Effects of inflammatory disease on plasma oxprenolol concentrations.

Kendall, M. J.; Quarterman, CP; Bishop, H.; Schneider, R.

doi:10.1136/bmj.2.6188.465

Cited by 31 publications

(9 citation statements)

References 8 publications

(4 reference statements)

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“…However, hepatic drug metabolism may be downregulated also in viral infections, which are generally not associated with significantly increased CRP levels (11,12). Midazolam infusions were not always tapered off as dictated by the sedation protocol.…”

Section: Discussionmentioning

confidence: 99%

The effect of critical illness and inflammation on midazolam therapy in children*

Vet¹,

Hoog²,

Tibboel³

et al. 2012

Pediatric Critical Care Medicine

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Section: Discussionmentioning

confidence: 99%

The effect of critical illness and inflammation on midazolam therapy in children*

Vet¹,

Hoog²,

Tibboel³

et al. 2012

Pediatric Critical Care Medicine

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“…Such inflammation-associated changes, which are collectively known as acute-phase responses, can result in profound increases in the plasma concentrations of various drugs, thereby causing toxic effects [1][2][3][4][5]. It was reported that cytochrome P-450 and chiral inversion activities are decreased in adjuvant-induced arthritis (AA) rats [6,7].…”

Section: Introductionmentioning

confidence: 99%

Changes in mRNA expression of ABC and SLC transporters in liver and intestines of the adjuvant‐induced arthritis rat

Uno

Uraki

Ito

et al. 2009

Biopharm & Drug Disp

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In this study, a real-time reverse transcription-polymerase chain reaction was used to determine the effects of adjuvant-induced arthritis (AA) on the amounts of mRNA of 12 types of rat ATP-binding cassette (ABC) and solute carrier (SLC) transporters in the liver and small intestine, 7 (D7) and 21 days (D21) after the injection of adjuvant. There were no significant differences in mRNA levels of ABC and SLC transporters between the livers of AA and control rats on D7, except in the case of Mdr1a. However, levels of Mdr1a, Mrp2 and Oatp SLC transporters were significantly lower in AA than in the control livers on D21. In contrast, the mRNA levels of several ABC and SLC transporters, especially Mrp2, Bcrp, LAT2 and Oatp1a5, were significantly lower in the small intestines of AA rats compared with the controls on D7, though there were no significant differences by D21. The time-dependent alterations in mRNA levels of the pregnane X receptor, but not the constitutive androstane receptor, in the liver and intestine were similar to the changes in mRNA levels of most transporters examined. The present study showed that AA was associated with reduced mRNA expression of several ABC and SLC transporters in the liver and small intestine, but that the time courses of the effects of AA on mRNA expression differed between the liver and small intestine. These results raise the possibility of a functional change of the transporters of liver and intestine in AA rats.

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“…The effect of increased binding on the pharmacokinetics of these drugs has been evaluated in several studies. After oral administration the serum concentrations of propranolol and oxprenolol are higher when inflammation is present, in man (Schneider et al, 1976;Kendall et al, 1979) as well as in animals (Belpaire et al, 1981;Bishop et al, 1981;Barber et al, 1983). After intravenous administration, there is still a difference between serum concentrations of the P-adrenoceptor blockers in healthy and diseased individuals, in man (De Leve & Piafsky, 1981;Waller et al, 1982) and experimental animals (Belpaire et al, 1981;Bishop et al, 1981;Barber et al, 1983), but it is less pronounced.…”

Section: Introductionmentioning

confidence: 99%

Binding to serum α₁‐acid glycoprotein and effect of β‐adrenoceptor antagonists in rats with inflammation

Belpaire

Bogaert

Mugabo

et al. 1986

British J Pharmacology

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1 The P-blocking effect of 4 P-adrenoceptor antagonists with different pharmacokinetic properties was studied after intravenous and intraportal administration to control rats and to rats with experimental inflammation. 2 In rats with inflammation the effects of propranolol and oxprenolol, which are mainly bound to a,-acid glycoprotein (ax-AGP), were significantly less after intravenous administration, but not after intraportal administration. In contrast, for metoprolol and atenolol, which are only negligibly serum bound, no difference was observed between control rats and rats with inflammation for either route of administration. 3 Total and unbound serum concentrations of propranolol were measured 20 min after intravenous and intraportal administration. 4 After intravenous administration, in the rats with inflammation total concentrations of propranolol were more than twice, and unbound concentrations less than half those of control rats. After intraportal administration the total concentrations were 8 times, and the unbound concentrations 3 times higher in the rats with inflammation. 5There was a significant correlation between the P-blocking effect and the unbound concentrations of propranolol after intravenous administration, but not after intraportal administration. The latter finding is probably because the unbound concentrations were supramaximal.

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Effects of inflammatory disease on plasma oxprenolol concentrations.

Cited by 31 publications

References 8 publications

The effect of critical illness and inflammation on midazolam therapy in children*

The effect of critical illness and inflammation on midazolam therapy in children*

Changes in mRNA expression of ABC and SLC transporters in liver and intestines of the adjuvant‐induced arthritis rat

Binding to serum α₁‐acid glycoprotein and effect of β‐adrenoceptor antagonists in rats with inflammation

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Effects of inflammatory disease on plasma oxprenolol concentrations.

Cited by 31 publications

References 8 publications

The effect of critical illness and inflammation on midazolam therapy in children*

The effect of critical illness and inflammation on midazolam therapy in children*

Changes in mRNA expression of ABC and SLC transporters in liver and intestines of the adjuvant‐induced arthritis rat

Binding to serum α1‐acid glycoprotein and effect of β‐adrenoceptor antagonists in rats with inflammation

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Binding to serum α₁‐acid glycoprotein and effect of β‐adrenoceptor antagonists in rats with inflammation