Effects of Indocyanine Green Injection on the Retinal Surface and Into the Subretinal Space in Rabbits

Maia, Maurício; Kellner, Lukas; Juan, Eugene de; Smith, Ricardo Luiz; Farah, Michel Eid; Margalit, Eyal; Lakhanpal, Rohit R.; Grebe, Lynnea; Eong, Kah‐Guan Au; Humayun, Mark S.

doi:10.1097/00006982-200402000-00012

Cited by 90 publications

(66 citation statements)

References 24 publications

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“…Alterations of the plane of separation between the ILM and the underlying neurosensory retina have also been observed on electron microscopy (14)(15)(16). In vitro and in vivo experimental studies demonstrated direct toxicity of ICG on the pigment epithelium and neurosensory re t i n a (11,(17)(18)(19). These adverse effects were correlated with the sodium concentration in the ICG solvent (20,21), osmolarity (10,22), ICG exposure time (17), and the concentration of the solution (8)(9)(10)(23)(24)(25)(26).…”

Section: Discussionmentioning

confidence: 90%

Visual Acuity after Vitrectomy and Epiretinal Membrane Peeling with or without Premacular Indocyanine Green Injection

2005

European Journal of Ophthalmology

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Section: Discussionmentioning

confidence: 90%

Visual Acuity after Vitrectomy and Epiretinal Membrane Peeling with or without Premacular Indocyanine Green Injection

2005

European Journal of Ophthalmology

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“…Several reports 49,[62][63][64] evaluated the potential toxicity of ICG, at different concentrations, injected into the subretinal space in animal models. The rational for this approach is to simulate the contact that occurs between ICG and the RPE and photoreceptors when the dye is applied to full-thickness macular holes.…”

Section: Animal Studiesmentioning

confidence: 99%

Vital staining with indocyanine green: a review of the clinical and experimental studies relating to safety

Stanescu-Segall

Jackson

2008

Eye

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Indocyanine green (ICG) is extremely effective when used as a vital stain during macular hole surgery. By staining the internal limiting membrane, ICG facilitates removal of this delicate and sometimes hard to visualize structure. There is, however, considerable debate regarding its safety. This review considers the clinical and experimental studies of ICG and a related agent, infracyanine green. Some clinical papers show visual field defects, reduced visual acuity, and persistence of ICG at the macula and optic nerve. Other clinical studies fail to demonstrate toxicity. The experimental studies are also conflicting, but there are emerging trends. These suggest that surgeons who continue to use ICG should use concentrations not greater than 0.05 mg/ml, in fluid-filled eyes, with short exposure times, iso-osmolar solutions, and avoid proximal or prolonged endoillumination of stained tissue. A smaller number of studies suggest that infracyanine green produces similar staining to ICG, and may possibly be safer, but there are too few well-designed studies to reach a conclusion. Although the use of ICG continues, on the balance of evidence, this review suggests that it is has the potential to produce subtle visual damage.

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“…Macular hole (MH) closure rate may be achieved in 74 to 100% of patients using ICG-guided ILM peeling (4,8) . However, the potential for toxic effects of ICG on the re- and hyperfluorescent image at the topography of the previous macular hole position (arrowhead) due to probable window defects related to RPE atrophic changes tina has been suggested (9)(10)(11) . ICG may persist after macular hole surgery for up to 36 months (4) .…”

Section: Indocyanine Greenmentioning

confidence: 99%

“…Most of the studies in this meta-analysis used ICG in high concentrations and volumes. The hypotheses of RPE toxicity to retina is based on 2 different mechanisms: 1) The iodine/singlet oxygen released by the ICG molecule especially if irradiated by light and its metabolic derivates damage the RPE (9)(10)(11) ; 2) The ICG may affect the cleavage plan from the ILM/neurosensory retina resulting in damage to the retina due to removal of Muller and glia cells during the peeling procedure (23) . ICG has been also used to facilitate ILM peeling in other diseases.…”

Section: Indocyanine Greenmentioning

confidence: 99%

State of the art in chromovitrectomy

Caiado¹,

Moraes-Filho²,

Maia³

et al. 2014

Revista Brasileira De Oftalmologia

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Vitrectomy is a surgery that involves complex and delicate techniques that treat diseases such as macular hole, epiretinal membrane and diabetic macular edema. Chromovitrectomy is one of these techniques and includes the use of coloring agents such as vital dyes or crystals to enhanced visibility of transparent structures during vitrectomy. The aim of this study was to present a modern approach, based on scientific evidence, about the application and indication of vital coloring agents during vitrectomy. The use of such agents has made this surgery more predictable and has increased its post-operative prognosis. Although research on chromovitrectomy is currently expanding there is still not an established gold standard dyeing agent.Keywords: Vitrectomy; Vitreous body; Macular hole; Retina; Dyeing agents; Epiretinal membrane RESUMOA cirurgia vitreorretiniana é uma cirurgia que envolve técnicas complexas e delicadas que tratam doenças como buraco macular, membrana epirretiniana e o edema macular diabético. A cromovitrectomia é uma dessas técnicas que incluem o uso de corantes compostos de pigmentos vitais ou cristais para melhorar a visibilização de estruturas transparentes durante a cirurgia de vitrectomia. O objetivo desse artigo foi apresentar uma abordagem atual, baseada em evidências, sobre a aplicação e indicação de corantes vitais durante a cirurgia vitreorretiniana. O emprego desses corantes possibilitou uma maior previsibilidade para a cirurgia, melhorando assim seu prognóstico pós-operatório. Apesar do campo da cromovitrectomia está em plena expansão de pesquisas, um corante gold standard para cromovitrectomia ainda não está estabelecido.

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Effects of Indocyanine Green Injection on the Retinal Surface and Into the Subretinal Space in Rabbits

Cited by 90 publications

References 24 publications

Visual Acuity after Vitrectomy and Epiretinal Membrane Peeling with or without Premacular Indocyanine Green Injection

Visual Acuity after Vitrectomy and Epiretinal Membrane Peeling with or without Premacular Indocyanine Green Injection

Vital staining with indocyanine green: a review of the clinical and experimental studies relating to safety

State of the art in chromovitrectomy

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