Effects of intravenous infusion of highly purified vitamin B 2 on lipopolysaccharide-induced shock and bacterial infection in mice

Toyosawa, Toshio; Suzuki, Mamoru; Kodama, Kazuhisa; Araki, Seiichi

doi:10.1016/j.ejphar.2004.04.004

Cited by 47 publications

(25 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In addition, RF decreased the elevation of TNF-α, IL-1β, MPC-1, IL-6, and NO level in plasma. [8] LPS-induced shock model in mice RF at 2.5 or 10 mg/kg for 6 h continuous i.v bolus administration with or without aminolevane ® or single dose injection with or without amino acids or valine after 6 h LPS injection.…”

Section: Immune Systemmentioning

confidence: 99%

“…The beneficial effects of RF are based on its anti-inflammatory capability. Several experimental animal models have shown that RF has a potent effect against mortality rates from LPS-induced septic shock, exotoxin and exotoxin-induced shock, Gram-positive and Gram-negative bacterial infections via reduction the elevated level of TNF-α, IL-1, IL-1β, IL-6, gamma interferon (IFN-γ), MCP-1, and 2 MIP-2 as well as NO levels [8,42,43].…”

Section: Immune Systemmentioning

confidence: 99%

“…Both FMN and FAD play a key role as cofactors in energy metabolism and are required for co-enzyme function in numerous oxidation and reduction reactions in all aerobic forms of life. RF has been used in dietary supplements and for inflammatory disease treatments such as angulus infectious, cheilitis, glossitis [7], sepsis [8,9], cataracts and migraine headaches [3] (Figure 2). Table 1.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Riboflavin: The Health Benefits of a Forgotten Natural Vitamin

Suwannasom

Kao

Pruß

et al. 2020

IJMS

232

107

View full text Add to dashboard Cite

Riboflavin (RF) is a water-soluble member of the B-vitamin family. Sufficient dietary and supplemental RF intake appears to have a protective effect on various medical conditions such as sepsis, ischemia etc., while it also contributes to the reduction in the risk of some forms of cancer in humans. These biological effects of RF have been widely studied for their anti-oxidant, anti-aging, anti-inflammatory, anti-nociceptive and anti-cancer properties. Moreover, the combination of RF and other compounds or drugs can have a wide variety of effects and protective properties, and diminish the toxic effect of drugs in several treatments. Research has been done in order to review the latest findings about the link between RF and different clinical aberrations. Since further studies have been published in this field, it is appropriate to consider a re-evaluation of the importance of RF in terms of its beneficial properties.

show abstract

Section: Immune Systemmentioning

confidence: 99%

Section: Immune Systemmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Riboflavin: The Health Benefits of a Forgotten Natural Vitamin

Suwannasom

Kao

Pruß

et al. 2020

IJMS

232

107

View full text Add to dashboard Cite

show abstract

“…Riboflavin as a proteasome inhibitor quenches inflammation by reduction of proinflammatory cytokines [10]. Moreover, in-vivo treatment of mice with Riboflavin reduces the mortality of mice with septic shock [11] and enhances the resistance to bacterial infections [12]. …”

Section: Introductionmentioning

confidence: 99%

Riboflavin along with antibiotics balances reactive oxygen species and inflammatory cytokines and controls Staphylococcus aureus infection by boosting murine macrophage function and regulates inflammation

