Effects of Interleukin-4 (IL-4)-releasing microparticles and adoptive transfer of macrophages on immunomodulation and angiogenesis

Risser, Gregory E.; Machour, Majd; Hernaez-Estrada, Beatriz; Liu, Dong; Levenberg, Shulamit; Spiller, Kara L.

doi:10.1016/j.biomaterials.2023.122095

Cited by 11 publications

(8 citation statements)

References 51 publications

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“…The analysis can be affected by loss of data caused by different factors: tissue tearing, folding or washing off during mounting. Moreover, 2D sections might be misinterpreted [41,42] or the quantification performed on them might produce unreliable results (due to tissue alterations, staining variation even with a well-defined protocol or light microscope variability) [43][44][45][46]. Altogether, these elements highlight the superiority of X-ray-based 3D histology, namely, CECT and cryo-CECT, to capture the heterogeneity of complex organs such as the murine heart.…”

Section: Discussionmentioning

confidence: 99%

X-ray-Based 3D Histology of Murine Hearts Using Contrast-Enhanced Microfocus Computed Tomography (CECT) and Cryo-CECT

Pestiaux,

Marino,

Simal

et al. 2023

Hearts

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Cardiovascular diseases are the most common cause of death worldwide, and they still have dramatic consequences on the patients’ lives. Murine models are often used to study the anatomical and microstructural changes caused by the diseases. Contrast-enhanced microfocus computed tomography (CECT) is a new imaging technique for 3D histology of biological tissues. In this study, we confirmed the nondestructiveness of Hf-WD 1:2 POM-based CECT and cryogenic CECT (cryo-CECT) to image the heart in 3D. The influence of the image quality (i.e., acquisition time and spatial resolution) was assessed for the characterization of the heart structural constituents: heart integrity, the coronary blood vessels and the heart valves. Coronary blood vessels were visualized and segmented in murine hearts, allowing us to distinguish veins from arteries and to visualize the 3D spatial distribution of the right coronary artery and the left main coronary artery. Finally, to demonstrate the added value of 3D imaging, the thickness distribution of the two leaflets in the mitral valve and three cusps in the aortic valve was computed in 3D. This study corroborates the added value of CECT and cryo-CECT compared to classical 2D histology to characterize ex vivo the structural properties of murine hearts and paves the way for the detailed 3D (micro)structural analyses of future cardiovascular disease models obtained in mice and rats.

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Section: Discussionmentioning

confidence: 99%

X-ray-Based 3D Histology of Murine Hearts Using Contrast-Enhanced Microfocus Computed Tomography (CECT) and Cryo-CECT

Pestiaux,

Marino,

Simal

et al. 2023

Hearts

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“…217 It is involved in regulating the bone-immune effect, and studies have found that its regulatory effect on macrophages controls subsequent angiogenesis. 218,219 Zheng et al 220 deposited IL-4 on PEEK. The coating promotes bone regeneration by alleviating acute inflammatory responses and promoting osteogenesis, while inhibiting osteoclast generation in osteoporosis conditions.…”

Section: Biomolecular and Biofactormentioning

confidence: 99%

“…It plays an important role in regulating the balance of the T-helper (Th) cell subpopulation . It is involved in regulating the bone-immune effect, and studies have found that its regulatory effect on macrophages controls subsequent angiogenesis. , …”

Section: Surface Modification Substance Coatingsmentioning

confidence: 99%

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Multifaceted Materials for Enhanced Osteogenesis and Antimicrobial Properties on Bioplastic Polyetheretherketone Surfaces: A Review

Bai,

Zhao,

Cui

et al. 2024

ACS Omega

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Implant-associated infections and the increasing number of bone implants loosening and falling off after implantation have become urgent global challenges, hence the need for intelligent alternative solutions to combat implant loosening and falling off. The application of polyetheretherketone (PEEK) in biomedical and medical therapy has aroused great interest, especially because its elastic modulus close to bone provides an effective alternative to titanium implants, thereby preventing the possibility of bone implants loosening and falling off due to the mismatch of elastic modulus. In this Review, we provide a comprehensive overview of recent advances in surface modifications to prevent bone binding deficiency and bacterial infection after implantation of bone implants, starting with inorganics for surface modification, followed by organics that can effectively promote bone integration and antimicrobial action. In addition, surface modifications derived from cells and related products of biological activity have been proposed, and there is increasing evidence of clinical potential. Finally, the advantages and future challenges of surface strategies against medical associated poor osseointegration and infection are discussed, with promising prospects for developing novel osseointegration and antimicrobial PEEK materials.

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“…Therefore, various cytokines have shown antiosteoclastogenic properties and have been used in various research projects. 151 Risser et al 152 designed biomaterials with the release of IL-4 to control immune cell responses.…”

Section: Osteoimmunomodulation By Delivering Cytokines and Bioactive ...mentioning

confidence: 99%

Osteoinduction and osteoimmunology: Emerging concepts

Miron,

Bohner,

Zhang

et al. 2023

Periodontology 2000

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The recognition and importance of immune cells during bone regeneration, including around bone biomaterials, has led to the development of an entire field termed “osteoimmunology,” which focuses on the connection and interplay between the skeletal system and immune cells. Most studies have focused on the “osteogenic” capacity of various types of bone biomaterials, and much less focus has been placed on immune cells despite being the first cell type in contact with implantable devices. Thus, the amount of literature generated to date on this topic makes it challenging to extract needed information. This review article serves as a guide highlighting advancements made in the field of osteoimmunology emphasizing the role of the osteoimmunomodulatory properties of biomaterials and their impact on osteoinduction. First, the various immune cell types involved in bone biomaterial integration are discussed, including the prominent role of osteal macrophages (OsteoMacs) during bone regeneration. Thereafter, key biomaterial properties, including topography, wettability, surface charge, and adsorption of cytokines, growth factors, ions, and other bioactive molecules, are discussed in terms of their impact on immune responses. These findings highlight and recognize the importance of the immune system and osteoimmunology, leading to a shift in the traditional models used to understand and evaluate biomaterials for bone regeneration.

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Effects of Interleukin-4 (IL-4)-releasing microparticles and adoptive transfer of macrophages on immunomodulation and angiogenesis

Cited by 11 publications

References 51 publications

X-ray-Based 3D Histology of Murine Hearts Using Contrast-Enhanced Microfocus Computed Tomography (CECT) and Cryo-CECT

X-ray-Based 3D Histology of Murine Hearts Using Contrast-Enhanced Microfocus Computed Tomography (CECT) and Cryo-CECT

Multifaceted Materials for Enhanced Osteogenesis and Antimicrobial Properties on Bioplastic Polyetheretherketone Surfaces: A Review

Osteoinduction and osteoimmunology: Emerging concepts

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