Effects of intracoronary injection of acetylcholine on coronary arterial hemodynamics and diameter

Horio, Yutaka; Yasue, Hirofumi; Okumura, Ken; Takaoka, Kyoji; Matsuyama, Koshi; Gotō, Kazuo; Minoda, Koutaro

doi:10.1016/0002-9149(88)90887-9

Cited by 44 publications

(10 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Finally, GTN or isosorbide dinitrate was infused to relieve spasm and examine organic lesions. [12][13][14] The specificity of this test for variant angina was 99%.…”

Section: Angiographic Documentation Of Coronary Spasmmentioning

confidence: 84%

“…Coronary spasm was induced by the intracoronary injection of ACh (Daiichi-Sankyo Co, Tokyo, Japan) after diagnostic catheterization in the morning. [12][13][14] ACh dissolved in 5 mL of warmed 0.9% saline was infused manually over 20 seconds into the left coronary artery in incremental doses of 10, 20, 50, and 100 μg and then 10, 20, and 50 μg into the right coronary artery depending on the vascular reactivity in 20 seconds under the continuous monitoring of 12-lead ECG and blood pressure with a temporary pacemaker in place in the morning. These doses of ACh corresponded with 2×10 −6 to 10 −5 mol/L.…”

Section: Angiographic Documentation Of Coronary Spasmmentioning

confidence: 99%

“…These doses of ACh corresponded with 2×10 −6 to 10 −5 mol/L. 13 Coronary angiography was performed 1 minute after each ACh injection or when ischemic ECG changes appeared. Coronary spasm induced by this method usually disappeared spontaneously within 1 to 2 minutes, and both the left and right coronary arteries could be examined separately unless severe spasm occurred in the left coronary artery and necessitated the prompt injection of GTN or isosorbide dinitrate into the artery.…”

Section: Angiographic Documentation Of Coronary Spasmmentioning

confidence: 99%

See 2 more Smart Citations

East Asian Variant of Aldehyde Dehydrogenase 2 Is Associated With Coronary Spastic Angina

et al. 2015

Self Cite

View full text Add to dashboard Cite

Background-Coronary spastic angina (CSA) is a common disease among East Asians, including Japanese. The prevalence of alcohol flushing syndrome associated with deficient activity of the variant aldehyde dehydrogenase 2 (ALDH2*2) genotype is prevalent among East Asians. We examined whether CSA is associated with the ALDH2*2 genotype in Japanese. Methods and Results-The study subjects consisted of 202 patients in whom intracoronary injection of acetylcholine was performed by angiography on suspicion of CSA (119 men and 83 women; mean age, 66.2±11.4 years). They were divided into CSA (112 patients) and control groups (90 patients). ALDH2 genotyping was performed by the direct application of the TaqMan polymerase chain reaction system on dried whole blood. Clinical and laboratory data were examined using conventional methods. The frequencies of male sex, ALDH2*2 genotype carriers, alcohol flushing syndrome, tobacco smoking, and the plasma level of uric acid were higher (P<0. 001, P<0.001, P<0.001, P<0.001, and P=0.007, respectively) and the plasma high-density lipoprotein cholesterol levels were lower (P<0.001) in the CSA group than in the control group. The multivariable logistic regression analysis revealed that ALDH2*2 genotype and smoking were significantly associated with CSA (P<0.001 and P=0.024, respectively). Conclusions-East Asian variant ALDH2*2 genotypes and, hence, deficient ALDH2 activity were associated with CSA in Japanese. These data support further investigation of treatment targeting aldehydes for CSA. (Circulation.

show abstract

“…Finally, GTN or isosorbide dinitrate was infused to relieve spasm and examine organic lesions. [12][13][14] The specificity of this test for variant angina was 99%.…”

