Effects of interleukin-1 and arachiodonate on the preoptic and anterior hypothalamic neurons

Hori, Tetsuro; Shibata, Masaaki; Nakashima, Toshihiro; Yamasaki, Mari; Asami, Akihiko; Asami, Toyoko; Koga, Hisao

doi:10.1016/0361-9230(88)90010-x

Cited by 115 publications

(29 citation statements)

References 21 publications

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“…These effects may be mediated by the fast activation of the Nsphingomyelinase (N-Smase) and ceramide production (Mathias and Kolesnick, 1993;Nalivaeva et al, 2000). They are PGE2 independent and rapidly change the firing rates of neurons following binding of IL-1β to its receptor (Hori et al, 1988;Sanchez-Alavez et al, 2006;Wilkinson et al, 1993). Although the signaling molecules involved in the action of IL-1β upon defensive rage have not been identified, the observation that the maximum effect was observed at 60 minutes post injection suggests that the cyclooxygenase and PGE2 mediated pathway may be involved in IL-1β mediated potentiation of defensive rage in the cat.…”

Section: Discussionmentioning

confidence: 99%

Role of IL-1β and 5-HT2 receptors in midbrain periaqueductal gray (PAG) in potentiating defensive rage behavior in cat

Bhatt

Zalcman

et al. 2008

Brain, Behavior, and Immunity

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Feline defensive rage, a form of aggressive behavior that occurs in response to a threat can be elicited by electrical stimulation of the medial hypothalamus or midbrain periaqueductal gray (PAG). Our laboratory has recently begun a systematic examination of the role of cytokines in the regulation of rage and aggressive behavior. It was shown that the cytokine, interleukin-2 (IL-2), differentially modulates defensive rage when microinjected into the medial hypothalamus and PAG by acting through separate neurotransmitter systems. The present study sought to determine whether a similar relationship exists with respect to interleukin 1-β (IL-1β), whose receptor activation in the medial hypothalamus potentiates defensive rage. Thus, the present study identified the effects of administration of IL-1β into the PAG upon defensive rage elicited from the medial hypothalamus. Microinjections of IL-1β into the dorsal PAG significantly facilitated defensive rage behavior elicited from the medial hypothalamus in a dose and time dependent manner. In addition, the facilitative effects of IL-1β were blocked by pre-treatment with anti-IL-1β receptor antibody, while IL-1β administration into the PAG had no effect upon predatory attack elicited from the lateral hypothalamus. The findings further demonstrated that IL-1β's effects were mediated through 5-HT 2 receptors since pretreatment with a 5-HT 2C receptor antagonist blocked the facilitating effects of IL-1β. An extensive pattern of labeling of IL-1β and 5-HT 2C in the dorsal PAG supported these findings. The present study demonstrates that IL-1β in the dorsal PAG, similar to the medial hypothalamus, potentiates defensive rage behavior and is mediated through a 5-HT 2C receptor mechanism.

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Section: Discussionmentioning

confidence: 99%

Role of IL-1β and 5-HT2 receptors in midbrain periaqueductal gray (PAG) in potentiating defensive rage behavior in cat

Bhatt

Zalcman

et al. 2008

Brain, Behavior, and Immunity

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“…However, the brain site which senses blood-borne EPs/ IL-1 and the type of cells which are responsible for the release of PGE2 in response to EPs/IL-1 have not yet been determined. The hypothalamus, particularly the preoptic area (POA), has long been proposed as the primary site of action of EPs/IL-1 (Hori, Shibata, Nakashima, Yamasaki, Asami, Asami & Koga, 1988). However, the lack of evidence showing the actual entry of blood-borne EPs/IL-1 into the brain (Dinarello, Weiner & Wolff, 1978) and the lack of a consistent relationship between the thermosensitivity and the PGE2 responsiveness of POA neurones (Stitt & Hardy, 1975;Boulant & Scott, 1986) do not support this, although EPs/IL-1, which is synthesized in the brain, might contribute, at least partly, to the development of fever (Fontana, Weber & Dayer, 1984;Hori et al 1988; Nakashima, Hori, Mori, Kuriyama & Mizuno, 1989).…”

Section: Itmentioning

confidence: 99%

Thermal and PGE2 sensitivity of the organum vasculosum lamina terminalis region and preoptic area in rat brain slices.

