“…Among different cell types, the apparent discrepancy between expression of TP73 variants at the RNA and protein levels suggests that post-translational modifications also contribute to observed levels. Like other transcription factors, TP73 variants are regulated by a variety of positive and negative networks involving: E2F1, MDM2, Sumo-1, c-Abl, NEDL2, and other DNA damage response factors [21,44]. Such complex regulatory influences probably account for the dynamic expression levels of TP73 , as seen with p53.…”