Effects of infant flow Bi‐NCPAP on apnea of prematurity

Ishihara, Chie; Ibara, Satoshi; Ohsone, Yoshiteru; Kato, Eiji; Tokuhisa, Takuya; Yamamoto, Yutaka; Maede, Yoshinobu; Kuwahara, Takako; Minakami, Hisanori

doi:10.1111/ped.12854

Cited by 8 publications

(9 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Of the eight studies, three used synchronized NIPPV 14,19,21 and two used bi-level CPAP. 22,23 However, there was noted heterogeneity (I 2 ¼ 50%) and test for overall effect (p ¼ 0.5). As shown in ►Fig.…”

Section: Resultsmentioning

confidence: 99%

Nasal Intermittent Positive Pressure Ventilation versus Continuous Positive Airway Pressure and Apnea of Prematurity: A Systematic Review and Meta-Analysis

et al. 2021

View full text Add to dashboard Cite

Objective The study aimed to systematically review and analyze the impact of nasal intermittent positive pressure ventilation (NIPPV) versus continuous positive airway pressure (CPAP) on apnea of prematurity (AOP) in preterm neonates. Study Design In this systematic review and meta-analysis, experimental studies enrolling preterm infants comparing NIPPV (synchronized, nonsynchronized, and bi-level) and CPAP (all types) were searched in multiple databases and screened for the assessment of AOP. Primary outcome was AOP frequency per hour (as defined by authors of included studies). Results Out of 4,980 articles identified, 18 studies were included with eight studies contributing to the primary outcome. All studies had a high risk of bias, with significant heterogeneity in definition and measurement of AOP. There was no difference in AOPs per hour between NIPPV versus CPAP (weighted mean difference = −0.19; 95% confidence interval [CI]: −0.76 to 0.37; eight studies, 456 patients). However, in a post hoc analysis evaluating the presence of any AOP (over varying time periods), the pooled odds ratio (OR) was lower with NIPPV (OR: 0.46; 95% CI: 0.32–0.67; 10 studies, 872 patients). Conclusion NIPPV was not associated with decrease in AOP frequency, although demonstrated lower odds of developing any AOP. However, definite recommendations cannot be made based on the quality of the published evidence. Key Points

show abstract

Section: Resultsmentioning

confidence: 99%

Nasal Intermittent Positive Pressure Ventilation versus Continuous Positive Airway Pressure and Apnea of Prematurity: A Systematic Review and Meta-Analysis

et al. 2021

View full text Add to dashboard Cite

show abstract

“…In this population subset, long term use of intubation and mechanical ventilation can lead to bronchopulmonary dysplasia a form of chronic lung disease. To reduce longterm mechanical ventilation, nasal continuous positive airway pressure (NCPAP) at pressures of 4-6 cm H 2 O and xanthine therapy is used to shorten the intubation by as much as 1 week (Ishihara et al, 2016). This is effective due to upper airway "splinting" that prevents pharyngeal and laryngeal airway obstruction.…”

Section: Apnea Of Prematuritymentioning

confidence: 99%

“…Additionally, this treatment increases the oxygenation of the infant by increasing the functional residual capacity and allows better control of blood gases. Recent studies have suggested that regular NCPAP may cause respiratory distress and necessitate early intubation (Ishihara et al, 2016;Lista et al, 2010;Rong et al, 2016). An alternative treatment to regular NCPAP is biphasic NCPAP, which produces a cyclic change between the upper and lower baseline level pressures (Eichenwald, 2016;Ishihara et al, 2016;Martin & Wilson, 2009).…”

Section: Apnea Of Prematuritymentioning

confidence: 99%

“…Recent studies have suggested that regular NCPAP may cause respiratory distress and necessitate early intubation (Ishihara et al, 2016;Lista et al, 2010;Rong et al, 2016). An alternative treatment to regular NCPAP is biphasic NCPAP, which produces a cyclic change between the upper and lower baseline level pressures (Eichenwald, 2016;Ishihara et al, 2016;Martin & Wilson, 2009). Currently bi-level NCPAP appears to be an effective early respiratory strategy for preterm infants to avoid intubation and mechanical ventilation (Nasef, Rashed, & Aly, 2020).…”

