Effects of intra‐articular hyaluronic acid injection on immunohistochemical characterization of joint afferents in a rat model of knee osteoarthritis

Ikeuchi, Masahiko; Izumi, Masashi; Aso, Koji; Sugimura, Natsuki; Kato, Tomonari; Tani, Tohru

doi:10.1002/ejp.551

Cited by 25 publications

(21 citation statements)

References 53 publications

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“…They reported that intra-articular HA injection reduced OA severity, decreased paw mechanical hyperalgesia, and attenuated OA-associated upregulation of calcitonin gene-related peptide (CGRP). However, no studies have investigated the effects of HA on pain relief in a model of ankle OA 42. In our study, significant mechanical hypersensitivity (ie, allodynia) was observed in the MIA rats, but not in the MIA-HA rats, 14 days after MIA injection.…”

Section: Discussionmentioning

confidence: 48%

Antinociceptive effects of hyaluronic acid on monoiodoacetate-induced ankle osteoarthritis in rats

Jimbo¹,

Terashima²,

Teramoto³

et al. 2019

JPR

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PurposeAnkle osteoarthritis (OA) causes significant pain and debilitation; yet, its underlying mechanisms remain unclear. Clinically, hyaluronic acid (HA) is widely used to treat OA. The present study aimed to investigate the roles of HA in pain-related behavior, joint function, swelling, and pathological changes in cartilage in a rat model of monoiodoacetate (MIA)-induced ankle OA.Materials and methodsMale Sprague Dawley rats were assigned to three experimental groups as follows: 1) MIA rats injected with 1 mg MIA in the right tibiotarsal joint for two consecutive days; 2) sham rats injected with saline instead of MIA; and 3) MIA-HA rats injected with HA in the tibiotarsal joint at 7, 14, and 21 days after MIA injection. Joint swelling, range of motion (ROM), and pain-related behavior were evaluated 1 day before and on the 7th, 14th, 21st, and 28th day after MIA or saline injection. Pathological changes in the ankle joint were assessed 28 days after MIA or saline injection.ResultsNo significant difference in the degree of ankle swelling or ROM reduction was observed between MIA rats and MIA-HA rats. However, compared with those in MIA rats, mechanical and thermal hypersensitivity was significantly reduced and stride length significantly improved in MIA-HA rats. Histologic analysis revealed that cartilage degeneration was significantly suppressed in MIA-HA rats compared with that in MIA rats, reflecting the chondroprotective effects of HA.ConclusionHA improved pain-related behavior and stride length and suppressed MIA-induced cartilage degeneration. HA may thus inhibit OA progression and suppress peripheral and/or central sensitization.

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Section: Discussionmentioning

confidence: 48%

Antinociceptive effects of hyaluronic acid on monoiodoacetate-induced ankle osteoarthritis in rats

Jimbo¹,

Terashima²,

Teramoto³

et al. 2019

JPR

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“…In an IA mono-iodoacetate (MIA) model of knee OA in rats, IA Supartz FX decreased pain-related behavior as well as the number of pain-transmitting cells in the dorsal root ganglion, as determined by marker for calcitonin gene-related peptide (CGRP). 30 Further in vitro experiments indicated that Supartz FX decreased COX-2 mRNA levels in synoviocytes and chondrocytes 5 , 23 (Suppl. Table S7).…”

Section: Resultsmentioning

confidence: 99%

Review of the Mechanism of Action for Supartz FX in Knee Osteoarthritis

2016

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ObjectiveSummarize the biologic effects of Supartz FX for knee osteoarthritis (OA), the first worldwide clinically approved intra-articular (IA) hyaluronic acid (HA) product.DesignTo determine the mechanism of action from preclinical and clinical studies, a literature search was conducted of Supartz FX using academic databases from 1987 to 2016. Articles on Supartz FX that deal with its mechanisms of action were extracted, categorized, and reviewed.ResultsSupartz FX has 2 potential mechanisms of action: (1) biomechanical: IA Supartz FX directly improves the viscoelasticity and lubrication of synovial fluid; (2) physiologic: IA Supartz FX penetrates synovium and cartilage tissues to reach HA receptors on the surface of synoviocytes and chondrocytes. In synovium, suppression of gene expression in inflammatory mediators results in improved endogenous HA production, improved properties of synovial fluid, and reduction in pain. In cartilage, suppression of gene expression of collagenases and aggrecanases suppresses cartilage degeneration.ConclusionThe net results of basic and clinical studies is that IA Supartz FX provides a more favorable biomechanical and functional environment in the knee joint. Hence, it is not only a lubricant but is also physiologically active. These actions may help explain both short- and long-term improvement in pain and function often achieved from IA Supartz FX in knee OA.

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“…In fact, several animal studies on OA pain reported similar findings on the HA effect. Ikeuchi et al employed a monoiodoacetate (MIA)-induced OA pain model and found no significant difference in weight-bearing asymmetry in HA-treated rats [54]. Boettger et al also demonstrated in a rat bradykinin/PGE2 pain model that HA lost its antinociceptive efficacy (shown as weight-bearing asymmetry) from day 7 after injection [55].…”

Section: Discussionmentioning

confidence: 99%

Shea Nut Oil Extracts Enhance the Intra-Articular Sodium Hyaluronate Effectiveness on Surgically Induced OA Progression in Rats

Chen

Wong

2020

Nutrients

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Osteoarthritis (OA) progression is associated with joint pain and stiffness. Intra-articular hyaluronic acid (IAHA) injection in knee OA restores the viscoelasticity of the joint and prevents cartilage damage. Shea nut oil extract (SNO) was shown to provide chondroprotection on surgically-induced OA progression in rats. Here we aim to examine IAHA injection supplemented with SNO diet for a synergetic evaluation on the disease progression in OA rats. We employed an anterior cruciate ligament transection plus medial meniscectomy-induced knee OA rat model with up to 12 weeks of sign/behavior observation (knee width, weight-bearing) and histological assessments of joint damage. We found both IAHA and SNO alone significantly attenuated histological changes of cartilage degeneration and synovial reactions in these knee OA rats. Nonetheless, oral SNO alone mitigated OA pain and inflammation while IAHA alone had no significant impact on the weight-bearing test and knee joint swelling. Moreover, with IAHA-treated rats fed with oral SNO diet, additional anti-inflammatory and anti-nociceptive effects were found, which further enhanced and maintained IAHA protection. Given the differential phenotype of oral SNO vs. IAHA, a regimen of IAHA coupled with SNO supplement provides a long-term effect of IAHA treatment. Taken together, the SNO supplement can be safely used as an adjuvant diet for chronic symptomatic relief of OA coupled with IAHA management.

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Effects of intra‐articular hyaluronic acid injection on immunohistochemical characterization of joint afferents in a rat model of knee osteoarthritis

Cited by 25 publications

References 53 publications

Antinociceptive effects of hyaluronic acid on monoiodoacetate-induced ankle osteoarthritis in rats

Antinociceptive effects of hyaluronic acid on monoiodoacetate-induced ankle osteoarthritis in rats

Review of the Mechanism of Action for Supartz FX in Knee Osteoarthritis

Shea Nut Oil Extracts Enhance the Intra-Articular Sodium Hyaluronate Effectiveness on Surgically Induced OA Progression in Rats

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