Effects of internal and external factors on the budgeting between defensive and non-defensive responses in Aplysia

Leod, Kaitlyn A. Mac; Seas, Alexandra; Wainwright, Marcy L.; Mozzachiodi, Riccardo

doi:10.1016/j.bbr.2018.04.040

Cited by 5 publications

(2 citation statements)

References 64 publications

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“…In Aplysia, s ensitization seems to represent a general behavioral state induced by pain, producing changes not only in reflexes but also across a spectrum of behaviors (e.g. Leod, Seas, Wainwright, & Mozzachiodi, 2018). We track sensitization memory by monitoring the tail-elicited siphon-withdrawal reflex (T-SWR), a defensive reflex of the siphon, a respiratory organ.…”

Section: Introductionmentioning

confidence: 99%

Transcriptional changes before and after forgetting of a long-term sensitization memory in Aplysia californica

Patel

Perez

Farrell

et al. 2018

Neurobiology of Learning and Memory

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Most long-term memories are forgotten, becoming progressively less likely to be recalled. Still, some memory fragments may persist, as savings memory (easier relearning) can be detected long after recall has become impossible. What happens to a memory trace during forgetting that makes it inaccessible for recall and yet still effective to spark easier re-learning? We are addressing this question by tracking the transcriptional changes that accompany learning and then forgetting of a long-term sensitization memory in the tail-elicited siphon withdrawal reflex of Aplysia californica. First, we tracked savings memory. We found that even though recall of sensitization fades completely within 1 week of training, savings memory is still detectable at 2 weeks post training. Next, we tracked the time-course of regulation of 11 transcripts we previously identified as potentially being regulated after recall has become impossible. Remarkably, 3 transcripts still show strong regulation 2 weeks after training and an additional 4 are regulated for at least 1 week. These long-lasting changes in gene expression always begin early in the memory process, within 1 day of training. We present a synthesis of our results tracking gene expression changes accompanying sensitization and provide a testable model of how sensitization memory is forgotten.

show abstract

Section: Introductionmentioning

confidence: 99%

Transcriptional changes before and after forgetting of a long-term sensitization memory in Aplysia californica

Patel

Perez

Farrell

et al. 2018

Neurobiology of Learning and Memory

View full text Add to dashboard Cite

show abstract

“…In Aplysia, sensitization seems to represent a general behavioral state induced by pain, producing changes not only in reflexes but also across a spectrum of behaviors (e.g. Leod, Seas, Wainwright, & Mozzachiodi, 2018). We track sensitization memory by monitoring the tail-elicited siphon-withdrawal reflex (T-SWR), a defensive reflex of the siphon, a respiratory organ.…”

Section: Sensitization Of the Tail-elicited Siphon Withdrawal Reflexmentioning

confidence: 99%

Transcriptional Changes Before and After Forgetting of a Long-Term Sensitization Memory in Aplysia californica

Calin-Jageman¹,

Calin‐Jageman²

2018

Preprint

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This is a pre-print of a paper now published in Neurobiology of Learning and Memory: https://doi.org/10.1016/j.nlm.2018.09.007 Most long-term memories are forgotten, becoming progressively less likely to be recalled. Still, some memory fragments may persist beyond forgetting, as savings memory (easier relearning) can persist long after recall has become impossible. What happens to a memory trace during forgetting that makes it inaccessible for recall and yet still effective to spark easier re-learning? We are addressing this question by tracking the transcriptional changes that accompany learning and then forgetting of a long-term sensitization memory in the tail-elicited siphon withdrawal reflex of Aplysia californica. First, we tracked savings memory. We found that even though recall of sensitization fades completely within 1 week of training, savings memory is still robustly expressed at 2 weeks post training. Next, we tracked the time-course of regulation of 11 transcripts we previously identified as potentially being regulated beyond the decay of recall. Remarkably, 3 transcripts still show strong regulation of expression 2 weeks after training and an additional 4 are regulated for at least 1 week. These long-lasting changes in gene expression always began early in the memory process, within 1 day of training. We present a synthesis of our results tracking gene expression changes accompanying sensitization and provide a testable model of how sensitization memory is forgotten.

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Role of nitric oxide in the induction of the behavioral and cellular changes produced by a common aversive stimulus in Aplysia

Farruggella

Acebo

Lloyd

et al. 2019

Behavioural Brain Research

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Effects of internal and external factors on the budgeting between defensive and non-defensive responses in Aplysia

Cited by 5 publications

References 64 publications

Transcriptional changes before and after forgetting of a long-term sensitization memory in Aplysia californica

Transcriptional changes before and after forgetting of a long-term sensitization memory in Aplysia californica

Transcriptional Changes Before and After Forgetting of a Long-Term Sensitization Memory in Aplysia californica

Role of nitric oxide in the induction of the behavioral and cellular changes produced by a common aversive stimulus in Aplysia

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