Effects of injury and inflammation on pulpal and periapical nerves

Byers, Margaret R.; Taylor, Patrick E.; Khayat, Bertrand G.; Kimberly, Charles L.

doi:10.1016/s0099-2399(06)81568-2

Cited by 163 publications

(112 citation statements)

References 21 publications

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“…2 Teeth with irreversible pulpitis (IP) are perceived to be more difficult to anaesthetise than those with normal pulps because nerves arising from inflamed tissue have altered resting potentials and decreased excitability thresholds. 56,57 Studies comparing anaesthetic success of different LAs in teeth with IP have defined success as patients reporting no to mild pain on a Visual Analogue Scale (VAS) pain scale during the endodontic procedure. When used as a supplemental anaesthetic, after lignocaine did not provide profound anaesthesia during endodontic treatment in maxillary teeth, no difference in pain experience was found between articaine and lignocaine.…”

Section: Local Anaesthetic Failurementioning

confidence: 99%

Articaine: a review of the literature

Yapp¹,

Hopcraft

Parashos

2011

Br Dent J

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Section: Local Anaesthetic Failurementioning

confidence: 99%

Articaine: a review of the literature

Yapp¹,

Hopcraft

Parashos

2011

Br Dent J

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“…It is now well-accepted that the pulpal innervation is not static, but shows dynamic changes; pulpal sensory nerve fibers undergo extensive sprouting reactions in response to injury (Byers et al, 1990; reviewed by Byers, 1994). This may result in an increase in the number of potential sites of neuropeptide release and thus may amplify interactions between nerve vasculature and the immunological system of the injured pulp.…”

Section: Dense Sensory Innervationmentioning

confidence: 99%

Immune Defense Mechanisms of the Dental Pulp

Jontell

Okiji

Dahlgren

et al. 1998

Critical Reviews in Oral Biology & Medicine

204

169

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Defense reactions of the dentin/pulp complex involve a variety of biological systems, in which the immune system plays a pivotal role. The knowledge of the organization and function of pulpal immunocompetent cells has been sparse, but in recent years a significant body of information of immune mechanisms in general has provided a footing for substantial new knowledge of the immune mechanisms of the dental pulp. The identification of pulpal dendritic cells (DCs) has generated research activities which have led to a concept of how an antigenic challenge may evoke a pulpal inflammatory response. Although DCs are not able to identify foreign antigens specifically, they provide necessary signals to activate T-lymphocytes which in turn will orchestrate other immunocompetent cells to mount the local immune defense of the dental pulp. The purpose of this review is to accent the organization and function of pulpal DCs and other tissue and cellular components and to provide a basis for how they may interact to instigate pulpal defense mechanisms.

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“…Accordingly, immunohistochemistry for CGRP has been applied to investigate the neurophysiology of dental pulp, and suggested a possible role of CGRP as a vasoregulator in the dental pulp (UDDMAN et al, 1986;WAKISAKA et al, 1987). Further, dynamic responses of CGRP-immunoreactive nerve fibers to external stimuli including dentinal injury have been demonstrated, suggesting CGRP involvement in tissue repair as well as in sensory and/or vascular regulation KHAYAT et al, 1988;TAYLOR et al, 1988;BYERS et al, 1990 …”

mentioning

confidence: 99%