Effects of Intranasal Azelastine on the Response to Nasal Allergen Challenge

Abstract

The effects of intranasal azelastine are similar to those of oral second-generation antihistamines.

A proof-of-concept study of the effect of a novel H3-receptor antagonist in allergen-induced nasal congestion

“…This is consistent with previous findings of increased levels of nasal proteins, namely ECP, IL-5, IL-13, and albumin, after allergen challenge. [27][28][29] The increase in levels of T H 2 cytokines and ECP in response to EEC ragweed exposure in nasal lavage specimens could be reduced by both JNJ-39220675 and pseudoephedrine. However, the accompanying reduction in albumin levels seen with both compounds suggests that this is due to vasoconstriction with an accompanying reduction in the size of the turbinates and is not an anti-inflammatory effect.…”

The correlation between allergic rhinitis and sleep disturbance

“…6,43 Topical antihistamines, delivered by means of nasal spray, avoid or minimize systemic side effects. Azelastine used topically reduced rhinorrhea but failed to reduce congestion in one study, 44 although not in another. 45 Thus the debate on the benefits of antihistamines on nasal congestion continues.…”

Allergic rhinitis-induced nasal congestion: its impact on sleep quality

“…42,53,54 Azelastine, an intranasal antihistamine with anti-inflammatory properties, has reduced nasal congestion and improved subjective sleep quality in small studies, but was also found to cause somnolence. 55,56 Decongestants are sympathomimetic drugs that constrict capacitance vessels in the turbinates and decrease nasal congestion. 46 Intranasal formulations act quickly, but their utility is limited by congestion rebound (rhinitis medicamentosa) that can occur after just a few days of regular use.…”