Effects of interleukin 4 on human B-cell growth and differentiation

Banchereau, Jacques; Bidaud, Christine; Fluckiger, AC; Galibert, Laurent; Garrone, Pierre; Malisan, Florence; Pandrau, D.

doi:10.1016/s0923-2494(05)80010-0

Cited by 7 publications

(3 citation statements)

References 39 publications

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“…2 and Table I). This is a critical feature for a compound aimed at the development of immune interventions, because the activation of DC maturation is recognized as a key event in the stimulation of adaptive immune responses (49). Splenocytes ( Fig.…”

Section: Discussionmentioning

confidence: 99%

A Pegylated Derivative of α-Galactosylceramide Exhibits Improved Biological Properties

Ebensen

Link

Riese

et al. 2007

The Journal of Immunology

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The glycolipid α-galactosylceramide (αGalCer) has immunomodulatory properties, which have been exploited to combat cancer, chronic inflammatory diseases, and infections. However, its poor solubility makes αGalCer a suboptimal compound for in vivo applications. In this study, a pegylated derivative of αGalCer is characterized, which exhibits improved physical and biological properties. The new compound, αGalCerMPEG, is water-soluble and retains the specificity for the CD1d receptor of αGalCer. The in vitro stimulatory properties on immune cells (e.g., dendritic cells and splenocytes) are maintained intact, even when tested at a 33-fold lower concentration of the active moiety than αGalCer. NK cells isolated from mice treated with αGalCerMPEG also had stronger cytotoxic activity on YAC-1 cells than those obtained from animals receiving either αGalCer or CpG. Intranasal immunization studies performed in mice showed that αGalCerMPEG exerts stronger adjuvant activities than the parental compound αGalCer when tested at 0.35 vs 11.7 nM/dose. Coadministration of β-galactosidase with αGalCerMPEG resulted not only in high titers of Ag-specific Abs in serum (i.e., 1:512,000), but also in the stimulation of stronger Th2 and secretory IgA responses, both at local and remote mucosal effector sites (i.e., nose, lung, and vagina). The new synthetic derivative αGalCerMPEG represents a promising tool for the development of immune interventions against infectious and noninfectious diseases.

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Section: Discussionmentioning

confidence: 99%

A Pegylated Derivative of α-Galactosylceramide Exhibits Improved Biological Properties

Ebensen

Link

Riese

et al. 2007

The Journal of Immunology

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“…Interleukin-4 IL-4 is a pleiotropic cytokine produced by T cells, mast cells, and basophils and is known to regulate an array of functions in B cells, T cells, macrophages, hematopoietic and non-hematopoietic cells [146,147]. IL-4 serves as a key cytokine in driving Th2 differentiation and mediating humoral immunity, allergic responses and certain autoimmune diseases [148].…”

Section: Interleukinmentioning

confidence: 99%

Fish Cytokines and Immune Response

Reyes-Cerpa¹,

Maisey²,

Reyes-López³

et al. 2012

New Advances and Contributions to Fish Biology

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“…IL-4 is a crucial cytokine in the development of Th2 immune responses in mammals. It is mainly produced by T cells, mast cells and basophils; and is known to regulate several functions of B cells ( Banchereau et al, 1993 ; Finkelman and Urban, 2001 ; Mosmann et al, 1986 ). As previously reported ( Wang et al, 2016 ), neither IL-4/13A or IL-4/13B on their own were able to up-regulate IgM + B cell survival or proliferation ( Fig.…”

Section: Resultsmentioning

confidence: 99%

Distinct modes of action of CD40L and adaptive cytokines IL-2, IL-4/13, IL-10 and IL-21 on rainbow trout IgM+ B cells

Abós¹,

Wang

Secombes

et al. 2020

Developmental & Comparative Immunology

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In mammals, conventional B (B2) cells are activated within lymphoid follicles through a close relationship with T follicular helper (Tfh) cells. The interaction between CD40 expressed on B cells and its ligand (CD40L) expressed on Tfh cells is a key signal that regulates the formation of germinal centers (GCs), B cell survival, proliferation and differentiation to plasma cells (PCs) or memory cells. Additionally, certain soluble cytokines produced by T cells also strongly condition the outcome of this interaction. Despite the many differences found between fish B cells and mammalian B2 cells, and the lack of conventional GCs, rainbow trout IgM + B cells have been shown to be stimulated by CD40L, however, whether cytokines commonly produced by T cells can further modulate this response has never been addressed to date. Thus, in this study, we determined the effects of recombinant rainbow trout adaptive cytokines interleukin 2B (IL-2B), IL-4/13A, IL-4/13B, IL-10 and IL-21 (cytokines known to activate B cells in mammals) on splenic IgM + B cells alone or in combination with CD40L. We studied how these cytokines and CD40L cooperated to promote IgM + B cell survival, proliferation and IgM secretion. The results obtained provide valuable information for the first time in teleost fish on how different T cell signals cooperate to activate B cells in the absence of GCs.

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Effects of interleukin 4 on human B-cell growth and differentiation

Cited by 7 publications

References 39 publications

A Pegylated Derivative of α-Galactosylceramide Exhibits Improved Biological Properties

A Pegylated Derivative of α-Galactosylceramide Exhibits Improved Biological Properties

Fish Cytokines and Immune Response

Distinct modes of action of CD40L and adaptive cytokines IL-2, IL-4/13, IL-10 and IL-21 on rainbow trout IgM+ B cells

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