Effects of inorganic copper injection in beef cows at late gestation on fetal and postnatal growth, hematology and immune function of their progeny

Rodríguez, A. M.; Valiente, Sebastián López; Mattioli, Guillermo Alberto; Maresca, Sebastian

doi:10.1016/j.rvsc.2021.06.017

Cited by 7 publications

(8 citation statements)

References 37 publications

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“…The appropriate concentration of essential mineral elements enables the normal development of their physiological, catalytic, and regulatory functions ( 39 ). Although many researches indicated plasma samples were more suitable for measuring concentrations of mineral Ca, P, S, and Cu, there were many studies using serum samples to detected these mineral elements and established ranges of the standard concentration for sheep ( 15 , 40–43 ). To uniform this study, the serum samples were used to measure both the concentration of the mineral elements and the biochemical parameters.…”

Section: Discussionmentioning

confidence: 99%

“…Cu is widely found in various enzymes and cofactors, especially in the liver ( 13 , 14 ). In some research, it is revealed that copper deficiency causes reproductive disorders and alters the immune response of ruminants ( 15 ). A persistently low concentration of Cu in the serum of sheep can lead to an increase in the risk of mortality ( 16 ).…”

Section: Introductionmentioning

confidence: 99%

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Effects of essential mineral elements deficiency and supplementation on serum mineral elements concentration and biochemical parameters in grazing Mongolian sheep

Jin

Zhang

et al. 2023

Front. Vet. Sci.

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Traditional sheep grazing is the pillar industry and the main source of income for local herders in the Inner Mongolia Autonomous Region of China. However, grazing sheep often suffer from mineral deficiency. In the present study, the feeding experiment was performed on 84 grazing Wu Ranke sheep. After being divided into calcium (Ca), zinc (Zn), copper (Cu), cobalt (Co), manganese (Mn), and selenium (Se) treatment groups, they were fed with a mineral deficient diet for 60 days and then a mineral supplement diet for 41 days. Serum samples were collected three times, 10 concentrations of essential mineral elements and 15 concentrations/activity of biochemical parameters were measured to assess the effects of mineral deficiency and supplementation on the physical health of sheep. The results revealed that the sheep showed mineral Ca, Cu, Co, Mn, and Se deficiencies after feeding their respective mineral deficient diet. Deficiency in dietary Ca, Zn, Cu, Co, Mn, and Se may adversely affect the liver, myocardium and pancreas of sheep. The prompt supplementation of dietary Zn, Cu, Co, Mn, and Se may alleviate the damage caused to the liver, myocardium and pancreas, while that of dietary Ca improved energy generation. In conclusion, the adequate supplementation of dietary Ca, Zn, Cu, Co, Mn, and Se is essential for avoiding the impairment caused to the liver, myocardium and pancreas function of sheep by the deficiency in essential dietary minerals.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Effects of essential mineral elements deficiency and supplementation on serum mineral elements concentration and biochemical parameters in grazing Mongolian sheep

Jin

Zhang

et al. 2023

Front. Vet. Sci.

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“…Cu deficiency occurs more frequently in ruminants than in monogastric mammals because redox reactions in the rumen lead to thiomolybdate formation from sulfide and molybdate, which in turn generates insoluble material with Cu in digestive juices, thus significantly reducing the efficiency of Cu uptake by ruminants [ 7 ]. Inadequate intake of Cu will lead to reproductive disorders and reduced fertility in animals, as well as reduced concentration of norepinephrine in the brains of rats and sheep [ 6 , 8 ]. Further research has indicated that an extended deficiency of Cu in sheep can greatly elevate their mortality rate [ 9 ].…”

Section: Introductionmentioning

confidence: 99%

Transcriptomics and metabolomics analysis reveal the dietary copper deficiency and supplementation effects of liver gene expression and metabolite change in grazing sheep

