Effects of Inhalation of Corticosteroids Immediately after Experimental Chlorine Gas Lung Injury

Gunnarsson, Mats; Walther, Sten; Seidal, Tomas; Lennquist, Sten

doi:10.1097/00005373-200001000-00017

Cited by 42 publications

(31 citation statements)

References 12 publications

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“…The risk of exposure to chlorine gas with many casualties is widespread, since chlorine is carried through densely populated areas in large quantities (Gunnarsson et al, 2000).…”

Section: Discussionmentioning

confidence: 99%

Long-Term Pulmonary Histopathologic Changes in Rats Following Acute Experimental Exposure to Chlorine Gas

Yıldırım

Koçoğlu

Göksu

et al. 2004

Inhalation Toxicology

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In this study, we aimed to investigate the long-term histopathologic changes in the lungs of rats exposed to a high concentration of chlorine gas. Twenty-four Sprague-Dawley rats were divided into three groups: the control group (group I) (n = 8), early-examined group (group II) (n = 8), and late-examined group (group III) (n = 8). In group II the lungs of rats were taken out just after the exposure, whereas in group III the lungs were taken out 45 days after the exposure. Eosinophilic liquid accumulation in alveoli and bronchi, diffuse intraalveolar edema, vascular congestion, severe perivascular edema, and free bleeding in intraalveolar and interstitial area were observed in the lungs of rats in group II. Interstitial fibrosis and thickening of the alveolar septa were observed in group III. These findings suggest that the people using these cleaning agents are at risk of harming themselves, and the victims of chlorine gas injury should be reexamined at a later period since they may have pulmonary damage even after 45 days of exposure.

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“…The risk of exposure to chlorine gas with many casualties is widespread, since chlorine is carried through densely populated areas in large quantities (Gunnarsson et al, 2000).…”

Section: Discussionmentioning

confidence: 99%

Long-Term Pulmonary Histopathologic Changes in Rats Following Acute Experimental Exposure to Chlorine Gas

Yıldırım

Koçoğlu

Göksu

et al. 2004

Inhalation Toxicology

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“…Therefore, we did not use corticosteroids in the present case. In animal experimental studies, systemic or inhaled corticosteroids showed benefits in pulmonary function recovery immediately after chlorine exposure (13)(14)(15)(16). In a previous case report, the clinical manifestations demonstrated improvement within 5 days with corticosteroid administration (17).…”

Section: Discussionmentioning

confidence: 91%

Acute respiratory distress syndrome and chemical burns after exposure to chlorine-containing bleach: a case report

et al. 2017

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“…They are postulated to abate the inflammatory response, countering the chlorine-mediated decrease in lung compliance and gas exchange, and to be particularly useful in patients with underlying reactive airway disease. However, while there are good data from studies in pigs to suggest effectiveness of this therapy, there is only anecdotal evidence in humans [21][22][23][24].…”

Section: Case Continuationmentioning

confidence: 99%

Case Files of the University of California San Francisco Medical Toxicology Fellowship: Acute Chlorine Gas Inhalation and the Utility of Nebulized Sodium Bicarbonate

Vajner

Lung

2013

J. Med. Toxicol.

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Effects of Inhalation of Corticosteroids Immediately after Experimental Chlorine Gas Lung Injury

Abstract: Immediate treatment with nebulized BDP improved pulmonary and cardiovascular function after experimental chlorine gas injury.

Cited by 42 publications

References 12 publications

Long-Term Pulmonary Histopathologic Changes in Rats Following Acute Experimental Exposure to Chlorine Gas

Long-Term Pulmonary Histopathologic Changes in Rats Following Acute Experimental Exposure to Chlorine Gas

Acute respiratory distress syndrome and chemical burns after exposure to chlorine-containing bleach: a case report

Case Files of the University of California San Francisco Medical Toxicology Fellowship: Acute Chlorine Gas Inhalation and the Utility of Nebulized Sodium Bicarbonate

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