Effects of increasing infusion rates of dopamine, dobutamine, epinephrine, and phenylephrine in healthy anesthetized cats

Pascoe, Peter J; Ilkiw, Jan E.; Pypendop, Bruno H.

doi:10.2460/ajvr.67.9.1491

Cited by 60 publications

(65 citation statements)

References 28 publications

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“…Dobutamine is a synthetic catecholamine, which directly increases myocardial contractility by stimulating β 1 -adrenergic receptors and reverses anesthetic-induced hypotension in small animals [19, 24] and horses [5, 6, 7, 17, 22]. On the other hand, dobutamine is known to increase myocardial oxygen consumption and sometimes induce tachycardia and ventricular arrhythmias [15].…”

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confidence: 99%

Cardiovascular Effects of Dobutamine and Phenylephrine Infusion in Sevoflurane-anesthetized Thoroughbred Horses

Ohta

Kurimoto

Ishikawa

et al. 2013

The Journal of Veterinary Medical Science

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To determine dose-dependent cardiovascular effects of dobutamine and phenylephrine during anesthesia in horses, increasing doses of dobutamine and phenylephrine were infused to 6 healthy Thoroughbred horses. Anesthesia was induced with xylazine, guaifenesin and thiopental and maintained with sevoflurane at 2.8% of end-tidal concentration in all horses. The horses were positioned in right lateral recumbency and infused 3 increasing doses of dobutamine (0.5, 1.0 and 2.0 µg/kg/min) for 15 min each dose. Following to 30 min of reversal period, 3 increasing doses of phenylephrine (0.25, 0.5 and 1.0 µg/kg/min) were infused. Cardiovascular parameters were measured before and at the end of each 15-min infusion period for each drug. Blood samples were collected every 5 min during phenylephrine infusion period. There were no significant changes in heart rate throughout the infusion period. Both dobutamine and phenylephrine reversed sevoflurane-induced hypotension. Dobutamine increased both mean arterial blood pressure (MAP) and cardiac output (CO) as the result of the increase in stroke volume, whereas phenylephrine increased MAP but decreased CO as the result of the increase in systemic vascular resistance. Plasma phenylephrine concentration increased dose-dependently, and these values at 15, 30 and 45 min were 6.2 ± 1.2, 17.0 ± 4.8 and 37.9 ± 7.3 ng/ml, respectively.

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confidence: 99%

Cardiovascular Effects of Dobutamine and Phenylephrine Infusion in Sevoflurane-anesthetized Thoroughbred Horses

Ohta

Kurimoto

Ishikawa

et al. 2013

The Journal of Veterinary Medical Science

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“…Therefore, these issues (bradycardia and hypotension) were not surprising and highlight the need of judicious anesthetic monitoring, fluid therapy and early treatment of intraoperative complications. Inotropes and vasopressors were administered in order to provide cardiovascular support by increasing myocardial contractility, hemoglobin concentrations, and oxygen delivery [24]. Hypocapnia might have been the result of dilution of the carbon dioxide within the gas sample when using high-fresh gas flows in non-rebreathing systems.…”

Section: Discussionmentioning

confidence: 99%

A retrospective study of anesthesia for subcutaneous ureteral bypass placement in cats: 27 cases

Luca

Monteiro

Dunn

et al. 2017

The Journal of Veterinary Medical Science

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The goals of this retrospective clinical case series study were to describe the management of anesthesia, and to report perioperative complications in cats undergoing subcutaneous ureteral bypass (SUB) placement due to ureteral obstruction. Medical records of client-owned cats with ureteral obstruction and anesthetized for SUB placement between 2012 and 2015 in a veterinary teaching hospital were reviewed. Twenty-seven cases were identified. Duration of anesthesia and surgery (mean ± standard deviation) were 215 ± 42 min and 148 ± 36 min, respectively. Hypothermia was the most common intraoperative complication. Hypotension, hypocapnia, hypertension and bradycardia were also frequently observed. Out of 22 cats who experienced intraoperative hypotension, 17 received inotropes and vasopressors. There was a significant decrease in creatinine (P=0.008) and total solids (P=0.007) after SUB placement when compared with baseline values. Postoperative complications included pain, anorexia, nausea, hypertension, and urinary tract-related problems. No death occurred in the postoperative period. Successful management of anesthesia for SUB placement involves rigorous anesthetic monitoring and immediate treatment of complications. Perioperative complications appear to be common. This study could not identify risk factors associated with this procedure.

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“…hypotension is very common during anesthesia (PASCOE et al, 2006). Thus, it was possible to see if tepoxalin favored a possible worsening of renal ischemia, common in hypotension (POWER et al, 1992;PERKOWSKI & WETMORE, 2006).…”

Section: Discussionmentioning

confidence: 99%

Tepoxalin on renal function and liver enzymes in cats exposed to hypotension with isoflurane

et al. 2014

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Effects of increasing infusion rates of dopamine, dobutamine, epinephrine, and phenylephrine in healthy anesthetized cats

Cited by 60 publications

References 28 publications

Cardiovascular Effects of Dobutamine and Phenylephrine Infusion in Sevoflurane-anesthetized Thoroughbred Horses

Cardiovascular Effects of Dobutamine and Phenylephrine Infusion in Sevoflurane-anesthetized Thoroughbred Horses

A retrospective study of anesthesia for subcutaneous ureteral bypass placement in cats: 27 cases

Tepoxalin on renal function and liver enzymes in cats exposed to hypotension with isoflurane

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