Effects of Intracranial Dopamine Perfusion: Behavioural Arousal and Reversal of Cerebral Arterial Spasm following Surgery for Clipping of Ruptured Cerebral Aneurysms

Boullin, D J; Adams, C.; Mohan, John; Green, A R; Hunt, T M; Boulay, G. H. du; Rogers, AT

doi:10.1177/00359157770700s211

Cited by 12 publications

(11 citation statements)

References 28 publications

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“…The failure to find sufficient conversion of PGH2 to PGI2 to relax any baboon cerebral artery except the vertebral in the current work, reinforces the view that prostaglandin endoperoxides may exert direct effects on cerebral vessels. An alternative possibility is that, in the absence of prostacyclin synthetase, prostaglandin endoperoxides are transformed rapidly to PGE2 which is a potent constrictor of human and baboon cerebral arteries (Boullin et al, 1976(Boullin et al, , 1977. It is not possible to determine the significance of prostacyclin synthetase in relation to responses of cerebral arteries without an extended study in different species.…”

Section: Discussionmentioning

confidence: 99%

“…To test the effects of drugs the arteries were dissected spirally and mounted in a 10 ml isolated organ bath. Further 677 details are given in previous papers (Starling et al, 1975;Boullin et al, 1976Boullin et al, , 1977. Isotonic contractions of the muscles were amplified by transducer and recorded as previously described.…”

Section: Isolated Arteriesmentioning

confidence: 99%

“…We have previously reported the effects of dopamine and 5-HT on human and baboon isolated cerebral arteries (Boullin et al, 1977) and these will not be described in detail here.…”

Section: Comparison With Other Drugsmentioning

confidence: 99%

“…In addition prostacyclin is one of the most potent inhibitors of platelet aggregation known. The potential therapeutic applications of the use of this drug or more stable analogues is currently under study (Moncada and Vane, 1978).In view of its potent relaxing actions on human and baboon cerebral arteries (Boullin et al, 1979) prostacyclin may be of use in the prevention or reversal of cerebral arterial vasospasm which commonly occurs after the rupture of aneurysms of the major cerebral arteries.Before any clinical studies it is of course necessary to examine the actions of prostacyclin and precursors (prostaglandin endoperoxides, PGG2, PGH2) upon the cerebral vasculature of animals.For some years we have been using the baboon as a model for studying the aetiology of human vasospasm (see Boullin et al, 1977.Accordingly it was relevant to test the effects of prostacyclin and PGH2 on this system. In this paper we describe their effects on baboon arteries in vitro and in vivo after systemic administration and visualisation by carotid angiography.…”

mentioning

confidence: 99%

“…For some years we have been using the baboon as a model for studying the aetiology of human vasospasm (see Boullin et al, 1977.…”

mentioning

confidence: 99%

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Responses of baboon cerebral and extracerebral arteries to prostacyclin and prostaglandin endoperoxide in vitro and in vivo.

Jarman¹,

Boulay²,

Kendall³

et al. 1979

Journal of Neurology, Neurosurgery & Psychiatry

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S U M M A R Y The responses of baboon cerebral and extracerebral arteries to prostaglandin endoperoxide (PGH2) and prostacyclin (PGI2) were investigated on isolated arteries and in vivo by serial angiography. Both PGH2 and PGI2 could produce dose-dependent contraction or relaxation of isolated arteries. PGH2 induced relaxation was indicative of prostacyclin synthetase activity, the enzyme which converts PGH2 to PGI2. In isolated arteries tested one to four hours post mortem only the vertebral artery showed prostacyclin synthetase activity. Thus PGH2 induced contraction of cerebral arteries may be indicative of a physiological function. Vasomotor tone may in part be the result of a balance between PGH2 constriction and PGI2 dilatation. In vivo PGI2 infusion caused pronounced and prolonged dilatation of cerebral arteries, which lasted longer than the cardiovascular changes. As PGI2 is the most potent cerebral vasodilator drug tested, it may be of clinical use in the treatment of cerebral vasospasm.Prostacyclin is a recently discovered prostaglandin with potent vasodilator effects on peripheral and central blood vessels. In addition prostacyclin is one of the most potent inhibitors of platelet aggregation known. The potential therapeutic applications of the use of this drug or more stable analogues is currently under study (Moncada and Vane, 1978).In view of its potent relaxing actions on human and baboon cerebral arteries (Boullin et al., 1979) prostacyclin may be of use in the prevention or reversal of cerebral arterial vasospasm which commonly occurs after the rupture of aneurysms of the major cerebral arteries.Before any clinical studies it is of course necessary to examine the actions of prostacyclin and precursors (prostaglandin endoperoxides, PGG2, PGH2) upon the cerebral vasculature of animals.For some years we have been using the baboon as a model for studying the aetiology of human vasospasm (see Boullin et al., 1977.