Section: Apnea Of Prematuritymentioning

confidence: 99%

See 1 more Smart Citation

An overview of developmental dysregulation of autonomic control in infants

Altamirano

Wilson²

2021

Birth Defects Research

View full text Add to dashboard Cite

In this short review, we provide an overview of developmental disorders causing autonomic nervous system dysregulation. We briefly discuss perinatal conditions that adversely impact developmental outcomes including apnea of prematurity, sudden infant death syndrome, and Rett syndrome. We provide a brief clinical description, an overview of known or hypothesized mechanisms for the disorder, and current standard of practice for treatment of each condition. Additionally, we consider preventative measures and complications of these disorders to provide further insight into the pathogenesis of specific autonomic dysregulation in neonates. The goal of this short review is to provide an updated understanding of the impact of autonomic dysregulation on development of brainstem circuits and to briefly highlight promising future treatment options and controversies.

show abstract

“…Combined with the nasal continuous positive airway pressure ventilation (nCPAP), methylxanthines are able to reduce the incidence of apneic episodes and have become one of the common medicine used in neonatal intensive care unit (NICU). Methylxanthines can act by raising central sensitivity to CO2 concentration and improving respiratory muscle function (8), which together lead to an increase in minute ventilation (9,10). Recently, caffeine treatment has been reported to improve the rate of survival without neurodevelopmental disability in premature infants of very low birth weight (10), which displays different effects on premature infants by improving breath effort (11,12).…”

mentioning

confidence: 99%

Caffeine citrate improves outcomes of apnea of prematurity based on gestational ages

Zhao¹,

Li²,

Wang³

et al. 2019

Preprint

View full text Add to dashboard Cite

ObjectiveThis study aimed to evaluate the therapeutic effect of caffeine citrate on early premature infants with apnea of prematurity (AOP), and the impact on movement and neurobehavioral development in their early lives.Study designAmongst 397 premature infants whose gestational age (GA) were less than 32 weeks, 172 premature infants were eligible for this study from January 2014 to May 2017. 94 infants received caffeine citrate intervention, 20 infants were given aminophyline and the rest 58 infants didn't received any methylxanthines. According to the incidence of apnea, caffeine using was divided into two situations of therapeutic and preventive administration. The primary clinical outcomes were recorded which included length of stay (LOS), duration of mechanical ventilation, the incidence of complications and outcomes.Results62 cases (66%) were assigned to receive caffeine within 3 days after birth, and 69 cases (74%) received caffeine less than one month. Caffeine could reduce LOS, duration of MV and nasal continues positive airway pressure (nCPAP), the incidence of nosocomial infection and bronchial pulmonary dysplasia (BPD) (p<0.05). There was no significant difference in the incidence of abdominal distension, necrotizing enterocolitis (NEC), patent ductus arteriosus (PDA) and intraventricular hemorrhage (IVH) compared with aminophylline and conservative groups (P >0.05). Caffeine showed different effects on clinical outcomes in early premature infants based on their GAs, and premature infants with larger GA could benefit more from the intervention (p<0.001), and caffeine didn’t affect their early lives in short-term prognosis by follow-up.Conclusion Caffeine can improve AOP clinical outcomes in those premature infants with larger GA, and didn't have side effects on the movement and neurobehavioral development in short-term prognosis.

show abstract

Effects of infant flow Bi‐NCPAP on apnea of prematurity

Cited by 8 publications

References 16 publications

Nasal Intermittent Positive Pressure Ventilation versus Continuous Positive Airway Pressure and Apnea of Prematurity: A Systematic Review and Meta-Analysis

Nasal Intermittent Positive Pressure Ventilation versus Continuous Positive Airway Pressure and Apnea of Prematurity: A Systematic Review and Meta-Analysis

An overview of developmental dysregulation of autonomic control in infants

Caffeine citrate improves outcomes of apnea of prematurity based on gestational ages

Contact Info

Product

Resources

About