Effects of Increased Neuromuscular Activity at Altered Thyroid Hormone Levels on Myosin Expression

Kirschbaum, Bernhard J.; Kucher, H.-B.; Kelly, A.M.T.; Pett, DH

doi:10.1515/9783110884784-038

Cited by 5 publications

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“…Thus, dynamic regulation of mRNA and protein expression is of fundamental importance. Gene expression in muscle is known to respond to chronic low‐frequency stimulation, caloric restriction, hyperthyroidism, or feeding of metabolic inhibitors [3–6]. Also genetic stress in cellular energy metabolism can evoke significant changes in muscle biogenesis [7].…”

Section: Introductionmentioning

confidence: 99%

Changes in mRNA expression profile underlie phenotypic adaptations in creatine kinase‐deficient muscles

et al. 2001

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We have studied the mechanisms that regulate the remodeling of the glycolytic, mitochondrial and structural network of muscles of creatine kinase M (M-CK)/sarcomeric mitochondrial creatine kinase (ScCKmit) knockout mice by comparison of wild-type and mutant mRNA profiles on cDNA arrays. The magnitudes of changes in mRNA levels were most prominent in M-CK/ScCKmit (CK 3a3 ) double mutants but did never exceed those of previously observed changes in protein level for any protein examined. In gastrocnemius of CK 3a3 mice we measured a 2.5-fold increase in mRNA level for mitochondrial encoded cytochrome c oxidase (COX)-III which corresponds to the increase in protein content. The level of the nuclear encoded mRNAs for COX-IV, H + -ATP synthase-C, adenine nucleotide translocator-1 and insulin-regulatable glucose transporter-4 showed a 1.5-fold increase, also in agreement with protein data. In contrast, no concomitant up-regulation in mRNA and protein content was detected for the mitochondrial inorganic phosphatecarrier, voltage-dependent anion channel and certain glycolytic enzymes. Our results reveal that regulation of transcript level plays an important role, but it is not the only principle involved in the remodeling of mitochondrial and cytosolic design of CK 3a3 muscles. ß

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Section: Introductionmentioning

confidence: 99%

Changes in mRNA expression profile underlie phenotypic adaptations in creatine kinase‐deficient muscles

et al. 2001

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“…In fact, it appears that thyroid status predominates over other potential regulators of MHC isoform expression, such as electrical stimulation (Kirschbaum et al 1990) and mechanical activity (Diffee et al 1991b;Ianuzzo et al 1991). Izumo et al (1986) demonstrated that, in slow muscles, high levels of thyroid hormone are associated with up-regulation of the expression of type II MHC mRNA, whereas chronically low levels of thyroid hormone were associated with up-regulation of type I MHC expression.…”

Section: Effects O Faltered Thyroid Status On Mhc and Mechanical Propmentioning

confidence: 99%

Contractile properties of skeletal muscle fibers in relation to myofibrillar protein isoforms

Moss

Diffee

Greaser

Reviews of Physiology, Biochemistry and Pharmacology

128

124

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Fast-to-slow transformation in stimulated rat muscle

et al. 1996

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Effects of Increased Neuromuscular Activity at Altered Thyroid Hormone Levels on Myosin Expression

Cited by 5 publications

References 0 publications

Changes in mRNA expression profile underlie phenotypic adaptations in creatine kinase‐deficient muscles

Changes in mRNA expression profile underlie phenotypic adaptations in creatine kinase‐deficient muscles

Contractile properties of skeletal muscle fibers in relation to myofibrillar protein isoforms

Fast-to-slow transformation in stimulated rat muscle

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