Objective: To investigate whether transthoracic Doppler echocardiography (TTE) can reliably measure the coronary flow reserve in the left anterior descending coronary artery in children with Kawasaki disease. Design: Coronary flow velocity in the distal left anterior descending coronary artery was measured by TTE and was compared with that obtained by intracoronary Doppler guide wire. The ratio of maximum hyperaemia (intravenous administration of adenosine triphosphate, 160 µg/kg/min) to baseline peak (mean) diastolic coronary flow velocity in the distal artery was used as an estimate of coronary flow reserve. Setting: University hospital. Patients: 10 patients with significant left anterior descending coronary stenosis (> 70% diameter stenosis) (group A) in the proximal or middle portion of the artery and 14 patients (group B) without significant stenosis, all with Kawasaki disease documented by previous coronary angiography. Results: The reduced hyperaemic coronary flow velocity in group A compared with group B resulted in a markedly lower coronary flow reserve, derived from both peak diastolic velocity and mean diastolic velocity by either technique of investigation. Multivariate analysis identified the best predictor of left anterior descending coronary artery stenosis to be a coronary flow reserve of < 2.2, derived from mean diastolic flow velocity measured using TTE (sensitivity 90%, specificity 100%, accuracy 96%). A good correlation was found between diastolic velocity derived values for coronary flow reserve measured using both TTE and Doppler guide wire (r = 0.92, p = 0.0001). Conclusions: Coronary flow reserve in the distal left anterior descending coronary artery can be accurately measured using TTE without any intravascular instrumentation in children with Kawasaki disease.F unctional impairment of a coronary artery can be assessed by measuring coronary flow reserve-that is, the capacity of the artery to allow increased blood flow when needed. The concept of coronary flow reserve is receiving increased attention because of its clinical and physiological importance.1 Measurements of coronary flow velocity and flow reserve during cardiac catheterisation were first done by Wilson et al in 1985, 2 and since then intracoronary Doppler guide wire recording has been shown to be a highly accurate way of measuring coronary flow velocity, and has been used for evaluating various clinical problems. Recent studies have suggested that blood flow velocity in the proximal left anterior descending coronary artery can be determined by transoesophageal Doppler echocardiography.
5-7Furthermore, new developments in ultrasound technology now enable low velocity flow signals in the epicardial coronary arteries to be detected by colour and pulsed Doppler echocardiography from transthoracic windows, though the value of these procedures has not yet been established in any large series of cases. [8][9][10] If measurements of intracoronary flow velocity by transthoracic echocardiography (TTE) could be shown to be equivalent...