Effects of intralipid infusion on blood viscosity and other haemorheological parameters in neonates and children

Kessler, Ulf; Poeschl, Johannes; Raz, D; Linderkamp, Otwin; Bauer, John

doi:10.1111/j.1651-2227.2004.tb02718.x

Cited by 14 publications

(6 citation statements)

References 26 publications

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“…1). As we reported before, the decrease in RBC aggregation following in vitro incubation was strongly dependent on the IL concentration [25]. The in vitro addition of IL decreased plasma proteins by 1% (1 mg/ml) to 8% (8 mg/ml).…”

Section: Discussionsupporting

confidence: 72%

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Effects of Intralipid infusion on hemorheology and peripheral resistance in neonates and children

et al. 2005

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Deleterious microcirculatory effects of Intralipid (IL) infusion may be caused by hemorheological or vascular effects. The aim of this investigation was to study vascular and hemorheological effects of IL in preterm and fullterm neonates and children. Ten preterm newborns, 10 fullterm neonates, and 10 children received an initial infusion of IL (0.6 g/kg) over 4 h. Calf blood flow (venous occlusion plethysmography), blood pressure (Dinamap), whole blood and plasma viscosity (capillary viscometer), red blood cell deformability (rheoscope), and erythrocyte aggregation (aggregometer) were measured before and after administration of IL. Plasma triglyceride levels showed the greatest increase in preterm infants. Whole blood viscosity decreased by about 10% in all three groups because of a similar reduction in hematocrit. Red blood cell aggregation decreased by about 20% after IL infusion. Blood pressure rose by 10%, and peripheral blood flow declined by about 10% in the three groups. Vascular hindrance, a calculation of blood pressure divided by blood flow and viscosity, was raised by about 20%, suggesting marked vasoconstriction of peripheral arteries. Vasoconstriction rather than hemorheological changes during infusion of IL may play a crucial role in the pathogenesis of circulatory alterations in parenterallyfed neonates.

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Section: Discussionsupporting

confidence: 72%

“…Moreover, fatty acids may compete with the binding sites of macroproteins on the RBC surface [28]. Our finding of normalization of RBC aggregation after resuspending RBCs in IL-free plasma indicates that IL decreased RBC aggregation as a result of direct effects of IL compounds on RBCs [25].…”

Section: Discussionmentioning

confidence: 66%

Effects of Intralipid infusion on hemorheology and peripheral resistance in neonates and children

et al. 2005

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“…While LCT lack any effect on membrane surface marker expression in isolated neutrophils, we recently found a decreased expression of activation markers following lipid incubation of whole blood [18,19]. Infusion of LCT does not impair the flow properties of blood, suggesting that effects on plasma viscosity and cell deformability do not explain any effects of LCT [20].…”

Section: Long-chain Triglyceridesmentioning

confidence: 78%

An update on parenteral lipids and immune function: only smoke, or is there any fire?

Wanten

2006

Current Opinion in Clinical Nutrition &Amp; Metabolic Care

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“…12 In neonates, and particularly in premature infants with compromised lung function, a reduction in the amounts of potentially proinflammatory n-6 fatty acids from soybean oil may be indicated given their influence on pulmonary vasculature. 20 The use of other oils, such as olive oil, coconut-derived oil or fish oil in lipid emulsions, which have specific anti-inflammatory effects due to their elevated content of n-3 fatty acids, might offer additional clinical benefits. 9 Emulsions are inherently unstable dispersion systems, and even slight changes in their composition or storage conditions may result in droplet aggregation, coalescence or even phase separation (creaming).…”

Section: Discussionmentioning

confidence: 99%

Physicochemical stability assessment of all-in-one parenteral emulsion for neonates containing SMOFlipid

et al. 2012

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The aim of the study was to assess the stability of all-in-one (AIO) parenteral admixture used for neonates, containing SMOFlipid, an alternative to soybean, an α-tocopherol-enriched lipid emulsion. SMOFlipid, consisting of soybean oil, medium chain triglycerides, olive oil and fish oil, was introduced commercially in 2005. Stability assays consisted of the assessment of the admixture's macroscopic aspect, droplet size distribution, pH, peroxide value and α-tocopherol concentration. The admixture was stored at room temperature or at 4°C and analysed over time (0, 24 and 48 h). The SMOFlipid-containing AIO parenteral admixture was shown to be physicochemically stable. All changes were reversible, the droplet size was under the upper limit (0.5 µm) set by the US Pharmacopeia, maximum loss for vitamin E was 25% and the lipid peroxidation occurred within 24 h after preparation. In conclusion, the addition of SMOFlipid to an AIO parenteral admixture for neonates did not affect its physicochemical stability, and it was safe for administration on the first day of its preparation.

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Effects of intralipid infusion on blood viscosity and other haemorheological parameters in neonates and children

Abstract: Previously described deleterious effects of intralipid on circulation can not be explained by changes in haemorheological properties.

Cited by 14 publications

References 26 publications

Effects of Intralipid infusion on hemorheology and peripheral resistance in neonates and children

Effects of Intralipid infusion on hemorheology and peripheral resistance in neonates and children

An update on parenteral lipids and immune function: only smoke, or is there any fire?

Physicochemical stability assessment of all-in-one parenteral emulsion for neonates containing SMOFlipid

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