Effects of Intravenous Epinine Administration on Left Ventricular Systolic Performance, Coronary Hemodynamics, and Circulating Catecholamines in Patients with Heart Failure

Rousseau, Michel F.; Raigoso, J.; Eyll, Christian van; Mechelen, Henri Van; Musso, Natale R.; Lotti, G; Pouleur, H.

doi:10.1097/00005344-199202000-00001

Cited by 25 publications

(9 citation statements)

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“…4 The active metabolite stimulates DA-1 and DA-2 receptors and causes renal and peripheral vasodilatation, and does not seem to have an inotropic effect. 5 Previous studies showed that in patients with heart failure, ibopamine reduced plasma concentrations of noradrenaline, renin activity, and aldosterone. [6][7][8] Clinical studies have reported that ibopamine improves symptoms and has an effect similar to captopril on exercise tolerance in patients with mild-tomoderate heart failure.…”

Section: Introductionmentioning

confidence: 99%

Randomised study of effect of ibopamine on survival in patients with advanced severe heart failure

et al. 1997

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Randomised study of effect of ibopamine on survival in patients with advanced severe heart failure Hampton, J.R.; Veldhuisen, D.J.; Kleber, F.X.; Cowley, A.J.; Ardia, A.; Block, P.; Cortina, A.; Cserhalmi, L.; Follath, F.; Jensen, G.; Kayanakis, J.; Lie, K.I.; Mancia, G.; Skene, A.M. Published in: Lancet DOI:10.1016/S0140-6736(96)10488-8 Link to publicationCitation for published version (APA): Hampton, J. R., Veldhuisen, D. J., Kleber, F. X., Cowley, A. J., Ardia, A., Block, P., ... Skene, A. M. (1997). Randomised study of effect of ibopamine on survival in patients with advanced severe heart failure. Lancet, 349, 971-977. https://doi.org/10.1016/S0140-6736(96)10488-8 General rightsIt is not permitted to download or to forward/distribute the text or part of it without the consent of the author(s) and/or copyright holder(s), other than for strictly personal, individual use, unless the work is under an open content license (like Creative Commons). Disclaimer/Complaints regulationsIf you believe that digital publication of certain material infringes any of your rights or (privacy) interests, please let the Library know, stating your reasons. In case of a legitimate complaint, the Library will make the material inaccessible and/or remove it from the website. Please Ask the Library: http://uba.uva.nl/en/contact, or a letter to: Library of the University of Amsterdam, Secretariat, Singel 425, 1012 WP Amsterdam, The Netherlands. You will be contacted as soon as possible. Download date: 22 Mar 2019Randomised study of effect of ibopamine on survival in patients with advanced severe heart failure J R Hampton, D J van Veldhuisen, F X Kleber, A J Cowley, A Ardia, P Block, A Cortina, L Cserhalmi, F Follath, G Jensen, J Kayanakis, K I Lie, G Mancia, A M Skene, for the Second Prospective Randomised Study of Ibopamine on Mortality and Efficacy (PRIME II) Investigators THE LANCET SummaryBackground Drugs that improve symptoms in patients with heart failure must also be assessed for their effects on survival. Ibopamine stimulates DA-1 and DA-2 receptors and causes peripheral and renal vasodilatation; the drug improves symptoms of heart failure. W e assessed the effect of ibopamine on survival in patients with advanced heart failure in a mult ic ent re, randomised plac ebocontrolled study.

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Section: Introductionmentioning

confidence: 99%

Randomised study of effect of ibopamine on survival in patients with advanced severe heart failure

et al. 1997

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“…In the presence of the c~-receptor antagonist phentolamine, a relaxant effect of epinine was observed which could be antagonized by the specific D~-receptor antagonist SCH 23390. In contrast to some in vivo studies (Taylor and Cicchetti 1990;Rousseau et al 1992), the precontracted isolated human renal artery rings relaxed only after incubation with the e-adrenoceptor antagonist phentolamine. Also Itoh and colleges (1985) conducted from experiments in dog that a consistent increase in renal blood flow was prevented because the D1 activity of epinine was offset by the ~-adrenergic activity.…”

Section: Discussionmentioning

confidence: 60%

“…This is in agreement with the in vivo situation. The free plasma concentrations of epinine in vivo have been reported to be similar as the concentration of epinine which produced vasodilatory activity (Rousseau et al 1992). Intravenous administration of epinine at concentrations comparable to those reached after p.o.…”

