Effects of intrathecal and i.c.v. administration of neuropeptide W-23 and neuropeptide B on the mechanical allodynia induced by partial sciatic nerve ligation in rats

Yamamoto, Tatsuo; Saito, Osamu; Shono, Koyo; Tanabe, Serabi

doi:10.1016/j.neuroscience.2005.08.066

Cited by 13 publications

(10 citation statements)

References 24 publications

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“…In agreement with results obtained in rats, these NPB knockout mice did not demonstrate hyperalgesia to chemical or thermal pain (Kelly et al ., 2005). Therefore, activation of NPBW 1 at the spinal level has been shown to produce an analgesic and anti‐allodynia effect in response to acute inflammatory pain (Yamamoto et al ., 2005, 2006), consistent with the reported effect of upregulation of NPBW 1 in nerves of the peripheral nervous system during the pathogenesis of inflammatory neuropathies (Zaratin et al ., 2005).…”

Section: Physiological Role Of Npbw1supporting

confidence: 88%

Neuropeptide B and W: neurotransmitters in an emerging G‐protein‐coupled receptor system

Singh

Davenport

2006

British J Pharmacology

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Deorphanised G-protein-coupled receptors represent new and expanding targets for drug development. Neuropeptide B (NPB) and W (NPW) have recently been identified as the cognate endogenous ligands for the orphan receptor GPR7, now designated as NPBW 1 . NPB and NPW also bound to a second related orphan receptor, GPR8, now designated as NPBW 2 that is present in humans but not rats or mice. In humans, high levels of NPW mRNA have been visualised in the substantia nigra, whereas moderate expression levels have been detected in the amygdala and hippocampus. In peripheral tissues, expression of NPW mRNA has been confirmed in the progenital system, comprising the kidney, testis, uterus, ovary and placenta, and also in stomach homogenates. Immunocytochemical, molecular biological and autoradiography techniques have revealed a discrete CNS distribution for NPBW 1 in human, mouse and rat. Highest expression of NPBW 1 mRNA and protein was identified in the amygdala and hypothalamic nuclei known to regulate feeding behaviour. protein. Physiological studies demonstrate that intracerebroventricular infusion of NPBW 1 ligands modulates feeding behaviour, regulates the release of corticosterone, prolactin and growth hormone while also manipulating pain pathway. Mouse knockout models of the gene encoding either NPB or NPBW 1 have a gender-specific phenotype, with moderate obesity evident in males but not females. Further investigation is required to elucidate the precise physiological role of NPB and NPW as neurotransmitters.

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Section: Physiological Role Of Npbw1supporting

confidence: 88%

Neuropeptide B and W: neurotransmitters in an emerging G‐protein‐coupled receptor system

Singh

Davenport

2006

British J Pharmacology

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“…Intrathecal administration of either NPB or NPW23 diminished mechanical allodynia via activation of NPBWR1 receptors; nevertheless, the level of thermal hyperalgesia remains stable. These effects were not inhibited by the naloxone, an opioid receptor antagonist, which indicate involvement of an independent analgesic pathway compared to the opioid peptides ( Yamamoto et al, 2005 , 2006 ) in which myelin-forming Schwann cells could be involved, while they express low level of NPBWR1 under physiological conditions and in much higher amount in patients with inflammatory neuropathies ( Zaratin et al, 2005 ). Thus, NPB/W signaling can play a role in modulation of nociceptive transmission in peripheral nerves.…”

Section: Physiological Effectsmentioning

confidence: 93%

“…Additionally, many NPW-IR nerve fibers were in direct contact with melanin-concentrating hormone-containing neurons and orexin-containing neurons in the lateral hypothalamic area ( Takenoya et al, 2008 ). In the dorsal root ganglion, some NPW-IR neurons contained also calcitonin gene-related peptide or isolectin B4 ( Yamamoto et al, 2006 ). In the rat medulla, NPW was co-localized with noradrenaline but not with adrenaline ( Seki et al, 2008 ).…”

Section: Distributionmentioning

confidence: 99%

Distribution and Function of Neuropeptides W/B Signaling System

Dvoráková

2018

Front. Physiol.

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Neuropeptide W (NPW) and neuropeptide B (NPB) are two structurally and functionally related regulatory peptides, which are highly expressed in several brain regions and, additionally, in some peripheral tissues. Nevertheless, their distributions in the tissues are not similar. They act on target tissues via two subtypes of G protein-coupled receptors which are designated as NPBWR1 (GPR7) and NPBWR2 (GPR8), respectively, and possess different binding affinities. NPB activates NPBWR1, whereas NPW stimulates both the receptors with similar potency. Both of these peptides takes a part in the central regulation of neuroendocrine axes, feeding behavior, energy homeostasis, cardiovascular functions, circadian rhythm, pain sensation, modulation of inflammatory pain, and emotions. Over the past few years, studies have shown that NPB is also involved in sleep regulation. On the contrary, NPW participates in regulation of vascular myogenic tone, inhibits gastric tension sensitive vagal afferents and insulin secretion. Also, expression of NPW in the stomach is regulated by feeding. Abovementioned findings clearly demonstrate the functional diversity among NPW versus NPB signaling systems. In this review, signal transduction pathways of NPW/NPB are critically evaluated and observed together with mapping of expression of their signaling systems.

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“…Neuropeptide B, endogenous ligands of GPR7 reduced mechanical allodynia induced by sciatic nerve ligation in a naloxone-insensitive manner (1256). Intrathecal CART (55-102) attenuated hyperalgesia and allodynia in as mouse model of neuropathic, but not inflammatory pain in a naloxone-independent manner (259).…”

Section: D-ii Opioid-insensitive Analgesic Responses-intrathecal Bmentioning

confidence: 99%

Endogenous opiates and behavior: 2009

Bodnar

2010

Peptides

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Effects of intrathecal and i.c.v. administration of neuropeptide W-23 and neuropeptide B on the mechanical allodynia induced by partial sciatic nerve ligation in rats

Cited by 13 publications

References 24 publications

Neuropeptide B and W: neurotransmitters in an emerging G‐protein‐coupled receptor system

Neuropeptide B and W: neurotransmitters in an emerging G‐protein‐coupled receptor system

Distribution and Function of Neuropeptides W/B Signaling System

Endogenous opiates and behavior: 2009

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