Effects of insecticide resistance and exposure on Plasmodium development in Anopheles mosquitoes

Minetti, Corrado; Ingham, Victoria A.; Ranson, Hilary

doi:10.1016/j.cois.2019.12.001

Cited by 36 publications

(35 citation statements)

References 59 publications

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“…populations to deltamethrin LLINs did not induce any delayed mortality [47]. To date there is a paucity of data regarding the interactions between insecticide resistance and Plasmodium development [48]. In this study, An.…”

Section: Malaria Prevalencementioning

confidence: 69%

Reduced long-lasting insecticidal net efficacy and pyrethroid insecticide resistance are associated with over-expression ofCYP6P4, CYP6P3andCYP6Z1in populations ofAnopheles coluzziifrom South-East Côte d’Ivoire

Meiwald

Clark

Kristan

et al. 2020

Preprint

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BackgroundResistance to major public health insecticides in Côte d’Ivoire has intensified and now threatens the long-term effectiveness of malaria vector control interventions.MethodsThis study evaluated the bioefficacy of conventional and next-generation long-lasting insecticidal nets (LLINs), determined resistance profiles, and characterized molecular and metabolic mechanisms in wild Anopheles coluzzii from South-East Côte d’Ivoire in 2019.ResultsPhenotypic resistance was intense: more than 25% of mosquitoes survived exposure to ten times the doses of pyrethroids required to kill susceptible populations. Similarly, 24-hour mortality to deltamethrin-only LLINs was very low and not significantly different to an untreated net. Sub-lethal pyrethroid exposure did not induce significant delayed vector mortality 72 hours later. In contrast, LLINs containing the synergist piperonyl butoxide (PBO), or new insecticides, clothianidin and chlorfenapyr, were highly toxic to An. coluzzii. Pyrethroid-susceptible An. coluzzii were significantly more likely to be infected with malaria, compared to those that survived insecticidal exposure. Pyrethroid resistance was associated with significant over-expression of CYP6P4, CPY6Z1 and CYP6P3.ConclusionsStudy findings raise concerns regarding the operational failure of standard LLINs and support the urgent deployment of vector control interventions incorporating PBO, chlorfenapyr or clothianidin in areas of high resistance intensity in Côte d’Ivoire.

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Section: Malaria Prevalencementioning

confidence: 69%

Reduced long-lasting insecticidal net efficacy and pyrethroid insecticide resistance are associated with over-expression ofCYP6P4, CYP6P3andCYP6Z1in populations ofAnopheles coluzziifrom South-East Côte d’Ivoire

Meiwald

Clark

Kristan

et al. 2020

Preprint

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“…It is important to remark that changes in Anopheles vector competence for malaria parasites have been linked to insecticide resistance status. In fact, insecticide exposure is detrimental for Plasmodium in the midgut lumen and is more than likely that additional resistance mechanisms impact parasite development within the vector host (25). It is worth to mention that there are already several examples of insect symbionts that contribute in whole or in part to the lower resistance of the host to the insecticide.…”

Section: Resultsmentioning

confidence: 99%

Phylogenomics reveals thatAsaiasymbionts from insects underwent convergent genome reduction, preserving an insecticide-degrading gene

Comandatore¹,

Damiani

Cappelli

et al. 2020

Preprint

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The mosquito microbiota is composed by several lineages of microorganisms whose ecological roles and evolutionary histories have yet to be investigated in depth. Among these microorganisms, Asaia bacteria play a prominent role, given its abundance in the gut, reproductive organs and salivary glands of different mosquito species, while its presence has also been reported in several other insects. Notably, Asaia has great potential as a tool for the control of mosquito-borne diseases. Here, we present a wide phylogenomic analysis of Asaia strains isolated from different species of mosquito vectors and from different populations of the Mediterranean fruit fly (medfly) Ceratitis capitata, an insect pest of worldwide economic importance. We show that phylogenetically distant lineages of Asaia experienced independent genome reductions, despite following a common pattern, characterized by the early loss of genes involved in genome stability. This result highlights the role of specific metabolic pathways in the symbiotic relationship between Asaia and the insect host. Finally, we discovered that all but one of the Asaia strains included in the study possess the pyrethroid hydrolase gene. Phylogenetic analysis revealed that this gene is ancestral in Asaia, strongly suggesting that it played a role in the establishment of the symbiotic association between these bacteria and the mosquito hosts.

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“…While the obtained results were contradictory, their study suggested that L119F GSTE2 may impact vector competence by increasing parasite load. A review on the effect of insecticide resistance on Plasmodium development has recently been published [98]. Further studies are required to fully establish the impact of metabolic resistance on vector competence in mosquitoes.…”

Section: Metabolic Resistancementioning

confidence: 99%

Anopheles metabolic proteins in malaria transmission, prevention and control: a review

et al. 2020

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The increasing resistance to currently available insecticides in the malaria vector, Anopheles mosquitoes, hampers their use as an effective vector control strategy for the prevention of malaria transmission. Therefore, there is need for new insecticides and/or alternative vector control strategies, the development of which relies on the identification of possible targets in Anopheles. Some known and promising targets for the prevention or control of malaria transmission exist among Anopheles metabolic proteins. This review aims to elucidate the current and potential contribution of Anopheles metabolic proteins to malaria transmission and control. Highlighted are the roles of metabolic proteins as insecticide targets, in blood digestion and immune response as well as their contribution to insecticide resistance and Plasmodium parasite development. Furthermore, strategies by which these metabolic proteins can be utilized for vector control are described. Inhibitors of Anopheles metabolic proteins that are designed based on target specificity can yield insecticides with no significant toxicity to non-target species. These metabolic modulators combined with each other or with synergists, sterilants, and transmission-blocking agents in a single product, can yield potent malaria intervention strategies. These combinations can provide multiple means of controlling the vector. Also, they can help to slow down the development of insecticide resistance. Moreover, some metabolic proteins can be modulated for mosquito population replacement or suppression strategies, which will significantly help to curb malaria transmission.

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Effects of insecticide resistance and exposure on Plasmodium development in Anopheles mosquitoes

Cited by 36 publications

References 59 publications

Reduced long-lasting insecticidal net efficacy and pyrethroid insecticide resistance are associated with over-expression ofCYP6P4, CYP6P3andCYP6Z1in populations ofAnopheles coluzziifrom South-East Côte d’Ivoire

Reduced long-lasting insecticidal net efficacy and pyrethroid insecticide resistance are associated with over-expression ofCYP6P4, CYP6P3andCYP6Z1in populations ofAnopheles coluzziifrom South-East Côte d’Ivoire

Phylogenomics reveals thatAsaiasymbionts from insects underwent convergent genome reduction, preserving an insecticide-degrading gene

Anopheles metabolic proteins in malaria transmission, prevention and control: a review

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