Effects of inorganic nitrate and beetroot supplementation on endothelial function: a systematic review and meta-analysis

Lara, José; Ashor, Ammar W.; Oggioni, Clio; Ahluwalia, Amrita; Mathers, John C.; Siervo, Mario

doi:10.1007/s00394-015-0872-7

Cited by 124 publications

(90 citation statements)

References 35 publications

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“…In recent previous reports by our group, two systematic reviews of the literature showed that inorganic nitrate or beetroot juice consumption were associated with significant reductions in SBP (-4.4mmHg 95% CI: -5.9, -2.8; P< 0.001) [3] , and improvements in FMD (SMD 0.52; 95 % CI 0.15, 0.68; P = 0.002) [4].…”

Section: Scientific Analysis Of Findingsmentioning

confidence: 74%

“…Recent systematic reviews of the literature indicate that supplementation with dietary nitrates, or foods rich in these compounds such as beetroot, have the potential to lower blood pressure [3] and improve endothelial function [4], both regarded as early indicators of cardiovascular diseases (CVD). These benefits are valuable when developing effective nutritional strategies targeting specific key metabolic risk factors for the prevention and management of CVD.…”

Section: Introductionmentioning

confidence: 99%

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Tomato and lycopene supplementation and cardiovascular risk factors: A systematic review and meta-analysis

et al. 2017

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Section: Scientific Analysis Of Findingsmentioning

confidence: 74%

Section: Introductionmentioning

confidence: 99%

Tomato and lycopene supplementation and cardiovascular risk factors: A systematic review and meta-analysis

et al. 2017

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“…Evidence from .30, mostly small-scale randomized controlled trials have established that intake of nitrate-rich vegetables can enhance endogenous NO levels and improve measures of vascular health, including blood pressure and endothelial function (9)(10)(11)(12). There is a need to determine whether these improvements in risk factors can translate into improved long-term 4 Measured in 1215 participants.…”

Section: Discussionmentioning

confidence: 99%

“…These studies have shown that increased nitrate intake can reduce blood pressure (11) and improve endothelial function (12). It has not been determined, however, whether this action translates into a reduction in the long-term risk of ASVD.…”

Section: Introductionmentioning

confidence: 99%

Association of dietary nitrate with atherosclerotic vascular disease mortality: a prospective cohort study of older adult women

Blekkenhorst

Bondonno

Lewis

et al. 2017

The American Journal of Clinical Nutrition

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Background: Nitrate-rich vegetables lower blood pressure and improve endothelial function in humans. It is not known, however, whether increased consumption of nitrate-rich vegetables translates to a lower risk of atherosclerotic vascular disease (ASVD) mortality. Objective: The objective was to investigate the association of nitrate intake from vegetables with ASVD mortality. Design: A total of 1226 Australian women aged 70-85 y without prevalent ASVD and/or diabetes were recruited in 1998 and were studied for 15 y. We assessed demographic and ASVD risk factors at baseline (1998), and we used a validated food-frequency questionnaire to evaluate dietary intake. Nitrate intake from vegetables was calculated by use of a newly developed comprehensive database. The primary outcome was any death attributed to ASVD ascertained by using linked data that were provided via the Western Australian Data Linkage system. We used Cox proportional hazards modeling to examine the association between nitrate intake and ASVD mortality before and after adjustment for lifestyle and cardiovascular disease risk factors. Conclusions: Nitrate intake from vegetables was inversely associated with ASVD mortality independent of lifestyle and cardiovascular disease risk factors in this population of older adult women without prevalent ASVD or diabetes. These results support the concept that nitrate-rich vegetables may reduce the risk of age-related ASVD mortality. This trial was registered at www. anzctr.org.au as ACTRN12617000640303.

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“…Recently, 4-week supplementation with sodium nitrate resulted in improved endothelial dysfunction when assessed by brachial artery flow mediated vasodilation and also reduce arterial stiffness in an elderly population [12]. A beneficial effect of inorganic nitrate or beetroot supplementation on endothelial function was reported by a recent meta-analysis [13]. Another recent meta-analysis (total number of participants n = 254; 7-30 participants per study) suggests that a dose of 300-600 mg of sodium nitrate modestly reduces blood pressure [14].…”

Section: Aimmentioning

confidence: 97%

A Randomized double-blind placebo-controlled Crossover Trial of Sodium Nitrate in Patients With Stable Angina INAS

Schwarz¹,

Singh²,

Parasuraman³

et al. 2016

Future Cardiol.

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In an aging western population, a significant number of patients continue to suffer from angina once all revascularization and optimal medical treatment options are exhausted. Under experimental conditions, oral supplementation with inorganic nitrate was shown to exhibit a blood pressure-lowering effect, and has also been shown to promote angiogenesis, improve endothelial dysfunction and mitochondrial efficiency in skeletal muscle. It is unknown whether similar changes occur in cardiac muscle. In the current study, we investigate whether oral sodium nitrate treatment will improve myocardial ischemia in patients with stable angina.

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Effects of inorganic nitrate and beetroot supplementation on endothelial function: a systematic review and meta-analysis

Abstract: Inorganic nitrate and beetroot supplementation was associated with beneficial effects on EF. These effects appear to be reduced in older subjects and in subjects with greater cardiometabolic risk.

Cited by 124 publications

References 35 publications

Tomato and lycopene supplementation and cardiovascular risk factors: A systematic review and meta-analysis

Tomato and lycopene supplementation and cardiovascular risk factors: A systematic review and meta-analysis

Association of dietary nitrate with atherosclerotic vascular disease mortality: a prospective cohort study of older adult women

A Randomized double-blind placebo-controlled Crossover Trial of Sodium Nitrate in Patients With Stable Angina INAS

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