Effects of induced hypothyroidism or hyperthyroidism on growth and reproductive performance of Brahman heifers.

Thrift, Todd; Bernal, Andrés López; Lewis, Andy; Neuendorff, D. A.; Willard, C C; Randel, R. D.

doi:10.2527/1999.7771833x

Cited by 19 publications

(16 citation statements)

References 21 publications

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“…Propylthiouracil had been repeatedly shown to draw this response in goats (Villar et al, 1998;2000;AlTamimi, in press-b), sheep (Al-Tamimi et al, 1998;Hernandez et al, 2003), and cattle (Thrift et al, 1999). In agreement with the previous literature, PTU administration in the current trial at 20 mg/kg BW/day is sufficient in eliciting a reversible antithyroidal reaction.…”

Section: Discussionsupporting

confidence: 88%

Responses of simultaneously recorded intraperitoneal and subcutaneous temperatures of Black Bedouin goats to transient thyrosuppression during cold stress

Al-Tamimi

2007

Livestock Science

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Section: Discussionsupporting

confidence: 88%

Responses of simultaneously recorded intraperitoneal and subcutaneous temperatures of Black Bedouin goats to transient thyrosuppression during cold stress

Al-Tamimi

2007

Livestock Science

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“…(1991) who propose plasma concentrations of T 3 vary inversely with ambient temperature, suggesting temperature is associated with the increase in serum T 3 observed in the post‐treatment period. However, temporary hyperthyroidism is a common side effect in humans who have PTU treatments terminated (LaFranchi and Mandel 1996) and has also been commonly observed in animal studies utilizing PTU (Thrift et al. 1999a, 1999b; Bollinger et al.…”

Section: Discussionmentioning

confidence: 99%

“…Increased gains in BW have been observed with cattle receiving PTU (Bernal et al. 1999; Thrift et al. 1999a, 1999b).…”

Section: Discussionmentioning

confidence: 99%

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Effect of the thyroid on faecal shedding of E. coli O157:H7 and Escherichia coli in naturally infected yearling beef cattle*

Schultz¹,

Edrington²,

Schroeder³

et al. 2005

J Appl Microbiol

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Aims:To determine if thyroid function affects faecal shedding of Escherichia coli O157:H7. Methods and Results: Eight yearling cattle (n ¼ 4 per treatment group), previously identified as shedding E. coli O157:H7, received either 0 or 10 mg 6-N-propyl-2-thiouracil (PTU) kg )1 BW day )1 for 14 days to reduce serum concentrations of the thyroid hormones, T 3 and T 4 . Animals were monitored daily for changes in faecal shedding of E. coli O157:H7 and E. coli (EC) for the 14-day treatment period and an additional 7 days post-treatment. Body weight was measured weekly and serum concentrations of T 3 and T 4 were determined every 3 days. No differences in faecal shedding of E. coli O157:H7 were observed during the 14-day treatment period. However, compared with control animals, a greater percentage of PTU-treated cattle ejected E. coli O157:H7 on day 16 (100 vs 25%) and 18 (75 vs 0%) of the post-treatment period. Serum T 3 was lower in PTU-treated cattle during the 14-day treatment period and greater on day 18 of the post-treatment period. Conclusion: Cattle with chemically altered thyroid hormones had similar shedding patterns of faecal E. coli O157:H7 and EC during the 14-day treatment period. However, faecal shedding of E. coli O157:H7 tended to be greater, and serum concentrations of T 3 , were greater for PTU-treated cattle immediately following the termination of PTU treatment. Significance and Impact of the Study: Short-term chemical inhibition of thyroid hormones had minimal effects on faecal shedding of E. coli O157:H7 in naturally infected cattle. However, a hyperthyroid state as observed postdosing might play a role in the seasonal shedding of E. coli O157:H7 in cattle.

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“…PTU effect is dose-dependent and reversible [17]. It was earlier proved that PTU in doses of 4 mg/kg body weight (BW), by acting on central and peripheral level, signifi cantly decreases both T 4 and T 3 in dams treated in daily fashion [18][19][20]. Doses of 1-2 mg/kg BW per day only inhibit the peripheral conversion of T 4 in T 3 [21,22].…”

Section: Introductionmentioning

confidence: 99%

Placental Iodothyronine Deiodinases Expression in Pregnant Cows Exposed to Propylthiouracil (Ptu) and Thyroid Axis Activity of their Calves

et al. 2016

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The aim of our study was to investigate if the thyroid axis of newborn calves is affected by prenatal application of propylthyouracil (PTU). The study included 20 late pregnant Holstein cows. One group (n=10) was treated with PTU (4 mg/kg of BW daily) from day 20 before expected calving until the day of calving. The other group (n=10) was non-treated. Placental samples of dams were obtained for measuring mRNA expression of iodothyronine deiodinases type I (D1), type II (D2) and type III (D3). After parturition calves were separated from the dams and included in the study. Blood samples were taken daily from each calf starting on the day of birth until day 7 of age. Blood T 3, T 4 and TSH concentrations were measured. PCR analysis of the placental tissue revealed an abundance of all three types of placental deiodinases in non-treated cows, and a signifi cant elevation of mRNA levels for all three types of deiodinases after PTU treatment. Calves that originated from dams treated with PTU had signifi cantly lower T 3 and T 4 and signifi cantly higher TSH concentrations compared to non-treated calves during the fi rst 2 days of life. Starting from day 4 until day 6 of life the opposite effect was observed meaning that calves prenatally exposed to PTU had signifi cantly higher T 3 and T 4 and slightly lower TSH. Our study, for the fi rst time, provides information related to iodothyronine deiodinases mRNA expression in bovine placenta, and confi rm that PTU treatment of pregnant dams provokes depression of thyroid function in newborns during the fi rst days of life.

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Effects of induced hypothyroidism or hyperthyroidism on growth and reproductive performance of Brahman heifers.

Cited by 19 publications

References 21 publications

Responses of simultaneously recorded intraperitoneal and subcutaneous temperatures of Black Bedouin goats to transient thyrosuppression during cold stress

Responses of simultaneously recorded intraperitoneal and subcutaneous temperatures of Black Bedouin goats to transient thyrosuppression during cold stress

Effect of the thyroid on faecal shedding of E. coli O157:H7 and Escherichia coli in naturally infected yearling beef cattle*

Placental Iodothyronine Deiodinases Expression in Pregnant Cows Exposed to Propylthiouracil (Ptu) and Thyroid Axis Activity of their Calves

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