Effects of Intravenous Versus Epidural Lidocaine Infusion on Pain Intensity and Bowel Function After Major Large Bowel Surgery: a Double-Blind Randomized Controlled Trial

Abstract

Compared with LEA-lidocaine or placebo, intravenous lidocaine offered no clinically significant benefit in terms of analgesia and bowel function.

Intravenous lignocaine in colorectal surgery: a systematic review

“…Opioid consumption and pain scores for trials comparing IVL with epidural analgesia are shown in Table . Two studies showed no significant difference between the two groups. The other studies showed a decrease in opioid consumption and pain scores in the epidural group compared with IVL; however, no P ‐values were given.…”

Effects of perioperative intravenous lidocaine infusion for postoperative pain and recovery in elderly patients undergoing surgery: a systematic review and meta-analysis of randomized controlled trials

“…Postoperative pain was evaluated by different pain scores. The pain scores were provided in totally 11 studies of 18 RCTs which had sufficient quantitative data to be combined through meta-analysis [19][20][21][22][23][24][25][26][27][28][29] .Five studies assessed postoperative pain on a visual analogue scale (VAS) from 0 to 100mm and five studies used the VAS from 0 to 10cm measurement, while one trial evaluated postoperative pain with NRS.…”

“…As shown in Fig. 4, postoperative pain scores at rest were evaluated in 10 studies [19][20][21][22][23][24][25][26][27][28] .Meta-analysis of pain data at rest was statistically significant decrease VAS scores in lidocaine group compared with the control group at 2h (7 studies, n=386, SMD -1.30 95%CI -1.90 to -0.70), at 4h (7 studies, n=364, SMD -1.20 95%CI -1.91 to -0.49), at 6h (3 studies, n=208, SMD -0.87 95%CI -1.72 to -0.02), at 8h (5 studies, n=284, SMD -0.84 95%CI -1.40 to -0.27), at 12h (4 studies, n=267, SMD -0.73 95%CI -1.14 to -0.32), at 18h (3 studies, n=208, SMD -0.79 95%CI -1.78 to 0.20), at 24h (10 studies, n=569, SMD -0.39 95%CI -0.66 to -0.11), at 48h (8 studies, n=458, SMD -0.25 95%CI -0.59 to 0.10). The outcome adequately revealed that perioperative intravenous lidocaine infusion can reduced postoperative pain scores in elderly patients of abdominal, cardiac, orthopedic, urinary, endoscopic surgery at 2h, 4h, 6h,8h, 12h, 24h after surgery, but did not decreased the pain scores at 18h and 48h after surgery.…”

“…Morphine was applied for postoperative pain relief in 6 trials [20,23,25,27,30,33] , 4 trials [19,21,26,28] applied fentanyl, one trial [29] offered meperidine. Pooled meta-analysis revealed the lidocaine group had fewer opioid requirements (MEQ, mg) after surgery in comparison to the control group (SMD -0.31 95%CI -0.61 to -0.01).…”

“…Six studies [20,25,29,30,33,35] with 285 patients reported data on the time to first flatus and the time to first defaecation/bowel movement.…”