Jin,

Meng,

et al. 2024

BMC Genomics

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Background The appropriate mineral nutrients are essential for sheep growth and reproduction. However, traditional grazing sheep often experience mineral nutrient deficiencies, especially copper (Cu), due to inadequate mineral nutrients from natural pastures. Results The results indicated that dietary Cu deficiency and supplementation significantly reduced and elevated liver concentration of Cu, respectively (p < 0.05). FOXO3, PLIN1, ACTN2, and GHRHR were identified as critical genes using the weighted gene co-expression network analysis (WGCNA), quantitative real-time polymerase chain reaction (qRT-PCR), and receiver operating characteristic curve (ROC) validation as potential biomarkers for evaluating Cu status in grazing sheep. Combining these critical genes with gene functional enrichment analysis, it was observed that dietary Cu deficiency may impair liver regeneration and compromise ribosomal function. Conversely, dietary Cu supplementation may enhance ribosomal function, promote lipid accumulation, and stimulate growth and metabolism in grazing sheep. Metabolomics analysis indicated that dietary Cu deficiency significantly decreased the abundance of metabolites such as cholic acid (p < 0.05). On the other hand, dietary Cu supplementation significantly increased the abundance of metabolites such as palmitic acid (p < 0.05). Integrative analysis of the transcriptome and metabolome revealed that dietary Cu deficiency may reduce liver lipid metabolism while Cu supplementation may elevate it in grazing sheep. Conclusions The Cu content in diets may have an impact on hepatic lipid metabolism in grazing sheep. These findings provide new insights into the consequences of dietary Cu deficiency and supplementation on sheep liver and can provide valuable guidance for herders to rationalize the use of mineral supplements.

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“…As the best pure metal, Cu is extremely hard, wear‐resistant, with good ductility, thermal conductivity, and electrical conductivity. Cu is a crucial micronutrient for human health since it plays an important role in the growth and maintenance of central nervous system, blood, brain, liver, skin, hair, bone tissues, as well as other internal organs 1–3 . The amount of Cu is approximately 100–150 mg in the human body.…”

Section: Introductionmentioning

confidence: 99%

“…liver, skin, hair, bone tissues, as well as other internal organs. [1][2][3] The amount of Cu is approximately 100-150 mg in the human body. It participates in the assembly of various enzymes, such as superoxide dismutase 1 (SOD1) and cyclooxygenase (COX).…”

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confidence: 99%

Nanotechnology connecting copper metabolism and tumor therapy

Dong

Zhou

2023

MedComm – Biomaterials and Applications

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Copper (Cu) is an essential trace element in the human body that is involved in the formation of several natural enzymes, such as superoxide dismutase and cyclooxygenase. Due to the high density of the outer electron cloud of Cu, which allows the transfer of multiple electrons, Cu is often used as the catalytic center in various metabolic enzymes. However, both deficiency and excessive accumulation of Cu can result in irreversible damage to cells. Therefore, strategies to regulate Cu metabolism, such as Cu exhaustion and Cu supplementation, have emerged as attractive approaches in anticancer therapy, due to the potential damages caused by Cu metabolism disorders. Notably, recent advancements in nanotechnology have enabled the development of nanomaterials that can regulate Cu metabolism, making this therapy applicable in vivo. In this review, we provide a systematic discussion of the physical and chemical properties of Cu and summarize the applications of nanotechnology in Cu metabolism‐based antitumor therapy. Finally, we outline the future directions and challenges of nano‐Cu therapy, emphasizing the scientific problems and technical bottlenecks that need to be addressed for successful clinical translation.

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Effects of inorganic copper injection in beef cows at late gestation on fetal and postnatal growth, hematology and immune function of their progeny

Cited by 7 publications

References 37 publications

Effects of essential mineral elements deficiency and supplementation on serum mineral elements concentration and biochemical parameters in grazing Mongolian sheep

Effects of essential mineral elements deficiency and supplementation on serum mineral elements concentration and biochemical parameters in grazing Mongolian sheep

Transcriptomics and metabolomics analysis reveal the dietary copper deficiency and supplementation effects of liver gene expression and metabolite change in grazing sheep

Nanotechnology connecting copper metabolism and tumor therapy

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