Effects of individual housing on circadian rhythms of adult rats

Greco, Anna Maria; Gambardella, P; Sticchi, R; D'Aponte, D; Renzo, Gianfranco Di; Franciscis, P De

doi:10.1016/0031-9384(89)90141-8

Cited by 39 publications

(16 citation statements)

References 9 publications

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“…Stress is capable of perturbing this temporal organization by affecting the shape and amplitude of a rhythm or by modifying the intrinsic oscillatory mechanism itself. In particular, social stress in rodents has been found to cause disruptions of the circadian rhythms of body temperature, heart rate and locomotor activity (Greco et al, 1989;Sgoifo et al, 2002;Spani et al, 2003). Further experiments are needed to assess whether the changes in amplitude as well in timing of 24-h rhythms of stress-related hormones seen in socially isolated rats can be attributed either to an effect on the endogenous clock that modulates the circadian variation of hormone release or to a masking effect on some output(s) of the clock.…”

Section: Discussionmentioning

confidence: 99%

Effect of social isolation on 24-h pattern of stress hormones and leptin in rats

et al. 2006

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Section: Discussionmentioning

confidence: 99%

Effect of social isolation on 24-h pattern of stress hormones and leptin in rats

et al. 2006

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“…Stress is also capable of perturbing temporal organization by affecting the shape and amplitude of a rhythm or by modifying the intrinsic oscillatory mechanism itself. In particular, social stress in rodents has been found to cause disruptions of the body temperature, heart rate, and locomotor activity rhythms (see, e.g., [16][17][18]). …”

mentioning

confidence: 99%

Neuroendocrine-immune correlates of circadian physiology: studies in experimental models of arthritis, ethanol feeding, aging, social isolation, and calorie restriction

Esquifino

Cano

Jiménez-Ortega

et al. 2007

Endocr

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Virtually all neuroendocrine and immunological variables investigated in animals and humans display biological periodicity. Circadian rhythmicity is revealed for every hormone in circulation as well as for circulating immune cells, lymphocyte metabolism and transformability, cytokines, receptors, and adhesion molecules. Clock genes, notably the three Period (Per1/Per2/Per3) genes and two Cryptochrome (Cry1/Cry2) genes, are present in immune and endocrine cells and are expressed in a circadian manner in human cells. This review discusses the circadian disruption of hormone release and immune-related mechanisms in several animal models in which circulating cytokines are modified including rat adjuvant arthritis, social isolation in rats and rabbits and alcoholism, the aging process and calorie restriction in rats. In every case the experimental manipulation used perturbed the temporal organization by affecting the shape and amplitude of a rhythm or by modifying the intrinsic oscillatory mechanism itself.

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“…Pow dered food (Purina rodent chow) and distilled water were unrestricted throughout the 48-hour cycle. Since the number of animals per cage is an important consid eration in chronobiologic studies [17], each rat was housed in an individualized wire-bottom metabolism cage (Nalge). All animals were housed in humidityand tem perature-controlled rooms maintained by ani mal care personnel of the University of Houston.…”

Section: Animal Modelmentioning

confidence: 99%

Circadian Variation in Renal Function of the Obese Rat

Luke¹,

Vadiei²

1991

Kidney Blood Press Res

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The influence of food and water intake on renal function was assessed by comparisons between the hyperphagic Zucker obese rat and its lean littermate, which demonstrates nocturnal dominance in activity. Serum creatinine and cortisol levels, creatine kinase activities, creatinine and urine clearances, and sodium and potassium excretion rates were measured over a 24-hour period in both lean and obese rats (n = 24 each). Six rats in each group were studied every 8 h to permit characterization over a 12-hour light/dark cycle at 2-hour intervals. Urine and creatinine clearances were increased in lean rats during the dark phase coincident with onset of eating. Similarly, renal sodium and potassium excretion rates were markedly increased during the dark cycle, despite relatively constant serum potassium and sodium levels over the 24-hour period. In contrast, no circadian patterns in urine and creatinine clearances were found in the obese rat, which exhibits continuous feeding habits throughout the 24-hour period. Moreover, renal electrolyte excretion in the obese rat was modestly increased during the dark cycle, unlike the significant differences over time observed in lean rats. Serum creatinine levels were increased during the dark cycle in both rat groups. Creatine kinase activity, a measure of ambulatory activity, was constant in lean rats during the study period. Although creatine kinase activity was increased in obese rats during the dark cycle, no correlations with renal functional parameters were found. These results indicate that differences in food and water intake are significant determinants in diurnal cyclic changes in renal function.

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Effects of individual housing on circadian rhythms of adult rats

Cited by 39 publications

References 9 publications

Effect of social isolation on 24-h pattern of stress hormones and leptin in rats

Effect of social isolation on 24-h pattern of stress hormones and leptin in rats

Neuroendocrine-immune correlates of circadian physiology: studies in experimental models of arthritis, ethanol feeding, aging, social isolation, and calorie restriction

Circadian Variation in Renal Function of the Obese Rat

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