Matsuda

Hori

Nakashima

1992

The Journal of Physiology

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SUMMARY1. The effects of local applications of prostaglandin E2 (PGE2) on the unit activity of fifty-one neurones in the organum vasculosum lamina terminalis (OVLT) region and fifty-eight neurones in the preoptic area (POA) were investigated in small tissue slices from the rat hypothalamus containing the OVLT and POA isolated from each other.2. Of these, thirty OVLT and twenty-eight POA neurones were warm sensitive and increased their discharge rate in response to a rise in tissue temperature. One OVLT neurone and one POA neurone were cold sensitive and showed the opposite type of responses to changes in temperature. The thermosensitivity of these neurones was still observed in a Ca21 free-high Mg2+ solution.3. Perfusion with PGE2 in doses between 1 and 250 nm changed the discharge rate in forty-two of fifty-one OVLT neurones and in thirty-two of fifty-eight POA neurones in a dose-dependent manner. The responses to PGE2 were not lost during synaptic blockade. The threshold dose of PGE2 to alter the discharge rate of the OVLT neurones (4-8+1-1 (S.E.M.) nM, n = 16) was significantly lower than that of the POA neurones (40 9 + 12 2 nm, n = 16).4. Fifteen of forty-two OVLT neurones exhibited the responses with a slower onset (latency 5-13 min) and a longer duration (20 min to 3 h), but such responses were observed in only one of thirty-two POA neurones.5. The responses of OVLT and POA neurones to PGE2 (50-250 nm) were reversibly blocked by a concurrent application of AH6809. a prostanoid EP, and/or a DP receptor antagonist.6. While there was no clear correlation between the type of thermosensitivity and the type of response to PGE2 among the POA neurones, a significantly higher incidence of inhibitory response to PGE2 was found among the warm-sensitive neurones in the OVLT region.7. The lower threshold responses to PGE2 and the higher incidence of PGE2 responsiveness among OVLT neurones are consistent with previous findings which showed that the highest density of PGE2 receptor binding and the highest pyrogenic sensitivity to microinjected PGE2 were observed in the OVLT region. The results MS 9526

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“…For example, electrophoretically applied rhIL-1 decreased the activity of warm-sensitive neurons in the rat hypothalamus (Hori et al, 1988). Furthermore, electrophoretically applied rhTNF and rhIL-1 suppress the activity of glucose-sensitive neurons in the art lateral hypothalamic area and increase neuronal activity of glucoreceptor neurons in the rat ventromedial hypothalamic nucleus (Oomura, 1988).…”

Section: Discussionmentioning

confidence: 98%

“…On the other hand, GABA is thought to be the predominant inhibitory transmitter in the brain and at most of its receptor sites elicits an increase in the membrane permeability to C1-as it does in bullfrog dorsal root ganglion and in Aplysia ganglia (Yarowsky and Carpenter, 1978;Hattori et al, 1983;Matsumoto et al, 1986;Oyama et al, 1990). Attention has focused on the influences of immune mediators (including the cytokines, IL-1, IL-2) on the firing rate of neurons in the central nervous system (CNS) of vertebrates (Hori et al, 1988;Oomura, 1988;Nistico and De Sarro, 1991). Cytokines may modulate the firing rate of CNS neurons by influencing membrane receptors.…”

Section: Introductionmentioning

confidence: 98%

Interleukin‐2 inhibits the GABA‐induced Cl^‐ current in identified Aplysia neurons

Sawada

Hara

Ichinose

1992

J of Neuroscience Research

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The effects of extracellularly applied recombinant human interleukin-2 (rhIL-2) on the gamma-aminobutyric acid (GABA)-induced Cl- current recorded from identified neurons (R9 and R12) of Aplysia kurodai were investigated with conventional voltage-clamp and pressure ejection techniques. Bath-applied rhIL-2 (10-40 U/ml) reduced the GABA-induced current in the neurons without affecting resting membrane conductance and the holding current. The suppressing effect of rhIL-2 on the current was completely reversible. Heat-inactivated rhIL-2 was without effect. These results suggest that the immunomodulator IL-2 can modulate the GABA-induced response in the nervous system.

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Effects of interleukin-1 and arachiodonate on the preoptic and anterior hypothalamic neurons

Cited by 115 publications

References 21 publications

Role of IL-1β and 5-HT2 receptors in midbrain periaqueductal gray (PAG) in potentiating defensive rage behavior in cat

Role of IL-1β and 5-HT2 receptors in midbrain periaqueductal gray (PAG) in potentiating defensive rage behavior in cat

Thermal and PGE2 sensitivity of the organum vasculosum lamina terminalis region and preoptic area in rat brain slices.

Interleukin‐2 inhibits the GABA‐induced Cl^‐ current in identified Aplysia neurons

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Effects of interleukin-1 and arachiodonate on the preoptic and anterior hypothalamic neurons

Cited by 115 publications

References 21 publications

Role of IL-1β and 5-HT2 receptors in midbrain periaqueductal gray (PAG) in potentiating defensive rage behavior in cat

Role of IL-1β and 5-HT2 receptors in midbrain periaqueductal gray (PAG) in potentiating defensive rage behavior in cat

Thermal and PGE2 sensitivity of the organum vasculosum lamina terminalis region and preoptic area in rat brain slices.

Interleukin‐2 inhibits the GABA‐induced Cl‐ current in identified Aplysia neurons

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Interleukin‐2 inhibits the GABA‐induced Cl^‐ current in identified Aplysia neurons