Effects of Intravenous Verapamil on Hemodynamics and Pulmonary Gas Exchanges in Isoflurane-N2O-O2 Anesthetized Man

Kim, Ki Sun; Yoo, Kyung Yeun; Im, Woong Mo; Ha, In Ho

doi:10.4097/kjae.1989.22.2.315

Cited by 1 publication

(2 citation statements)

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“…Using Cu(OTf) 2 as catalyst, the silyl or stannyl functionalities served as leaving groups in the oxidation of CH 2 CH 2 CH 2 TMS to CH 2 CH 2 CH 2 NHTs with PhINTs (Scheme 14). 55 One suggested mechanism involved initial formation of the aziridine followed by desilylation or destannylation.…”

Section: The Earliest Example Of Metal-catalyzed C−h Bond Amination D...mentioning

confidence: 99%

“…While strictly not C–H amination, the use of a C–SiMe 3 proxy for the C–H group in an allylic position allowed for the formation of allylamines with Cu(OTf) 2 and PhINTs. Using Cu(OTf) 2 as catalyst, the silyl or stannyl functionalities served as leaving groups in the oxidation of CH 2 CH 2 CH 2 TMS to CH 2 CH 2 CH 2 NHTs with PhINTs (Scheme ) . One suggested mechanism involved initial formation of the aziridine followed by desilylation or destannylation.…”

Section: Development Of C–h Amination Catalysts From Alkene Aziridina...mentioning

confidence: 99%

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Copper-Catalyzed sp³ C–H Amination

2012

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Among the transition metals, copper-based catalyst systems enable the widest range of N-containing reagents in C−H amination to allow for the direct incorporation of versatile N-based functionalities via ubiquitous C−H bonds. In addition to nitrene-based approaches involving sulfonyliminoiodinanes (PhINSO 2 R), diverse non-nitrene protocols have been developed that allow for the direct use of organic amides, nitrosoarenes, and hydroxylamines, strained heterocycles such as oxaziridines, acetonitrile, secondary sulfonylamines, and even alkylamines and arylamines. Synthetic, mechanistic, and theoretical studies reveal discrete copper nitrenes [Cu]NR and copper amides [Cu]−NHR to be key reactive intermediates in C−H amination. Copper-catalyzed sp 3 C−H amination is reviewed, connecting catalytic reactivity patterns with likely copper intermediates wherever possible, with the goal to stimulate the further development of C−H functionalization reactions with copper which possess significant sustainability advantages over other contemporary approaches involving noble metals.

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Section: The Earliest Example Of Metal-catalyzed C−h Bond Amination D...mentioning

confidence: 99%

Section: Development Of C–h Amination Catalysts From Alkene Aziridina...mentioning

confidence: 99%