Effects of intensive lipid-lowering therapy on coronary plaques composition in patients with acute myocardial infarction: Assessment with serial coronary CT angiography

Auscher, Søren; Heinsen, Laurits Juhl; Nieman, Koen; Vinther, Kristina Høeg; Løgstrup, Brian Bridal; Møller, Jacob Eifer; Broersen, Alexander; Kitslaar, Pieter H.; Lambrechtsen, Jess; Egstrup, Kenneth

doi:10.1016/j.atherosclerosis.2015.06.007

Cited by 57 publications

(32 citation statements)

References 50 publications

(31 reference statements)

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“…The authors also found small, but significant, decrease in necrotic core volume with high-intensity statins. Collectively, these two serial IVUS studies suggested that statins increase the calcium content of coronary atherosclerotic plaque.In the current issue of Atherosclerosis, Auschler et al reported the results of serial coronary computed tomography angiography (CTA) imaging in 96 patients after acute myocardial infarction [9]. This is an interesting and innovative study that complements the previous reports that employed invasive imaging with IVUS.…”

mentioning

confidence: 81%

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Statins and the coronary plaque calcium “paradox”: Insights from non-invasive and invasive imaging

Ferencik

Chatzizisis

2015

Atherosclerosis

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mentioning

confidence: 81%

“…In the current issue of Atherosclerosis, Auschler et al reported the results of serial coronary computed tomography angiography (CTA) imaging in 96 patients after acute myocardial infarction [9]. This is an interesting and innovative study that complements the previous reports that employed invasive imaging with IVUS.…”

mentioning

confidence: 81%

Statins and the coronary plaque calcium “paradox”: Insights from non-invasive and invasive imaging

Ferencik

Chatzizisis

2015

Atherosclerosis

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“…The software has been validated against IVUS [Park et al, 2015], and was used extensively in clinical studies [Rodriguez et al, 2015; Papadopoulou et al, 2012; Ferencik et al, 2015; Auscher et al, 2015]. …”

Section: Methodsmentioning

confidence: 99%

Coronary Plaque Progression and Regression in Asymptomatic African American Chronic Cocaine Users With Obstructive Coronary Stenoses: A Preliminary Study

Sandfort

Bluemke

Vargas

et al. 2017

Journal of Addiction Medicine

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Objective Although rapid progression of coronary atherosclerosis was observed in chronic cocaine users, it is unknown whether reduced cocaine use retards the progression of atherosclerosis. We investigated whether reduced cocaine use over a 12-month period was associated coronary plaque regression in cocaine users. Methods Fifteen African American chronic cocaine users with previously coronary CT angiography (CCTA) - confirmed >50% coronary stenosis in Baltimore, Maryland, were enrolled in a study to investigate whether reduced cocaine use is associated with changes in coronary plaque burden over a 12-month period of cash-based incentive intervention, which was implemented to systematically reinforce cocaine abstinence. In addition to previous CCTA (pre-intervention), CCTA was performed at the intervention baseline and post-intervention. Plaque analyses were performed to determine (1) the trajectory of plaque changes in the absence of intervention by comparing the pre-intervention to the intervention baseline studies, and (2) the trajectory of plaque changes associated with the intervention by comparing the intervention baseline to the post-intervention studies, and (3) whether reduced cocaine use was independently associated with changes in coronary plaque burden. Results During the 12-month cash-based incentive intervention period, cocaine use in participants was lower. The medians of noncalcified plaque indices were 37.8(IQR:29.3–44.0),43.1(IQR:38.3–49.0), and 38.7(IQR:31.2–46.8) mm2 at pre-intervention, intervention baseline and post-intervention, respectively. Multivariable generalized estimating equation analysis showed that (1) both total plaque and noncalcified plaque indices at pre-intervention were significantly lowered as compared with intervention baseline levels, (2) both total plaque and noncalcified plaque indices after intervention were significantly lowered as compared with intervention baseline levels, and (3) reduced cocaine use was independently associated with lower total plaque volume index (P<0.0001) and noncalcified plaque volume index (P=0.010). Conclusions Our findings suggest that continued cocaine use may be associated with noncalcified plaque progression while reduced cocaine use may be associated with noncalcified plaque regression. Larger studies are needed to confirm these findings.

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“…A female adult, usually the wife, accompanying to the patient in consultation, is always significant and deserves the attention of the doctor. So, it needs a gender oriented practice in relation to patient's companion (37)(38)(39)(40)(41)(42)(43)(44)(45)(46)(47).…”

Section: Discussionmentioning

confidence: 99%

The social and health gender differences in patients companion in the family medicine consultation

Turabián¹,

Minier-Rodriguez²,

Moreno-Ruiz³

et al. 2017

Curr Res Integr Med

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A ll over the world women are the predominant providers of informal care for family members with chronic medical conditions or disabilities, including the elderly and adults with mental illnesses. It has been suggested that there are several societal and cultural demands on women to adopt the role of a family-caregiver (1). So, spouses often serve as the primary caregivers to their ill or disabled partners (2).The domain of health includes the entire range of issues which touch on illness, sickness, disease, wellness, as well as those activities of preventing, diagnosing, healing, caring and curing. Thus, questions about women's participation in this domain profound and immediate concern to women, and involve roles and selves. Women have domestic activities which sustain, literally and symbolically, the way of life. As the providers of health, women are responsible for securing the domestic conditions necessary for the maintenance of health and for recovery from sickness. Women also serve as mediators of outside services. Their responsibilities with the domestic health service unavoidably bring them into contact with professional health service, among them the family doctor (3).In practice, a third person (companion) frequently accompanies a patient during medical encounter. There is a high prevalence of the presence of a companion, who is in almost one of every 4 visits served in Family Medicine. Companions of the patients in the medical office are usually family members in near 100% of cases (4-9).The major results of existing studies suggest that the regular presences of companions of the patients in consultations are often perceived as helpful. Accompaniment to medical visits is associated with better self-care maintenance and management, and this effect may be mediated through satisfaction with provider communication (10). Also, companions provide company, emotional support, and they have a role in mobility and decision making of the patients (11,12). However, their participation often poses challenges (13).Despite all the above, the reports, reviews or investigations about the gender OBJECTIVES:The purpose of this study is to describe gender differences in patient's companion, and their characteristics, in family medicine consultations. METHODS:A descriptive and prospective study in a family medicine office (Toledo, Spain) was carried out. For each patient and companion, the following variables were collected: age, gender, chronic illness, chief complaint, medications taken, social class, request for additional tests, kinship, social status and availability of companion. The bivariate comparisons were performed using the test of Chi squared, the Student t test, and the MannWhitney test.RESULTS: 104 companions to the patient in the family medicine office were obtained. Of these, 65 (62.5%) were female, and 39 (37.5%) male.In the female companions with regard to the male companions: there were 69% in the group of 40-64 years old vs. 49% (p = 0.02); were wife (34%) vs. husband (56%) (P=0.001); were unskilled...

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Effects of intensive lipid-lowering therapy on coronary plaques composition in patients with acute myocardial infarction: Assessment with serial coronary CT angiography

Cited by 57 publications

References 50 publications

Statins and the coronary plaque calcium “paradox”: Insights from non-invasive and invasive imaging

Statins and the coronary plaque calcium “paradox”: Insights from non-invasive and invasive imaging

Coronary Plaque Progression and Regression in Asymptomatic African American Chronic Cocaine Users With Obstructive Coronary Stenoses: A Preliminary Study

The social and health gender differences in patients companion in the family medicine consultation

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