Effects of internal limiting membrane peeling during vitrectomy for macula-off primary rhegmatogenous retinal detachment

Blanco-Teijeiro, María José; Rodriguez, Manuel Bande; Cuñarro, Raquel Mansilla; Fernández, Laura Paniagua; Ruiz, Francisco Ruiz-Oliva; Ces, Antonio Piñeiro

doi:10.1177/1120672117750055

Cited by 12 publications

(23 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Eight were retrospective and one was an RCT, which was conducted by Eissa et al [ 6 ] and enrolled only macula off RD. Similarly, Garweg et al [ 8 ], Foveau et al [ 10 ], Blanco-Teijeiro et al [ 11 ] and Aras et al [ 9 ] included only macula off RD. The rate of macula off RD recorded by Rao et al [ 7 ], Nam et al [ 3 ], Akiyama et al [ 5 ] and Forlini et al [ 4 ] was 74%, 44%, 42% and 68%, respectively.…”

Section: Resultsmentioning

confidence: 99%

“…The rate of macula off RD recorded by Rao et al [ 7 ], Nam et al [ 3 ], Akiyama et al [ 5 ] and Forlini et al [ 4 ] was 74%, 44%, 42% and 68%, respectively. Eissa et al [ 6 ], Garweg et al [ 8 ] and Aras et al [ 9 ] used silicone oil as endotamponade in all cases, while Foveau et al [ 10 ], Blanco-Teijeiro et al [ 11 ], Rao et al [ 7 ] and Nam et al [ 3 ] performed vitrectomy with gas in each case. Forlini et al [ 4 ] used both tamponades.…”

Section: Resultsmentioning

confidence: 99%

“…Akiyama et al [ 5 ] did not report on type of tamponade. Baseline visual acuity was also different: Nam et al [ 3 ] and Akiyama et al [ 5 ] registered a mean BCVA < 1 logMar in both the ILM peeling and non-ILM peeling group, while it was > 1 logMar in both groups of all other studies [ 4 , 6 – 11 ]. This difference in clinical aspects has to be taken into account as it might have an influence on outcomes, in particular on the functional one.…”

Section: Resultsmentioning

confidence: 99%

“…Consequently, ever-increasing attention has been paid to possible complications related to this surgery and how to limit unpleasant events. Macular epiretinal membrane (ERM) represents one of the most common visual impairing complications after vitrectomy for RRD repair, with an incidence reported between 6% and 48% [ 2 – 11 ] and further surgery required for ERM to be removed in one third of cases [ 12 ].…”

Section: Introductionmentioning

confidence: 99%

“…On this basis, some authors described ILM peeling during primary vitrectomy for RRD with the purpose of reducing ERM development [ 3 – 11 ]. These studies agree in demonstrating a significant reduction in the incidence of ERM after vitrectomy with peeling of the ILM, even though a clear discrepancy exists regarding the effect of peeling on visual acuity; in some of these studies, better visual results were reported in eyes receiving ILM peeling compared to non-ILM peeling, whereas in others no difference was found between the two procedures, and in the only randomized trial, a significantly worse functional result was described after ILM peeling [ 3 – 11 ].…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Internal limiting membrane peeling versus no peeling during primary vitrectomy for rhegmatogenous retinal detachment: A systematic review and meta-analysis