Section: Discussionmentioning

confidence: 89%

“…Epinine and dopamine is suggested to be taken up in catecholamine stores displacing endogenous catecholamines which in turn mediate part of the observed adrenergic effects (Port et al 1990;Rousseau et al 1992;Nichols and Ruffolo 1987). This indirect effect is dependent on the stored amount of catecholamines and may differ in failing and nonfailing human tissue.…”

Section: Discussionmentioning

confidence: 99%

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Effect of epinine on tension of human renal arteries

Schwinger

Schulz

Brixius

et al. 1996

Naunyn-Schmiedeberg's Arch Pharmacol

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“…Furthermore, we have shown previously that DI-receptors do not play a major role in the heart, under physiological conditions (Van Woerkens et al, 1991). The lack of a pronounced positive inotropic action of epinine was recently confirmed by infusion of epinine in patients with moderate heart failure due to ischaemic heart disease (Rousseau et al, 1992).…”

Section: Discussionmentioning

confidence: 86%

Differential cardiovascular and neuroendocrine effects of epinine and dopamine in conscious pigs before and after adrenoceptor blockade

Woerkens

Boomsma

Veld

et al. 1992

British J Pharmacology

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1 The effects of epinine or dopamine (both 1-10 tg kg-min-') on systemic haemodynamics and plasma concentrations of catecholamines and prolactin were studied in conscious pigs before and after combined non-selective a-and P-adrenoceptor blockade.2 The plasma concentrations of the two compounds did not differ from each other over the entire dose-range. 3 Epinine increased aortic blood flow (AoBF, 24 ± 6%), which was due to an increase in heart rate (HR) for doses less than 10 ,g kg-' min-'. At 10 fg kg-' min-', HR decreased slightly (10 ± 3%, as compared to the value obtained at 5 psg kg-' min-') and stroke volume increased up to 15% (P <0.05). Mean arterial pressure (MAP, 99 ± 3 mmHg at baseline) decreased dose-dependently (14 ± 2%, P <0.05) up to the infusion rate of 5 tLg kg-' min-, but increased by 4.0 ± 1.8 mmHg during infusion of 10 1tg kg' min-'. Systemic vascular resistance (SVR) decreased up to 23 ± 3% for doses less than 10 yg kg-I min', but did not change further during infusion of the highest dose. LVdP/dt,,,, increased during the two highest infusion rates up to 22 ± 6% (P <0.05). After the infusion was stopped there was an abrupt increase in HR (18 ± 4%, P<0.05) and a further decrease in SVR before all parameters returned to baseline. 4 Dopamine caused increases in AoBF (27 ± 3%) similar to epinine, the only difference being that HR continued to increase (32 ± 5%) and MAP (13 ± 3%) and SVR continued to decrease (31 ± 3%) over the entire dose-range. The increase in LVdP/dt,,,, at the highest dose (48 ± 4%, P <0.05) was more pronounced than with epinine. 5 Adrenoceptor blockade inhibited all epinine-induced changes, but did not affect the dopamineinduced changes in AoBF, SVR and MAP, but attenuated the increases in HR and LVdP/dtmax. 6 Noradrenaline (NA) and adrenaline (Ad) concentrations did not change during infusion of epinine or dopamine, but NA increased by 50% within 2.5 min after stopping the infusion of epinine. After adrenoceptor blockade NA and Ad concentrations did not change during infusion of dopamine, which contrasted with a decrease of 55 ± 5% (P<0.05) in NA during infusion of epinine. 7 Prolactin concentrations decreased gradually from 480 ± 40 pg ml-' to 270 ± 50 pg ml1' (P < 0.05) during infusion of epinine, but did not change significantly during dopamine infusion. 8 The differential effects of epinine and dopamine on MAP, SVR, plasma NA (before and after adrenoceptor blockade) and prolactin, leads us to conclude that in conscious pigs, epinine is a more potent a, P2 and D2-receptor agonist, but a weaker D,-receptor agonist than dopamine.

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Effects of Intravenous Epinine Administration on Left Ventricular Systolic Performance, Coronary Hemodynamics, and Circulating Catecholamines in Patients with Heart Failure

Cited by 25 publications

References 0 publications

Randomised study of effect of ibopamine on survival in patients with advanced severe heart failure

Randomised study of effect of ibopamine on survival in patients with advanced severe heart failure

Effect of epinine on tension of human renal arteries

Differential cardiovascular and neuroendocrine effects of epinine and dopamine in conscious pigs before and after adrenoceptor blockade

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