Section: Angiographic Documentation Of Coronary Spasmmentioning

confidence: 84%

Section: Angiographic Documentation Of Coronary Spasmmentioning

confidence: 99%

Section: Angiographic Documentation Of Coronary Spasmmentioning

confidence: 99%

See 1 more Smart Citation

East Asian Variant of Aldehyde Dehydrogenase 2 Is Associated With Coronary Spastic Angina

et al. 2015

Self Cite

View full text Add to dashboard Cite

show abstract

“…The discrepancy between the present results and those of these previous two reports may be due to the differences in size of the vessels studied (conductance vs. resistance). It has been suggested that vasomotor response to Ach may vary between conductance artery (vasospasm) and resistance artery (vasodilation) in the coronary vascular bed in VAP [6, 7]. …”

Section: Discussionmentioning

confidence: 99%

“…Horio et al [6]reported that, in patients with VAP, acetylcholine (Ach) induced vasoconstriction in the epicardial artery, whereas it increased coronary sinus blood flow significantly. Similarly, Okumura et al [7]have demonstrated that although the cross-sectional area of epicardial artery in VAP was reduced after intra-coronary infusion of Ach, calculated coronary blood flow was significantly increased.…”

Section: Introductionmentioning

confidence: 99%

Endothelium-Dependent Vasodilator Response Is Augmented in Peripheral Resistance Vessels of Patients with Vasospastic Angina

et al. 1999

View full text Add to dashboard Cite

Although the mechanism underlying coronary conduit artery spasm in vasospastic angina (VAP) remains unknown, coronary endothelial dysfunction has been suggested as playing an important role. However, it remains unknown whether this endothelium-mediated abnormal vasomotion is uniformly evident irrespective of site of vascular bed or vessel size. Plethysmographic studies were carried out to measure changes in forearm resistance vessel blood flow (FBF) induced by acetylcholine (Ach), sodium nitroprusside, and 10-min occlusion-induced reactive hyperemia in 12 patients with VAP, 14 patients with atherosclerotic (>75% fixed stenosis) coronary artery disease (CAD), and 16 healthy controls. FBF responses induced by the endothelium-dependent vasodilator Ach were significantly augmented in patients with VAP compared to controls, whereas this type of FBF response in patients with CAD was significantly blunted (at the maximum dose: VAP, 24.1 ± 3.0; controls, 17.2 ± 1.9; CAD, 12.8 ± 1.9 ml/min per 100 ml; p < 0.01). However, there were no significant differences in FBF responses during infusion of sodium nitroprusside among the three subject groups. Reactive hyperemic FBF which represents maximum vasodilatory capacity did not differ among the three. To assess the role of nitric oxide in the augmented endothelium-dependent response in VAP, Ach-induced FBF response was determined before and after administration of the nitric oxide synthase inhibitor N^G-monomethyl-L-arginine in another VAP group (n = 7). After nitric oxide synthase inhibition, the peak FBF response induced by Ach decreased from 23.3 ± 3.2 to 14.1 ± 1.6 ml/min per 100 ml (p < 0.05). In conclusion, the above data suggest that endothelium-dependent vasomotor response to Ach in limb resistance vessels is augmented in patients with vasospastic angina. It seems unlikely that endothelial function is consistently depressed in any area of the vascular bed in this disorder.

show abstract

Physiology of Vasospastic Disorders

Musicant¹,

Roullet²,

Edwards³

et al. 2005

Vascular Surgery

View full text Add to dashboard Cite

Effects of intracoronary injection of acetylcholine on coronary arterial hemodynamics and diameter

Cited by 44 publications

References 13 publications

East Asian Variant of Aldehyde Dehydrogenase 2 Is Associated With Coronary Spastic Angina

East Asian Variant of Aldehyde Dehydrogenase 2 Is Associated With Coronary Spastic Angina

Endothelium-Dependent Vasodilator Response Is Augmented in Peripheral Resistance Vessels of Patients with Vasospastic Angina

Physiology of Vasospastic Disorders

Contact Info

Product

Resources

About