Effects of intravenous alcohol on pancreatic and biliary secretion in man

Abstract

Two groups of men, nonalcoholics (mean daily alcohol consumption less than 40 g) and alcoholics (mean daily alcohol consumption greater than 100 g) were compared with respect to the effects of intravenous ethanol on hormonally (secretin + CCK) submaximally stimulated pancreatic and bile secretion and chymotrypsin secretion during the basal state and after a Lundh test meal. Intravenous ethanol injection (600 mg/kg) significantly decreased pancreatic secretion of lipase (-74%), chymotrypsin (-78%), volume (-53%), and bicarbonate (-58%) in nonalcoholic but not in alcoholic men: The secretory pattern of the exocrine pancreatic response to an intravenous infusion of ethanol was therefore changes by the regular consumption of ethanol. The chymotrypsin concentration during the basal state was higher in alcoholic than in nonalcoholic men. This difference progressively disappeared after a test meal showing that chronic alcohol consumption modifies more basal than meal-stimulated pancreatic secretion.

Duodenal diazepam‐binding protein expression and plasma cholecystokinin after alcoholic pancreatitis

“…After an intravenous ethanol injection (600 mg/kg), pancreatic secretion of lipase, chymotrypsin volume and bicarbonate was significantly decreased in non-alcoholic men but not in alcoholics [19]. CCK is thought to mediate the alcohol-induced increase in pancreatic secretion [13][14][15].…”

Cholinergic Hypothesis of Alcoholic Pancreatitis

“…Acute intravenous injection of ethanol decreased pancreatic se cretion in control dogs, but a paradoxal stim-illation of pancreatic secretion was produced after chronic alcohol exposure. This phenom enon was also demonstrated in man [20,21]. Tiscornia ct al.…”

Alcohol and the Pancreas

“…Therefore as long as comparative experiments are ethically possible in man, it seems that the human pancreatic secretory response of protein to alcohol is not very different from the dog response. Inhibition disappears in chronic alcoholic men as well as in chronic alcoholic dogs (63).…”