Effects of inhaled corticosteroids (ICS) on lung microbiota and local immune response in long-term treatment of chronic obstructive pulmonary disease (COPD): utility of titration and therapeutic index

Toraldo, Domenico Maurizio; Rizzo, Enzo; Conte, Luana

doi:10.1007/s00210-022-02237-z

Cited by 4 publications

(3 citation statements)

References 81 publications

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“… 81 ICS could contribute to shifts in microbial composition and functional pathways, 82 as well as immune response. 83 …”

Section: Discussionmentioning

confidence: 99%

“…81 ICS could contribute to shifts in microbial composition and functional pathways, 82 as well as immune response. 83 While the short-term effect of ICS use can be controlled by exclusion criteria, the effect of long-term ICS use is unknown for asthma and largely unaccounted for in most studies.…”

Section: Allergy-associated Inhaled Corticosteroids Medication As a P...mentioning

confidence: 99%

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Association Between Adult Antibiotic Use, Microbial Dysbiosis and Atopic Conditions – A Systematic Review

Ng,

van Hasselt,

Aggarwal

et al. 2023

JAA

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Background Strong associations between early antibiotic exposure and increased risk of childhood allergies have been established. Antibiotics have the potential to induce microbial dysbiosis that may be linked to allergic conditions. This review examines the limited available evidence on the associations between adult antibiotic use, microbial dysbiosis and atopic conditions. Methods A systematic literature search was conducted using PubMed and Embase for relevant studies, published between 01–01–2000 and 08–17–2022. We searched for associations between antibiotic use, microbial dysbiosis, and allergic conditions in adults, defined as over 13 years of age for the purposes of this review. Results Twenty-one studies were analyzed, with the inclusion of four narrative reviews as scarce relevant literature was found when stricter selection criteria were employed. Relevant studies predominantly focused on asthma. Significant microbial differences were observed in most measures between healthy subjects and subjects with allergic conditions. However, no system-wise and strain-wise associations were evident. Notably, at the phyla level, the Bacillota and Pseudomonadota phyla were associated with asthmatics, while the Actinobacteria phylum was linked to healthy controls. Asthmatics tends to reflect upregulation in the Bacillota and Pseudomonadota phyla in both airway and gut microbiomes. Conclusion No compelling evidence could be found between adult antibiotic exposure, consequent microbial dysbiosis, and allergic conditions in adults. Our review is limited by scarce literature and therefore remains inconclusive. However, potential implications of antibiotic use impacting on allergic conditions justify additional research and heightened pharmacovigilance in this area.

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“… 81 ICS could contribute to shifts in microbial composition and functional pathways, 82 as well as immune response. 83 …”

Section: Discussionmentioning

confidence: 99%

Section: Allergy-associated Inhaled Corticosteroids Medication As a P...mentioning

confidence: 99%

Association Between Adult Antibiotic Use, Microbial Dysbiosis and Atopic Conditions – A Systematic Review

Ng,

van Hasselt,

Aggarwal

et al. 2023

JAA

View full text Add to dashboard Cite

show abstract

“…In addition, drug treatment can also affect the relationship between IBD and COPD. The main effects of stable COPD treatment drugs are to relax the bronchi, inhibit the secretion of in ammatory media in the body (27,28), reduce sputum secretion, and improve the patient's cough, expectoration, and other related symptoms (29,30). Therefore, it maybe has little effect on IBD in ammation.…”

Section: Discussionmentioning

confidence: 99%

Inflammatory bowel disease has a negative causal effect on chronic obstructive pulmonary disease: A two-sample bidirectional mendelian randomization study

Yang

Zheng

et al. 2023

Preprint

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Background Inflammatory bowel disease (IBD) and its main subtypes, including Crohn's disease (CD) and ulcerative colitis (UC), have been suggested to be linked with chronic obstructive pulmonary disease (COPD) progression, but the potential bidirectional causal association between them remains unclear. Methods We drew on summary statistics from the large-scale genome-wide association studies and adopted the inverse variance weighting (IVW)method as the main mendelian randomization analysis method to estimate the causal effect. Results There was no evidence support that COPD was associated with increased risk of IBD and two main subtypes (UC and CD) (IBD: odds ratio (OR) [95% confidence interval (CI)] = 0.99[0.90–1.09], P = 8.63×10− 1; UC: OR [95% CI] = 0.96[0.86–1.07], P = 4.70×10− 1; CD: OR [95% CI] = 1.10[0.89–1.35], P = 3.81×10− 1;). The IVW method provided evidence for a negative causal effect of IBD and two main subtypes (UC and CD) on COPD (IBD: OR [95% CI] = 0.93[0.89–0.97], P = 4.86×10− 4; UC: OR [95% CI] = 0.94[0.90–0.98], P = 6.57×10− 3; CD: OR [95% CI] = 0.96[0.94–0.99], P = 4.92×10− 3). The results of the sensitivity analyses were robust and no evidence of heterogeneity and horizontal pleiotropy was observed. Conclusions The present study showed that COPD does not affect IBD, but IBD and its main subtypes (UC and CD) have a negative causal effect on COPD. And understanding the confounding factors that affect clinical research will help the clinical treatment and management of the two diseases.

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Mechanism underlying the therapeutic effects of effective component compatibility of Bufei Yishen formula III combined with exercise rehabilitation on chronic obstructive pulmonary disease

Huang,

Guan,

et al. 2024

Annals of Medicine

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Effects of inhaled corticosteroids (ICS) on lung microbiota and local immune response in long-term treatment of chronic obstructive pulmonary disease (COPD): utility of titration and therapeutic index

Cited by 4 publications

References 81 publications

Association Between Adult Antibiotic Use, Microbial Dysbiosis and Atopic Conditions – A Systematic Review

Association Between Adult Antibiotic Use, Microbial Dysbiosis and Atopic Conditions – A Systematic Review

Inflammatory bowel disease has a negative causal effect on chronic obstructive pulmonary disease: A two-sample bidirectional mendelian randomization study

Mechanism underlying the therapeutic effects of effective component compatibility of Bufei Yishen formula III combined with exercise rehabilitation on chronic obstructive pulmonary disease

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