et al. 2018

View full text Add to dashboard Cite

BackgroundInternal limiting membrane (ILM) peeling during primary vitrectomy for rhegmatogenous retinal detachment (RRD) prevents the formation of postoperative macular epiretinal membrane (ERM). However, studies that compared vitrectomy with and without ILM peeling for RRD, have reported controversial outcomes.ObjectiveTo assess the efficacy of ILM peeling versus non-ILM peeling during vitrectomy for RRD by a systematic review and meta-analysis of published studies.MethodsPubMed, Medline, Web of Science, Embase databases, and the Cochrane Library were searched up to April 2018 to identify studies that compared primary vitrectomy with and without ILM peeling for RRD with at least six months follow-up. Primary outcomes were the rate of postoperative ERM formation and mean best corrected visual acuity (BCVA) change after vitrectomy. Rate of recurrence of retinal detachment (RD) was assessed as secondary outcome. Risk ratios (RRs) with 95% confidence intervals (CIs) expressed pooled results for rate of ERM formation and rate of RD recurrence in ILM peeling and non-ILM peeling groups. Pooled results for BCVA change in the two groups were expressed as Weighted Mean Difference (WMD) with 95% CIs.ResultsNine studies, one of which was a randomized controlled trial (RCT), with a total number of 404 eyes in the ILM peeling group and 365 eyes in the non-ILM peeling group, were included. The analysis from pooled data indicated a significant lower rate of postoperative ERM formation in the ILM peeling group compared to the non-ILM peeling group (9 studies, 769 eyes, RR = 0.14; CI: 0.07 to 0.28; P < 0.001). There was no statistical difference in mean BCVA change (9 studies, 769 eyes, WMD = 0.02; CI: -0.11 to 0.16; P = 0.75). Rate of recurrence of RD was lower in the ILM peeling group (6 studies, 603 eyes, RR = 0.32; CI = 0.17 to 0.61; P< 0.001).ConclusionILM peeling during vitrectomy for RRD prevents the formation of macular epiretinal membrane postoperatively and reduces the incidence of RD recurrence, but better visual outcome was not found compared to non-ILM peeling vitrectomy.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Internal limiting membrane peeling versus no peeling during primary vitrectomy for rhegmatogenous retinal detachment: A systematic review and meta-analysis

et al. 2018

View full text Add to dashboard Cite

show abstract

Anatomical and functional results of ILM peeling vs. non-peeling in macula-off rhegmatogenous retinal detachment

Sousa

Calvão-Santos

Costa

et al. 2020

Graefes Arch Clin Exp Ophthalmol

View full text Add to dashboard Cite

Primary ILM peeling during retinal detachment repair: a systematic review and meta-analysis

Lamas-Francis

Bande-Rodríguez

Blanco-Teijeiro

2023

Sci Rep

Self Cite

View full text Add to dashboard Cite

Epiretinal membrane (ERM) formation is a known postoperative complication following retinal detachment (RD) repair surgery. Prophylactic peeling of the internal limiting membrane (ILM) during surgery has been shown to reduce the risk of developing postoperative ERM formation. Some baseline characteristics and degrees of surgical complexity may act as risk factors for ERM development. In this review we aimed to investigate the benefit of ILM peeling in patients without significant proliferative vitreoretinopathy (PVR) who underwent pars plana vitrectomy for RD repair. A literature search using PubMed and various keywords retrieved relevant papers from which data were extracted and analyzed. Finally, the results of 12 observational studies (3420 eyes) were summarized. ILM peeling significantly reduced the risk of postoperative ERM formation (RR = 0.12, 95% CI 0.05–0.28). The groups did not differ in final visual acuity (SMD 0.14 logMAR (95% CI − 0.03–0.31)). The risk of RD recurrence (RR = 0.51, 95% CI 0.28–0.94) and the need for secondary ERM surgery (RR = 0.05, 95% CI 0.02–0.17) were also higher in the non-ILM peeling groups. In summary, although prophylactic ILM peeling appears to reduce the rate of postoperative ERM, this benefit does not translate into consistent visual recovery across studies and potential complications must be considered.

show abstract

Effects of internal limiting membrane peeling during vitrectomy for macula-off primary rhegmatogenous retinal detachment

Abstract: Our results suggest that internal limiting membrane peeling during macula-off primary rhegmatogenous retinal detachment surgery can reduce the occurrence of postoperative epiretinal membrane, is safe, and results in favorable visual outcomes.

Cited by 12 publications

References 36 publications

Internal limiting membrane peeling versus no peeling during primary vitrectomy for rhegmatogenous retinal detachment: A systematic review and meta-analysis

Internal limiting membrane peeling versus no peeling during primary vitrectomy for rhegmatogenous retinal detachment: A systematic review and meta-analysis

Anatomical and functional results of ILM peeling vs. non-peeling in macula-off rhegmatogenous retinal detachment

Primary ILM peeling during retinal detachment repair: a systematic review and meta-analysis

Contact Info

Product

Resources

About