Effects of Ingestion of Difructose Anhydride III (DFA III) and the DFA III-Assimilating Bacterium<i>Ruminococcus productus</i>on Rat Intestine

Minamida, Kimiko; Ohashi, Midori; Hara, Hiroshi; Asano, Kozo; Tomita, Fusao

doi:10.1271/bbb.70.332

Cited by 25 publications

(11 citation statements)

References 28 publications

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“…This could be achieved by administering difructose anhydride III that is shown to decrease secondary bile acid generation, purportedly via inhibiting bacterial 7αdehydroxylase. 7,30 As an alternate means, bile salt hydrolase inhibitors could also be considered for restricting the generation of secondary bile acids. 31 Another viable alternative is to employ β-acids from hops (Humulus lupulus), which we had previously shown to be effective in inhibiting gut fermentation and thus prevent fermenting bacteria from generating SCFAs.…”

Section: Discussionmentioning

confidence: 99%

Vancomycin prevents fermentable fiber-induced liver cancer in mice with dysbiotic gut microbiota

et al. 2020

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Owing to their health benefits, dietary fermentable fibers, such as refined inulin, are increasingly fortified in processed foods to enhance their nutritional value. However, we previously demonstrated that when inulin was fed to Toll-like receptor 5 deficient (T5KO) mice susceptible to dysbiosis, a subset of them developed cholestasis and subsequently liver cancer in a gut microbiotadependent manner. Therefore, we hypothesized that clearance of bacterial taxa, and thereby gut metabolites, involved in the onset and progression to liver cancer could abate the disease in these mice. Such a reshaping of microbiota by vancomycin treatment was sufficient to halt the development of liver cancer in inulin-fed T5KO mice; however, this intervention did not remedy disease penetrance for cholestatic liver injury and its sequelae, including hyperbilirubinemia, hypolipidemia, cholemia and liver fibrosis. Selective depletion of gut bacterial communities was observed in vancomycin-treated mice, including Gram-positive Lachnospiraceae and Ruminococcaceae belonging to the phylum Firmicutes, Bifidobacteria of the phylum Actinobacteria, which ferment fibers, and Clostridium cluster XIVa, which produce secondary bile acids. Lack of liver cancer in vancomycintreated mice strongly correlated with the substantial loss of secondary bile acids in circulation. Although cholemia was unabated by vancomycin, the composition of serum bile acids shifted toward an abundance of hydrophilic primary bile acids, denoted by the increase in conjugated-tounconjugated bile acid ratio. Taken together, the present study suggests that microbiotal regulation of bile acid metabolism is one of the critical mediators of fermentable fiber-induced liver cancer in dysbiotic mice.

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Section: Discussionmentioning

confidence: 99%

Vancomycin prevents fermentable fiber-induced liver cancer in mice with dysbiotic gut microbiota

et al. 2020

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“…Notably, Ruminococcus spp. produce short-chain fatty acids, which are important sources of energy for ruminants ( 76 ). These findings implied that feeding calves PWM may exert beneficial effects on calf health by elevating the abundance of beneficial bacteria in the caecum.…”

Section: Effect Of Wm On Intestinal Microbiota and Microbiology In Th...mentioning

confidence: 99%

“…Calves fed SM increased the relative abundance of the genus Comamonas spp. in the colon ( 76 ), which is associated with the degradation of steroids and various aromatic acids ( 77 ). This means that the hydrolytic and fermentative functions of raw SM in the colon may have been enhanced.…”

Section: Effect Of Wm On Intestinal Microbiota and Microbiology In Th...mentioning

confidence: 99%

An Overview of Waste Milk Feeding Effect on Growth Performance, Metabolism, Antioxidant Status and Immunity of Dairy Calves

Khan

Xiao

et al. 2022

Front. Vet. Sci.

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Waste milk (WM) is a part of the milk produced on dairy farms, which is usually unsuitable for human consumption. The WM contains transition milk, mastitis milk, colostrum, milk with somatic cells, blood (Hemolactia), harmful pathogens, pathogenic and antibiotic residues. Due to the high cost of milk replacer (MR), dairy farmers prefer raw WM to feed their calves. It has been well established that WM has a greater nutritive value than MR. Hence WM can contribute to improved growth, rumen development, and immune-associated parameters when fed to dairy calves. However, feeding raw WM before weaning has continuously raised some critical concerns. The pathogenic load and antibiotic residues in raw WM may increase the risk of diseases and antibacterial resistance in calves. Thus, pasteurization has been recommended as an effective method to decrease the risk of diseases in calves by killing/inhibiting the pathogenic microorganisms in the raw WM. Altogether, the current review provides a brief overview of the interplay between the positive role of raw WM in the overall performance of dairy calves, limitations of raw WM as a feed source and how to overcome these issues arising from feeding raw WM.

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“…DFA III promotes calcium absorption in rats [ 17 , 18 ], humans [ 19 , 20 ], and cattle [ 21 , 22 ]. Furthermore, Minamida et al [ 23 , 24 ] reported that oral administration of DFA III in laboratory animals may help to maintain a healthy balance of intestinal microbiota; they suggested that DFA III is a novel candidate prebiotic. Additionally, we reported on the efficacy of DFA III supplementation as a prebiotic for the improvement in the health and intestinal microbiota of calves [ 25 , 26 ].…”

Section: Introductionmentioning

confidence: 99%

Fructo-Oligosaccharide (DFA III) Feed Supplementation for Mitigation of Mycotoxin Exposure in Cattle—Clinical Evaluation by a Urinary Zearalenone Monitoring System

Toda

Uno

Kokushi

et al. 2018

Toxins

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The potential effect of difructose anhydride III (DFA III) supplementation in cattle feed was evaluated using a previously developed urinary-zearalenone (ZEN) monitoring system. Japanese Black cattle from two beef herds aged 9–10 months were used. DFA III was supplemented for two weeks. ZEN concentrations in feed were similar in both herds (0.27 and 0.22 mg/kg in roughage and concentrates, respectively), and below the maximum allowance in Japan. ZEN, α-zearalenol (α-ZOL), and β-ZOL concentrations in urine were measured using LC/MS/MS the day before DFA III administration, 9 and 14 days thereafter, and 9 days after supplementation ceased. Significant differences in ZEN, α-ZOL, β-ZOL, and total ZEN were recorded on different sampling dates. The concentration of inorganic phosphate in DFA III-supplemented animals was significantly higher than in controls on day 23 (8.4 vs. 7.7 mg/dL), suggesting a possible role of DFA III in tight junction of intestinal epithelial cells. This is the first evidence that DFA III reduces mycotoxin levels reaching the systemic circulation and excreted in urine. This preventive effect may involve an improved tight-junction-dependent intestinal barrier function. Additionally, our practical approach confirmed that monitoring of urinary mycotoxin is useful for evaluating the effects of dietary supplements to prevent mycotoxin adsorption.

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Effects of Ingestion of Difructose Anhydride III (DFA III) and the DFA III-Assimilating BacteriumRuminococcus productuson Rat Intestine

Cited by 25 publications

References 28 publications

Vancomycin prevents fermentable fiber-induced liver cancer in mice with dysbiotic gut microbiota

Vancomycin prevents fermentable fiber-induced liver cancer in mice with dysbiotic gut microbiota

An Overview of Waste Milk Feeding Effect on Growth Performance, Metabolism, Antioxidant Status and Immunity of Dairy Calves

Fructo-Oligosaccharide (DFA III) Feed Supplementation for Mitigation of Mycotoxin Exposure in Cattle—Clinical Evaluation by a Urinary Zearalenone Monitoring System

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