Effects of Intravenously Infused Fish Oil on Platelet Fatty Acid Phospholipid Composition and on Platelet Function in Postoperative Trauma

Roulet, M.; Frascarolo, Philippe; Pilet, Marianne; Chapuis, G

doi:10.1177/0148607197021005296

Cited by 60 publications

(36 citation statements)

References 30 publications

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“…It was reported that reduction in platelet aggregation can be modified by increasing omega-3 long-chain fatty acid content of platelet phospholipids in humans [18] . In a randomized, controlled double-blind study, Heller AR and colleagues [19,20] demonstrated that no coagulation and platelet abnor malities are evoked by fish oil supplementation as high as 0.2 g/kg per day for five postoperative days.…”

Section: Discussionmentioning

confidence: 99%

Impact of postoperative omega-3 fatty acid-supplemented parenteral nutrition on clinical outcomes and immunomodulations in colorectal cancer patients

Liang¹,

Wang²,

Ye³

et al. 2008

WJG

120

143

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AIM:To investigate the effect of omega-3 fatty acid parenteral supplementation postoperatively on clinical outcomes and immunomodulation in colorectal cancer patients. METHODS:Forty-two patients undergoing radical colorectal cancer resection with an indication for total parenteral nutrition postoperatively were enrolled in this prospective, double-blind, randomized, controlled study. Patients received total parenteral nutrition supplemented with either soybean oil (LCT; Intralipid CONCLUSION:Postoperative supplementation of omega-3 fatty acids may have a favorable effect on the outcomes in colorectal cancer patients undergoing radical resection by lowering the magnitude of inflammatory responses and modulating the immune response.

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Section: Discussionmentioning

confidence: 99%

Impact of postoperative omega-3 fatty acid-supplemented parenteral nutrition on clinical outcomes and immunomodulations in colorectal cancer patients

Liang¹,

Wang²,

Ye³

et al. 2008

WJG

120

143

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show abstract

“…For example, infusion of a fish oilcontaining lipid emulsion into postoperative patients resulted in an increased capacity of stimulated blood leukocytes to generate LTC 4 at day 6 postoperation (48). Fish oil infusion was also found to decrease the production of TXB 2 and to increase the production of TXA 3 by platelets from patients postsurgery (49). In another study, patients received either an MCT-long chain triacylglycerol mix or this mix also containing fish oil for 5 days postsurgery (50).…”

Section: Studies Of Fish Oil-containing Parenteral Nutrition In Surgimentioning

confidence: 93%

Long-chain n-3 fatty acids and inflammation: potential application in surgical and trauma patients

Calder

2003

Braz J Med Biol Res

156

120

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“…Intravenous infusion of lipid emulsions containing fish oil into patients following gastrointestinal surgery altered the fatty acid composition of plasma (61)(62)(63)(64) , platelet (65) and erythrocyte (64) phospholipids: typically EPA content was increased. Intravenous infusion of a lipid emulsion containing fish oil into patients for 5 d following gastrointestinal surgery also altered the fatty acid composition of leucocytes: EPA content was increased 2 .…”

Section: Studies Of Parenteral Fish Oil In Surgical Patientsmentioning

confidence: 99%

Rationale and use of n-3 fatty acids in artificial nutrition

Calder

2010

Proc. Nutr. Soc.

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Lipids traditionally used in artificial nutrition are based on n-6 fatty acid-rich vegetable oils like soyabean oil. This may not be optimal because it may present an excessive supply of linoleic acid. One alternative to the use of soyabean oil is its partial replacement by fish oil, which contains n-3 fatty acids. These fatty acids influence inflammatory and immune responses and so may be useful in particular situations where those responses are not optimal. Fish oil-containing lipid emulsions have been used in parenteral nutrition in adult patients post-surgery (mainly gastrointestinal). This has been associated with alterations in patterns of inflammatory mediators and in immune function and, in some studies, a reduction in length of intensive care unit (ICU) and hospital stay. Perioperative administration of fish oil may be superior to post-operative. Parenteral fish oil has been used in critically ill adults. Here the influence on inflammatory processes, immune function and clinical endpoints is not clear, since there are too few studies and those that are available report contradictory findings. Fish oil is included in combination with other nutrients in various enteral formulas. In post-surgical patients and in those with mild sepsis or trauma, there is clinical benefit from a formula including fish oil and arginine. A formula including fish oil, borage oil and antioxidants has demonstrated marked benefits on gas exchange, ventilation requirement, new organ failures, ICU stay and mortality in patients with acute respiratory distress syndrome, acute lung injury or severe sepsis.

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Effects of Intravenously Infused Fish Oil on Platelet Fatty Acid Phospholipid Composition and on Platelet Function in Postoperative Trauma

Abstract: A short-term IV infusion of fish oil clearly modifies the platelet composition and changes some parameters of platelet function.

Cited by 60 publications

References 30 publications

Impact of postoperative omega-3 fatty acid-supplemented parenteral nutrition on clinical outcomes and immunomodulations in colorectal cancer patients

Impact of postoperative omega-3 fatty acid-supplemented parenteral nutrition on clinical outcomes and immunomodulations in colorectal cancer patients

Long-chain n-3 fatty acids and inflammation: potential application in surgical and trauma patients

Rationale and use of n-3 fatty acids in artificial nutrition

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