IntroductionPoor medication adherence is common in children and adolescents with chronic illness, but there is uncertainty about the best way to enhance medication adherence in this group. The authors conducted a systematic review of controlled trials examining interventions that aim to improve medication adherence. Method A comprehensive literature search was undertaken to locate controlled trials that described specifi c interventions aiming to improve adherence to long-term medication, where participants were aged 18 years and under, medication adherence was reported as an outcome measure, and which could be implemented by individual health practitioners. Studies were reviewed for quality and outcome. Results 17 studies met inclusion criteria: seven studies examined educational strategies, seven studies examined behavioural interventions and three studies examined educational intervention combined with other forms of psychological therapies. Only two of seven studies reported a clear benefi t for education on medication adherence, whereas four of seven trials indicated a benefi t of behavioural approaches on medication adherence. One trial reported that combining education with behavioural management may be more effective than education alone. Studies which combined education with other non-medication specifi c psychological interventions failed to demonstrate a benefi cial effect on medication adherence. Only two studies examined adherencepromoting interventions in young people with established adherence problems. Conclusion These fi ndings suggest that education interventions alone are insuffi cient to promote adherence in children and adolescents, and that incorporating a behavioural component to adherence interventions may increase potential effi cacy. Future research should examine interventions in high-risk groups.
INTRODUCTIONAdherence has been defi ned as 'the extent to which a person's behaviour corresponds with agreed recommendations from a healthcare provider'. 1 Medication adherence refers to the degree to which the medications taken refl ect the prescriber's intention. 2 3 Poor medication adherence is common, especially in chronic illness, 1 3 4 and is associated with poorer outcomes. 3 5 6 Interventions to promote adherence may be effective, although benefi ts are not consistently demonstrated across studies. 4 A systematic review of interventions to enhance medication adherence in children and adolescents with chronic illness Angela J Dean, 1-3 Julie Walters, 4 Anthony Hall 4,5Most existing reviews of adherence-promoting interventions have focused on adults. However, many young people experience chronic illness 7 8 and poor medication adherence. 9-12 Involvement of families in medication routines, 12 13 and varying developmental capacities of children and adolescents 11 12 14 15 may infl uence medication adherence, reinforcing the need to identify interventions with demonstrated effi cacy in young people rather than translating fi ndings from adult research. 9 11 A review of interven...