASE SUMMARY A 65-year-old female was scheduled to undergo pars plana vitrectomy (PPV) in her left eye for rhegmatogenous retinal detachment (RRD). During retrobulbar anesthesia, needle perforation of the globe occurred. Massive SRH in the inferotemporal quadrant together with vitreous hemorrhage were observed. The patient underwent PPV combined with retinotomy for removal of the massive SRH. After earlier surgical intervention, successful reattachment of the retina was achieved. CONCLUSION Inadvertent globe penetration during retrobulbar anesthesia is associated with a poor prognosis and may result in blindness. Timely detection and earlier intervention may be beneficial.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Inadvertent globe penetration during retrobulbar anesthesia: A case report

Dai¹,

Sun²,

Gong³

2021

WJCC

View full text Add to dashboard Cite

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“…[ 12–14 ] In addition, in vitro toxic effects of intravitreal local anesthetic administration on the retina have been reported. [ 15,16 ]…”

Section: Introductionmentioning

confidence: 99%

Inflammatory signal transduction pathways induced by prilocaine toxicity in cultured ARPE‐19 cells

Öztüzün

Çeker

Yılmaz

et al. 2023

J Biochem & Molecular Tox

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Prilocaine (PRL) is a common local anesthetic. Despite the successful use of regional anesthesia for intraocular surgery, there are associated side effects that may affect the retina in case of accidental intravitreal injection. This study examined the signal transduction pathways activated by PRL toxicity and determined the protective role of nitric oxide synthase‐2 (NOS2) inhibition in cultured human‐derived retinal pigment epithelial cells (ARPE‐19). Toxicity analysis was performed using the 3‐(4,5‐dimethylthiazol‐2‐yl)‐2,5‐diphenyl tetrazolium bromide assay to detect the toxic dose of PRL and protective effectiveness of asperglaucide (ASP), an NOS2 inhibitor. Nuclear factor kappa B p65 (NF‐κB p65), phosphorylated NF‐κB p65, phospho‐protein kinase B (AKT), NOS2, nitrotyrosine, and cleaved caspase‐3 protein levels were evaluated by immunofluorescence staining and/or western blot analysis. Interleukin‐6 (IL‐6) and nitrated protein levels were quantified using an immunoassay, whereas caspase‐3 activity and nitrite/nitrate levels were measured using a fluorometric method. A significant increase in NF‐κB p65, and phosphorylated NF‐κB p65 and AKT levels due to PRL toxicity was observed. Similarly, IL‐6, NOS2, nitrite/nitrate, and nitrotyrosine levels were significantly higher in PRL‐treated cells than in control cells. Application of ASP to PRL‐treated cells reduced NF‐κB p65, and phosphorylated NF‐κB p65 and AKT to basal levels. IL‐6, NOS2, nitrite/nitrate, and nitrotyrosine levels also considerably decreased following ASP treatment in cells experiencing PRL‐induced toxicity. Moreover, the caspase‐3‐dependent apoptotic pathway was not activated. Our results indicate that ASP could ameliorate PRL‐induced activation of NF‐κB p65 that led to inflammation in cultured ARPE‐19 cells.

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Prospective insulin-based ophthalmic delivery systems for the treatment of dry eye syndrome and corneal injuries

Cruz-Cazarim

Cazarim

Ogunjimi

et al. 2019

European Journal of Pharmaceutics and Biopharmaceutics

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Effects of intravitreal ropivacaine on retinal thickness and integrity in the guinea pig

Abstract: In this small experimental study, ropivacaine had concentration-dependent toxic effects on guinea pig retinas.

Cited by 6 publications

References 18 publications

Inadvertent globe penetration during retrobulbar anesthesia: A case report

Inadvertent globe penetration during retrobulbar anesthesia: A case report

Inflammatory signal transduction pathways induced by prilocaine toxicity in cultured ARPE‐19 cells

Prospective insulin-based ophthalmic delivery systems for the treatment of dry eye syndrome and corneal injuries

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