Dey

Bishayi

2016

J Inflamm

View full text Add to dashboard Cite

BackgroundMacrophages serve as intracellular reservoirs of S. aureus. Recent in vitro studies have confirmed high level resistance by S. aureus to macrophage mediated killing and the intracellular persistence of Staphylococci may play an important role in the pathogenesis. Since this localization protects them from both cell-mediated and humoral immune responses, therefore, a successful anti-staphylococcal therapy should include the elimination of intracellular bacteria, further protecting the host cells from staphylococci-induced cell death. So, only antibiotic therapy may not be helpful, successful therapy needs combination of drugs not only for elimination of pathogen but also for rescuing the host cell for S. aureus induced cell death.MethodsIn keeping with this idea an in vitro study has been done to examine the effect of Riboflavin along with antibiotics on phagocytosis, hydorgen peroxide, superoxide production, antioxidant enzyme levels, and cytokine levels in mouse macrophages for amelioration of the Staphylococcus aureus burden. The immune boosting effects of Riboflavin have been validated through perturbations of redox homeostasis and pro-inflammatory cytokines measurements.ResultsIt was observed that the supplementation of Vitamin B-2 (Riboflavin) not only enhances macrophage function as previously reported but also decreases pro-inflammatory responses in Staphylococcus aureus infected macrophages. The observed influence of Riboflavin on enhanced antimicrobial effects such as enhanced phagocytosis of macrophages exposed to S. aureus, hydrogen peroxide or superoxide production when combined with either ciprofloxacin (CIP) or Azithromycin (AZM) and decrease in pro-inflammatory responses of IFN-γ, IL-6, IL-1β. Riboflavin treatment also decreased NO and TNF-α level possibly by inhibiting the NF-κβ pathway. The increased antioxidant enzymes like glutathione reductase, SOD and GSH level helped in maintaining a stable redox state in the cell.ConclusionRiboflavin plus antibiotic pretreatment not only enhances macrophage functions but also decreases proinflammatory responses in Staphylococcus aureus infected macrophages indicating better bacterial clearance and regulated inflammation which may be considered as a novel and important therapeutic intervention.

show abstract

“…87,88 An intravenous infusion of B 2 also significantly improved LPS-induced endotoxin shock and significantly reduced the lethality of E. coli infections. 89 The reduction of elevated pro-inflammatory cytokines and nitric oxide may be the mechanism underlying the antiseptic effects of B 2 . 90…”

Section: Vitamin Bmentioning

confidence: 99%

The Comparative Impact of Iron, the B-Complex Vitamins, Vitamins C and E, and Selenium on Diarrheal Pathogen Outcomes Relative to the Impact Produced by Vitamin A and Zinc

Long¹,

Rosado

Fawzi

2008

Nutrition Reviews

View full text Add to dashboard Cite

Micronutrient supplementation offers one of the most cost-effective means of improving the health and survival of children in developing countries. However, the effects of supplementation with single micronutrients on diarrhea are not always consistent, and supplementation with multi-micronutrient supplements can have negative effects. These inconsistencies may result from the failure to consider the diverse etiological agents that cause diarrhea and the unique effects each micronutrient has on the immune response to each of these agents. This review examines the separate effects that supplementation with the B-complex vitamins, vitamin C, vitamin E, selenium, and iron have on diarrheal disease-related outcomes. Supplementation with iron may increase the risk of infection by invasive diarrheal pathogens, while supplementation with the remaining micronutrients may reduce this risk. These differences may be due to distinct regulatory effects each micronutrient has on the pathogen-specific immune response, as well as on the virulence of specific pathogens. The findings of these studies suggest that micronutrient supplementation of children must take into account the pathogens prevalent within communities as reflected by their diarrheal disease burdens. The effectiveness of combining multiple micronutrients into one supplement must also be reconsidered.

show abstract

Effects of intravenous infusion of highly purified vitamin B 2 on lipopolysaccharide-induced shock and bacterial infection in mice

Cited by 47 publications

References 19 publications

Riboflavin: The Health Benefits of a Forgotten Natural Vitamin

Riboflavin: The Health Benefits of a Forgotten Natural Vitamin

Riboflavin along with antibiotics balances reactive oxygen species and inflammatory cytokines and controls Staphylococcus aureus infection by boosting murine macrophage function and regulates inflammation

The Comparative Impact of Iron, the B-Complex Vitamins, Vitamins C and E, and Selenium on Diarrheal Pathogen Outcomes Relative to the Impact Produced by Vitamin A and Zinc

Contact Info

Product

Resources

About