Effects of intranasal oxytocin administration on memory for infant cues: Moderation by childhood emotional maltreatment

Bhandari, Ritu; Veen, Rixt van der; Parsons, Christine E.; Young, Katherine S.; Voorthuis, Alexandra; Bakermans‐Kranenburg, Marian J.; Stein, Alan; Kringelbach, Morten L.; IJzendoorn, M.H. van

doi:10.1080/17470919.2014.932307

Cited by 19 publications

(15 citation statements)

References 57 publications

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“…Their study showed that maltreatment affects emotional information processing, and that high OT levels were correlated with higher self‐reported emotional maltreatment. In the same context, the authors assessed the effects of OT on memory for infant cues. Participants were asked to select the happier infant from a pair of two infants, based on the information that they received about the infant's mood.…”

Section: Discussionmentioning

confidence: 99%

Psychophysiological effects of oxytocin on parent–child interactions: A literature review on oxytocin and parent–child interactions

Szymanska

Schneider

Chateau-Smith

et al. 2017

Psychiatry Clin Neurosci

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Oxytocin (OT), often called the 'hormone of love' or 'hormone of attachment,' plays a fundamental role in the establishment and quality of parent-infant bonding. However, emerging evidence indicates that OT can also produce antisocial behavior. To clarify these effects, we review studies examining the role of endogenous and exogenous OT on several determinants of attachment: parental sensitivity, and bonding or synchrony in parent-child dyads. Contextual and individual factors moderating the effect of intranasal OT and its peripheral levels are also reviewed. Finally, potential therapeutic applications for OT and current limitations in human OT research are examined. This systematic literature review was based on the Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) guidelines, with two electronic databases and other bibliographic sources. We identified a total of 47 relevant studies for inclusion in our review. Most of the findings are in accordance with recent ideas that OT administration may increase parent-child prosocial interaction, showing that OT exerts beneficial effects on processes thought to promote bonding, sensitivity, and synchrony. However, we found that OT can induce antisocial behavior (e.g., anxiety) or adverse effects (modulation of maternal care recollections) that are moderated by different contextual (e.g., maltreatment level, presence of unfamiliar people) and individual (attachment style) factors. This review reinforces the importance of context- and individual-dependent factors, which must be taken into account when analyzing the psychophysiological effects of OT.

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Section: Discussionmentioning

confidence: 99%

Psychophysiological effects of oxytocin on parent–child interactions: A literature review on oxytocin and parent–child interactions

Szymanska

Schneider

Chateau-Smith

et al. 2017

Psychiatry Clin Neurosci

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“…New learning paradigms derived from neuroscientific findings have already shown considerable promise [27, 79]. For example, the “baby-social-reward-task”, which uses cute sounds and faces, mimics important aspects of caregiving and has been able to shift perceptions of infant temperament [27, 85]. Musical training has also been implicated in sensitivity and empathy for infant distress [79, 86], in that specific training has improved caregiver sensitivity.…”

Section: Difficulties In Prioritising Attentional Resporces To Cute Smentioning

confidence: 99%

On Cuteness: Unlocking the Parental Brain and Beyond

Kringelbach

Stark

Alexander

et al. 2016

Trends in Cognitive Sciences

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181

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Cuteness in offspring is a potent protective mechanism that ensures survival for otherwise completely dependent infants. Previous research has linked cuteness to early ethological ideas of a “kindchenschema” (infant schema) where infant facial features serve as “innate releasing mechanisms” for instinctual caregiving behaviours. We propose extending the concept of cuteness beyond visual features to include positive infant sounds and smells. Evidence from behavioural and neuroimaging studies links this extended concept of cuteness to simple “instinctual” behaviours and to caregiving, protection and complex emotions. We review how cuteness supports key parental capacities by igniting fast privileged neural activity followed by slower processing in large brain networks also involved in play, empathy, and perhaps even higher-order moral emotions.

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“…For example, OT may promote sociality when administered in a safe environment, and defensiveness when administered in a conflictual setting 21 , 22 or to persons with an adverse early history. 23 , 24 …”

Section: Introductionmentioning

confidence: 99%

Long-term exposure to intranasal oxytocin in a mouse autism model

et al. 2014

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Oxytocin (OT) is a neuropeptide involved in mammalian social behavior. It is currently in clinical trials for the treatment of autism spectrum disorder (ASD). Previous studies in healthy rodents (prairie voles and C57BL/6J mice) have shown that there may be detrimental effects of long-term intranasal administration, raising the questions about safety and efficacy. To investigate the effects of OT on the aspects of ASD phenotype, we conducted the first study of chronic intranasal OT in a well-validated mouse model of autism, the BTBR T+ Itpr3tf/J inbred strain (BTBR), which displays low sociability and high repetitive behaviors. BTBR and C57BL/6J (B6) mice (N=94) were administered 0.8 IU/kg of OT intranasally, daily for 30 days, starting on day 21. We ran a well-characterized set of behavioral tasks relevant to diagnostic and associated symptoms of autism, including juvenile reciprocal social interactions, three-chambered social approach, open-field exploratory activity, repetitive self-grooming and fear-conditioned learning and memory, some during and some post treatment. Intranasal OT did not improve autism-relevant behaviors in BTBR, except for female sniffing in the three-chambered social interaction test. Male saline-treated BTBR mice showed increased interest in a novel mouse, both in chamber time and sniffing time, whereas OT-treated male BTBR mice showed a preference for the novel mouse in sniffing time only. No deleterious effects of OT were detected in either B6 or BTBR mice, except possibly for the lack of a preference for the novel mouse's chamber in OT-treated male BTBR mice. These results highlight the complexity inherent in understanding the effects of OT on behavior. Future investigations of chronic intranasal OT should include a wider dose range and early developmental time points in both healthy rodents and ASD models to affirm the efficacy and safety of OT.

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Effects of intranasal oxytocin administration on memory for infant cues: Moderation by childhood emotional maltreatment

Cited by 19 publications

References 57 publications

Psychophysiological effects of oxytocin on parent–child interactions: A literature review on oxytocin and parent–child interactions

Psychophysiological effects of oxytocin on parent–child interactions: A literature review on oxytocin and parent–child interactions

On Cuteness: Unlocking the Parental Brain and Beyond

Long-term exposure to intranasal oxytocin in a mouse autism model

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