Effects of Inhaled Salbutamol on Transient Tachypnea of the Newborn

Role of Salbutamol in The Management of Transient Tachypnea of the Newborn: A Comparative Prospective Study

“…17 On the contrary, Kaur et al in India found a male predominance as 65% of their studied newborns were male. 18 In our patients, TTN scores before and 4 hours after treatment with Salbutamol were 8.30±1.37 and 2.67±0.76, respectively, with an observed mean change of 5.63±1.22. In contrast, the average TTN score before and after treatment with normal saline was 8.00±1.23 and 7.33±0.99, respectively, with a change of 0.63±1.54.…”

“…17 However, in India, Basiri et al while managing 100 newborns with TTN on nasal prong oxygen at the gestational age of 35-41 weeks, failed to identify any improvement in TTN Score before and 4 hours after Salbutamol (0.15 mg/kg) nebulization as the reported scores were 5.7 and 5.4 respectively. 18 In our study group, RR (respiratory rate) was 69.43±4.25 per minute before Salbutamol administration, with the exhibited change of 9.80±2.05 post salbutamol. In contrast, RR before and after treatment with normal saline were 68.80 ± 3.91 and 72.50 ± 3.10 per minute, respectively, with a mean deterioration of -3.73 ± 2.57.…”

“…Another study, however, documented no improvement as RR before and 4 hours post Salbutamol nebulization were 73.4 and 72.2, respectively. 18 Our study exhibited considerable improvement in the respiratory distress of neonates with nebulized salbutamol. During labor, levels of β-adrenergic agonists such as endogenous steroids and catecholamines rise with the rapid clearing of fetal lung fluid as sodium moves from the alveoli into the interstitiumthereby removing Na+1 and fluid.…”

Salbutamol and Epinephrine Inhalation as a Conservative Treatment of Transient Tachypnea of Newborn: a Pilot Randomized Controlled Trial

“…Moreover, the most recent RCTs, including 252 newborn infants, were conducted in Egypt, Pakistan, and Iran. They reported that a single dose of inhaled salbutamol was statistically signi cant in reduction of respiratory rate after the intervention 19,20,24 . Furthermore, the most recent Cochrane meta-analysis, including 498 babies (270 in salbutamol groups and 228 in control groups) agrees with our nding in relation to the duration of tachypnea, indicating that it was signi cantly less in the salbutamol group in comparison to the control group 17 .…”