Effects of intrathecal bupivacaine–fentanyl versus bupivacaine–dexmedetomidine in diabetic surgical patients

Tarbeeh, Gehan A.; Mohamed, Ayman A.

doi:10.1016/j.egja.2012.08.008

Cited by 13 publications

(16 citation statements)

References 14 publications

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“…15 Tarbeehet et al and Jamlia RH et al also found that dexmedetomidine has a dose dependent effect on onset and regression of motor and sensory block and time to rescue analgesia with lower VAS scores and minimal side effects when used as an adjuvant to intrathecal bupivacaine. Similar results were found by halder et al 16,17,18 In our study the onset of sensory block was earlier in dexmedetomidine group with much earlier in group D10. Ogan et al showed an earlier significant peak sensory block in dexmedetomidine group compared to other groups.…”

Section: Discussionsupporting

confidence: 82%

Comparative Evaluation of Intrathecal Use of two Different Doses of Dexmedetomidine Along with Bupivacaine in Lower Abdominal Surgeries

Bansal¹,

Khatri²

2016

IOSR

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Abstract:Introduction: group B 11.6±1.12, group D5 5.84±2.02, group D10-4.92±1.23 (p <0.001). Total duration of sensory block was (in minutes) group B 172.61±24.68, group D5 268.34±28.42, group D10 346.28±44.8 (p <0.001). Total duration of motor block (in minutes) group B 150.66±18.64, group D5 268.44±24.85, group D10 322.9±49.68 (p <0.001). Duration of analgesia (in minutes) -group B 124.01±8.552, group D5 194.68±18.44, group D10 290.48±20.64 (p <0.001). Conclusion: dexmedetomidine added to hyperbaric bupivacaine intrathecally has a dose dependent favourable effect on the onset and regression of motor and sensory block.

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Section: Discussionsupporting

confidence: 82%

Comparative Evaluation of Intrathecal Use of two Different Doses of Dexmedetomidine Along with Bupivacaine in Lower Abdominal Surgeries

Bansal¹,

Khatri²

2016

IOSR

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“…In our study, maximum level of sensory blockade was not significant statistically. Our results were comparable with Mahendru V et al 3 , Al-Ghanem SM et al 5 , Gupta R et al 6 , Tarbeeh GA et al 9 They have also not found statistically significant difference between dexmedetomidine and fentanyl group. In our study, mean time taken for the sensory regression by two segments 95.8±21.3, 130±17.238, 131±22.748 min in group C, group D, group F respectively.…”

Section: Demographic Datasupporting

confidence: 82%

“…In our study, mean duration of motor blockade was prolonged in Group-D and statistically significant compared with Group-F. Our study compares with studies conducted by Al-Ghanem SM et al 5 , Gupta R et al 6 , Mahendru V et al 3 and Tarbeeh GA et al 9 , who also have found statistically significant difference when Dexmedetomidine group was compared with Fentanyl group.…”

Section: Demographic Datasupporting

confidence: 63%

“…Statistically, there was significant increase in mean duration of motor blockade in Group-D and Group-F as compared to Group-C. Statistically, there was significant increase in mean duration of motor blockade in Group-D as compared to Group-F. Our study compares with the study conducted by Tarbeeh GA et al 9 , who also found statistically significant difference in mean time taken for duration of motor blockade between Dexmedetomidine group and Fentanyl group compared with Bupivacaine group.…”

Section: Demographic Datacontrasting

confidence: 46%

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A COMPARATIVE CLINICAL STUDY OF INTRATHECAL DEXMEDETOMIDINE 5 µg AND INTRATHECAL FENTANYL 25 µg AS AN ADJUVANT WITH 0.5% HYPERBARIC BUPIVACAINE 12.5 mg IN ELECTIVE LOWER LIMB SURGERIES

Shashikala¹,

Sanjeev²,

Prathibha³

et al. 2016

jemds

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“…Similar observation was made by Mohammed et al 12 . It may be due to sympatholytic effect of dexmedetomidine.Gupta et al 6 , Al-Mustafa et al 9 and Tarbeeh et al 13 did not find much change between the groups.…”

Section: Figuresupporting

confidence: 77%

A comparative study of intrathecal 0.5% hyperbaric bupivacaine with dexmedetomidine and 0.5% hyperbaric bupivacaine with fentanyl for lower abdominal surgeries

Govindswamy

Curpod

2016

Sri Lankan J Anaesthesiol

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BackgroundAdjuvants are added to improve the quality, to accelerate the onset of action and to overcome the problems of spinal anaesthesia. Depending on the purpose various adjuvants like morphine, fentanyl, clonidine, midazolam and dexmedetomidine are added. Adjuvants are administered by various routes like epidural, intrathecal and intravenous. Materials and methodsFollowing detailed pre-anesthetic check-up, patients were randomised into 2 groups in a sealed envelope, Group D received 2.5ml of 0.5% hyperbaric bupivacaine with 5µg dexmedetomidine and Group F received 2.5ml of 0.5% hyperbaric bupivacaine with 25µg fentanyl. Subarachnoid block was given between L 3 -L 4 space with 25G Quincke spinal needle under aseptic precautions after free and clear flow of CSF in sitting posture. Onset of action, level of blockade, sedation score, duration of analgesia, adverse effects and hemodynamics were monitored. The first rescue analgesia was given when Visual Analogue Scale (VAS) was >4. ResultsIn our study dexmedetomidine provided better sensory block, motor block and longer duration of analgesia. The highest sensory level achievedby group D 6(4 -8) and in group F was 8(6-10)(p <0.005), time of two segment regression in group D110.33 ± 11.544min and group F 81.50±15.6 min (p <0.001), time of regression to S 1 segment group D453.67±23.265 and group F 180.70± 18.235 (p<0.001), motor blockade was in group D 407.53± 18.913 and in group F 149.37± 12.497 (p<0.001) and time to rescue analgesia group D 231.93± 17.836 and group F 160.13± 15.518min (p<0.001). The haemodynamic stability, sedation and side effects were similar in both the groups (p>0.05). ConclusionWe conclude that dexmedetomidine may be used as an alternate to fentanyl for intrathecal use and it may find a place forregular use in clinical practice.

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Effects of intrathecal bupivacaine–fentanyl versus bupivacaine–dexmedetomidine in diabetic surgical patients

Cited by 13 publications

References 14 publications

Comparative Evaluation of Intrathecal Use of two Different Doses of Dexmedetomidine Along with Bupivacaine in Lower Abdominal Surgeries

Comparative Evaluation of Intrathecal Use of two Different Doses of Dexmedetomidine Along with Bupivacaine in Lower Abdominal Surgeries

A COMPARATIVE CLINICAL STUDY OF INTRATHECAL DEXMEDETOMIDINE 5 µg AND INTRATHECAL FENTANYL 25 µg AS AN ADJUVANT WITH 0.5% HYPERBARIC BUPIVACAINE 12.5 mg IN ELECTIVE LOWER LIMB SURGERIES

A comparative study of intrathecal 0.5% hyperbaric bupivacaine with dexmedetomidine and 0.5% hyperbaric bupivacaine with fentanyl for lower abdominal surgeries

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