Effects of initiation day of clomiphene citrate on the endometrium of women with regular menstrual cycles

Triwitayakorn, Anusorn; Suwajanakorn, Somchai; Triratanachat, Surang; Sampatanukul, Pichet; Pruksananonda, Kamthorn; Sereepapong, Wisan

doi:10.1016/s0015-0282(02)03192-8

Cited by 11 publications

(4 citation statements)

References 26 publications

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“…Interestingly, a wide range of individual endometrial maturation was observed in a study including fertile women (8). In a similar study including 33 healthy women with regular menstrual cycles, one-third of the endometrial biopsies were out of phase, clearly indicating the variable duration of the secretory phase among women (9). A delayed endometrium was also detected in 47% of infertile patients and 24% of fertile patients in a study conducted by Lindhard et al (10).…”

mentioning

confidence: 89%

Endometrial Dating Method Detects Individual Maturation Sequences During the Secretory Phase

Alfer

Fattahi

Bleisinger

et al. 2020

In Vivo

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Background/Aim: This study assessed whether a new immunohistochemical dating method allows precise endometrial dating allowing optimal timing for embryo transfer. Patients and Methods: A novel method was used for endometrial dating, with parameters including menstrual cycle days, Noyes histological criteria, along with immunohistochemical expression pattern of estrogen and progesterone receptors and proliferation marker Ki-67. Endometrial maturation was analyzed on days +5 to +10 after ovulation or progesterone administration in 217 biopsies from 151 subfertile patients during the secretory phase. Results: Endometrial maturation varied individually, occurring 1.68±1.67 days late. Comparison of histological maturation with clinical days after ovulation showed a delay of about 2 days. Conclusion: Endometrial maturation requires 8 days, rather than the expected 6 days, to reach the histological mid-secretory phase. This is not a delay and is also seen in fertile patients. The new analysis method used is superior to that using Noyes criteria alone and provides a better basis for determining conditions for optimal timing of embryo transfers.

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mentioning

confidence: 89%

Endometrial Dating Method Detects Individual Maturation Sequences During the Secretory Phase

Alfer

Fattahi

Bleisinger

et al. 2020

In Vivo

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“…Triwitayakorn et al . reported that starting CC on either day 1 or day 5 of the menstrual cycle did not have any differential effects on the endometrium of women with regular menstrual cycles 20 . Dehbashi et al .…”

Section: Discussionmentioning

confidence: 97%

“…18,19 Triwitayakorn et al reported that starting CC on either day 1 or day 5 of the menstrual cycle did not have any differential effects on the endometrium of women with regular menstrual cycles. 20 Dehbashi et al reported that endometrial thickness was significantly thinner in women taking CC than in women without taking CC during the late proliferative phase but there was no significant difference during the midsecretory phase. 21 Our findings indicated that endometrial thickness is significantly decreased in the follicular phase of CC-induced cycles with initiation on day 5 compared to that with initiation on day 1.…”

Section: Discussionmentioning

confidence: 98%

Effect of repeated administration of clomiphene citrate at two different times on the endometrium in patients undergoing intrauterine insemination

Wada

Kasai

Nagai

et al. 2004

Reprod Medicine & Biology

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Clomiphene citrate (CC) has been widely used for induction of ovulation; however, despite the high rate of ovulation, the pregnancy rate is only 30%. The anti-estrogenic effect of CC on the endometrium is one explanation for this finding. It is well known that repeated administration of CC enhances its anti-estrogenic effect. To overcome this adverse affect, a number of techniques have been used. One technique is the early administration of CC, in an attempt to decrease the anti-estrogenic effects of CC on the endometrium. The aim of the present study was to retrospectively evaluate if repeated administration of CC at varying times may affect the endometrium during preovulatory period; pregnancy rates were compiled for patients with unexplained infertility undergoing intrauterine insemination (IUI). The patients were divided into four groups based on the number of repeat administrations and the time of CC administration. The endometrial thickness at the day of human chorionic gonadotropin administration was greater in early administration within three consecutive CC cycles than the others. When the endometrium is thin during classical administration of CC, it is worth attempting the early administration of CC in the CC/IUI treatment for patients with unexplained infertility. However, this effect disappeared over the duration of the three consecutive CC cycles. (Reprod Med Biol 2004; : 153-157).

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“…The effect of the timing of CC administration on endometrial thickness has been reported [20-22]. Early administration of CC (100 mg CC; day 1–5) showed higher endometrial thickness compared with the standard CC treatment (100 mg CC; day 5–9), but it was not significant [20-22]. These studies enrolled all the infertile women who showed and did not show a thin endometrium during the standard CC treatment.…”

Section: Discussionmentioning

confidence: 99%

A pilot study to prevent a thin endometrium in patients undergoing clomiphene citrate treatment

et al. 2013

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AbstractsBackgroundClomiphene citrate (CC) is most commonly used as a first-line treatment of infertility. However, a disturbance of endometrial growth by the adverse effects of the CC has been recognized. Since a thin endometrium is recognized as a critical factor of implantation failure, preventing CC-induced thinning of the endometrium is important. This study was undertaken to investigate whether the modified CC treatments are useful to prevent a thin endometrium in patients undergoing CC treatments.MethodsThis study is a prospective, randomized controlled study. The study was performed at the Saiseikai Shimonoseki General Hospital during a 4-month period (May 2012 to September 2012). Sixty-six infertile women who had a thin endometrium (< 8 mm) during the standard CC treatment (50 mg/day on days 5–9 of the menstrual cycle) were enrolled. The patients were randomly divided into three groups: 22 patients were given 25 mg/day CC on days 5–9 (half-dose group), 22 patients were given 50 mg/day CC on days 1–5 (early administration group) and 22 patients received a standard CC treatment again (control group). Endometrial thickness at the induction of ovulation was assessed by ultrasonography. The primary endpoint of this study was an endometrial thickness.ResultsHalf dose administration and early administration improved the endometrial thickness (≥ 8 mm) in 14 patients (70%) and in 19 patients (90%) respectively, while only 3 patients (15%) improved in endometrial thickness in the control group. The mean endometrial thickness was also significantly higher in the half dose group (8.6 ± 1.5 mm) and early administration group (9.4 ± 1.5 mm) compared to the control group (6.7 ± 1.8 mm). No side effect was observed in this study.ConclusionsThe modified treatment with a half-dose or early administration of CC significantly increased endometrial thickness in patients with a history of thin endometrium caused by the standard CC regimen. The modified CC treatments in this study can be beneficial for patients with a thin endometrium as a result of standard CC treatment.Trial registrationClinical Trial Registration Number: UMIN000007959.

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Effects of initiation day of clomiphene citrate on the endometrium of women with regular menstrual cycles

Cited by 11 publications

References 26 publications

Endometrial Dating Method Detects Individual Maturation Sequences During the Secretory Phase

Endometrial Dating Method Detects Individual Maturation Sequences During the Secretory Phase

Effect of repeated administration of clomiphene citrate at two different times on the endometrium in patients undergoing intrauterine insemination

A pilot study to prevent a thin endometrium in patients undergoing clomiphene citrate treatment

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