Effects of intraduodenal administration of tarazepide on pancreatic secretion and duodenal EMG in neonatal calves

Development of gastrointestinal and pancreatic functions in mammalians (mainly bovine and porcine species): influence of age and ingested food

“…However, according to our recent studies on neonatal conscious calves during the first week and to those of Pierzynowski et al [100] during the first 2 weeks in piglets, intravenous infusion of CCK does not seem to affect pancreatic secretion. In contrast, intraduodenal administration of CCK-A receptor antagonist reduces pancreatic secretion suggesting the involvement of some mucosal duodenal mechanism for pancreatic secretion (figure 2), and alters intestinal mucosa morphology [5,150,153]. During the first postnatal week, a rapid decrease in gastrin concentration could favor chymosin reduction and a steady-state in pepsin and HCI secretion since gastrin stimulates pepsin and acid secretion [35,128].…”

The effect of exogenous leptin on pancreatic enzyme secretion in anaesthetized rats

“…Intravenous infusions of pentagastrin or secretin caused an immediate increase in circulating leptin levels and leptin release into the gastric juice in humans (Sobhani et al, 2000). The role of leptin released into the gastric lumen on the secretion of pancreatic juice remains unclear, though inhibition by luminal somatostatin (Konturek et al, 1981), and stimulation by luminal CCK-8 (Zabielski et al, 1998) have been demonstrated in whole animal studies.…”

The apelin-13 influences the activity of pancreatic enzymes in young rats

“…Increased CCK concentration in blood in our experiment may be connected with stimulating actions of apelin on neurohormonal mediators and neurotransmitters, which activates CCK secretion. It was also previously found that regulatory peptides including apelin (Wang et al, 2009), leptin (Sobhani et al, 2002), ghrelin (Kapica et al, 2006;Nawrot-Porąbka et al, 2007) and obestatin (Kapica et al, 2007) when secreted into the gastric lumen, may reach the intestinal lumen and stimulate CCK secretion (Zabielski et al, 1998). In studies it was observed that apelin stimulated CCK secretion from a murine enteroendocrine cell line by mitogen-activated protein kinase (MAPK) pathway.…”