Effects of intermediate-conductance Ca2+-activated K+ channel modulators on human prostate cancer cell proliferation

Blockage of intermediate-conductance-Ca2+-activated K+ channels inhibits progression of human endometrial cancer

“…Furthermore, clotrimazole inhibits proliferation of human prostate cancer cell lines, such as LNCaP and PC-3 cells (Parihar et al, 2003). Consistent with these studies, the current work provides IKCa1 channels are responsible for the progression of EC ZH Wang et al new evidence that expression of IKCa1 was also increased in human EC.…”

“…Ion channels, including K þ channels, are important for cell cycle and cell proliferation and are found in a variety of cancer cells (Nilius and Wohlrab, 1992;Skryma et al, 1997;Ouadid-Ahidouch et al, 2000;Fraser et al, 2003;Parihar et al, 2003;Farias et al, 2004;Jager et al, 2004). It has been shown that K þ channels play a role in controlling proliferation and transformation of epithelial cells (Pardo et al, 1999).…”

KCNMA1 gene amplification promotes tumor cell proliferation in human prostate cancer

“…Interestingly, the intermediate conductance K þ channel (IK) rather than KCNMA1 has been proposed to be important for PC-3 and LNCaP cells by Parihar et al (2003). Parihar et al performed the efflux experiments under non-proliferative conditions, that is, in Ringer solution rather than in growth medium.…”

Migration-associated secretion of melanoma inhibitory activity at the cell rear is supported by KCa3.1 potassium channels

“…Since Ca 2+ -activated K + channels are expressed in most (if not all) cells possessing the ability to migrate, including leukocytes and many tumor cells, their roles in cell migration warrant close examination [18,[57][58][59][60][61][62][63]. In previous studies, it was described that the KCa3.1 channel is highly expressed in malignant melanoma cells [19].…”