Effects of induction therapy on wound healing at bronchial anastomosis sites in rats

Abstract

Our study suggests that induction chemotherapy, associated with leukopenia in the early phase of wound healing, increases the risk of bronchial anastomosis leakage. Postoperative macrophage depletion is one of the most important causes of impaired wound healing.

Liposome-Encapsulated Hemoglobin Accelerates Bronchial Healing After Pneumonectomy in the Rat With or Without Preoperative Radiotherapy

“…The infiltrated macrophages in and around the wound, probably attracted by the xenogeneic nature of human hemoglobin, might have amplified cytokine production to further accelerate wound healing. This possibility could be examined by the use of antimacrophage antibody, as in the study by Shirafuji et al (23), to determine whether it reduces the benefits afforded by LEH. Because intravenous LEH administration per se causes reduced accumulation of hypoxia-inducible factor-1alpha (HIF-1alpha) in tumors (15) as well as in gastric wounds (17), LEH may perfuse, supply O2, and maintain aerobic metabolism to suppress successive HIF-1alpha signal transduction in the nucleus that initiates an inflammatory cascade (24).…”

The effects of granulocyte colony-stimulating factor on the healing of tracheal anastomosis following radiation therapy in rats

“…Therefore, radiation therapy might impair the tracheal anastomosis with a resultant increase in complications [4]. As a consequence, attempts at improved healing and reduced complications following tracheal anastomosis should intervene with one or more of the interdependent measures of inflammation, angiogenesis, connective tissue regeneration and epithelial regeneration through modulatory effects on the endogenous mediators involved in the healing process such as cytokines and growth factors.…”