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Section: Discussionmentioning

confidence: 99%

Section: Isolated Arteriesmentioning

confidence: 99%

“…We have previously reported the effects of dopamine and 5-HT on human and baboon isolated cerebral arteries (Boullin et al, 1977) and these will not be described in detail here.…”

Section: Comparison With Other Drugsmentioning

confidence: 99%

mentioning

confidence: 99%

“…For some years we have been using the baboon as a model for studying the aetiology of human vasospasm (see Boullin et al, 1977.…”

mentioning

confidence: 99%

See 3 more Smart Citations

Responses of baboon cerebral and extracerebral arteries to prostacyclin and prostaglandin endoperoxide in vitro and in vivo.

Jarman¹,

Boulay²,

Kendall³

et al. 1979

Journal of Neurology, Neurosurgery & Psychiatry

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Reversal of cerebral arterial spasm by intrathecal administration of a calcium antagonist (nimodipine)

et al. 1984

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Specific antagonists to the influx of calcium, necessary for the excitation-contraction coupling process in arterial smooth muscle, are potentially useful in the treatment of cerebral vasospasm but systemic hypotension might limit their clinical applicability. We studied the effect of the calcium antagonist nimodipine (BAY e 9736) on cerebral arterial spasm, intraventricular pressure and blood pressure (BP), when administered into the cerebral ventricles of the dog. Cerebral vasospasm was produced by the injection of autologous blood into the cisterna magna. In a group of 8 dogs, 100 micrograms of nimodipine was injected into the lateral ventricle. The effect of the drug on the basilar artery was monitored angiographically. Nimodipine always relieved spasm, and often the relaxation surpassed the resting vessel diameter. In a control group, the injection of placebo did not relax the spastic arteries. Determinations using gas chromatography of nimodipine in CSF and blood demonstrated that a concentration of 1 microgram/ml in cisternal CSF was sufficient to reduce spasm while concomitant plasma concentrations of 0.004 micrograms/ml did not result in significant BP reduction.

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Inotropic drugs in acute circulatory failure

Herbert

Tinker

1980

Intensive Care Med

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The use of inotropic drugs in patients requiring acute circulatory support is reviewed. A knowledge of their various peripheral effects is essential if the appropriate drug is to be used. The place or pressor amines, digitalis, salbutamol and glucagon in the treatment of patients with poor tissue perfusion is limited. Of the catecholamines, adrenaline causes excessive renal vasoconstriction and peripheral gangrene, noradrenaline increase myocardial work and diminishes peripheral perfusion and isoprenaline distributes blood away from the vital organs, namely: brain, kidneys, heart and mesentery. Dopamine is a useful agent as it enhances renal blood flow in low doses and is not excessively chronotropic. Dobutamine has not yet been shown to have significant advantages over other inotropes and requires further examination.

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Effects of Intracranial Dopamine Perfusion: Behavioural Arousal and Reversal of Cerebral Arterial Spasm following Surgery for Clipping of Ruptured Cerebral Aneurysms

Cited by 12 publications

References 28 publications

Responses of baboon cerebral and extracerebral arteries to prostacyclin and prostaglandin endoperoxide in vitro and in vivo.

Responses of baboon cerebral and extracerebral arteries to prostacyclin and prostaglandin endoperoxide in vitro and in vivo.

Reversal of cerebral arterial spasm by intrathecal administration of a calcium antagonist (nimodipine)

Inotropic drugs in acute circulatory failure

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