Effects of incorporation of granule-lyophilised platelet-rich fibrin into polyvinyl alcohol hydrogel on wound healing

Xu, Fangfang; Zou, Dehui; Dai, Taiqiang; Xu, Haiyan; An, Ran; Liu, Yanpu; Liu, Bin

doi:10.1038/s41598-018-32208-5

Cited by 32 publications

(40 citation statements)

References 47 publications

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“…In the past, topical wounds are typically treated and managed with traditional dressings. 35 Xu et al fabricated a novel granule-lyophilised platelet-rich fibrin-loaded polyvinyl alcohol hydrogel scaffolds as an ideal wound dressing material for skin tissue regeneration. Notably, the characterisation studies revealed the excellent morphology, biocompatibility, biodegradability (17-22%), and mechanical strength (6.451×10−2MPa) of this granulelyophilised platelet-rich fibrin loaded polyvinyl alcohol hydrogel scaffolds.…”

Section: Fibrinmentioning

confidence: 99%

Polymeric Hydrogel Scaffolds: Skin Tissue Engineering and Regeneration

et al. 2021

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Tissue engineering is a novel regenerative approach in the medicinal field that promises the regeneration of damaged tissues. Moreover, tissue engineering involves synthetic and natural biomaterials that facilitate tissue or organ growth outside the body. Not surprisingly, the demand for polymer-based therapeutical approaches in skin tissue defects has increased at an effective rate, despite the pressing clinical need. Among the 3D scaffolds for tissue engineering and regeneration approaches, hydrogel scaffolds have shown significant importance for their use as 3D cross-linked scaffolds in skin tissue regeneration due to their ideal moisture retention property and porosity biocompatibility, biodegradable, and biomimetic characteristics. In this review, we demonstrated the choice of ideal biomaterials to fabricate the novel hydrogel scaffolds for skin tissue engineering. After a short introduction to the bioactive and drug-loaded polymeric hydrogels, the discussion turns to fabrication and characterisation techniques of the polymeric hydrogel scaffolds. In conclusion, we discuss the excellent wound healing potential of stem cell-loaded hydrogels and Nano-based approaches to designing hydrogel scaffolds for skin tissue engineering.

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Section: Fibrinmentioning

confidence: 99%

Polymeric Hydrogel Scaffolds: Skin Tissue Engineering and Regeneration

et al. 2021

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“…Interestingly, in contrast to the nontreated group, this study revealed a significant (p < 0.01) fivefold increase in blood vessel density in the LPC group. Recently, Xu et al [15] suggested that the vascularization process was accelerated in their skin wound study in mice after using a scaffold composed of polyvinyl alcohol (PVA) hydrogel and LPCs as a dressing within 9 days post-surgery. Hence, they believe the neo-angiogenesis could provide oxygen and nutrient to the surgical site, thus promoting protein synthesis.…”

Section: Craniofacial Wound Healingmentioning

confidence: 99%

“…Finally, due to the requirement for the need for their use within a short time-frame, as they cannot be easily stored or transported, their application is not well suited for emergency care medicine [14]. These issues restrict the use of PCs for broader therapeutic applications [15].…”

Section: Introductionmentioning

confidence: 99%

Potential of Lyophilized Platelet Concentrates for Craniofacial Tissue Regenerative Therapies

et al. 2021

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Objective: The use of platelet concentrates (PCs) in oral and maxillofacial surgery, periodontology, and craniofacial surgery has been reported. While PCs provide a rich reservoir of autologous bioactive growth factors for tissue regeneration, their drawbacks include lack of utility for long-term application, low elastic modulus and strength, and limited storage capability. These issues restrict their broader application. This review focuses on the lyophilization of PCs (LPCs) and how this processing approach affects their biological and mechanical properties for application as a bioactive scaffold for craniofacial tissue regeneration. Materials and Methods: A comprehensive search of five electronic databases, including Medline, PubMed, EMBASE, Web of Science, and Scopus, was conducted from 1946 until 2019 using a combination of search terms relating to this topic. Results: Ten manuscripts were identified as being relevant. The use of LPCs was mostly studied in in vitro and in vivo craniofacial bone regeneration models. Notably, one clinical study reported the utility of LPCs for guided bone regeneration prior to dental implant placement. Conclusions: Lyophilization can enhance the inherent characteristics of PCs and extends shelf-life, enable their use in emergency surgery, and improve storage and transportation capabilities. In light of this, further preclinical studies and clinical trials are required, as LPCs offer a potential approach for clinical application in craniofacial tissue regeneration.

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“…[ 9 ] To overcome these shortcomings, implantation of platelet-rich fibrin (PRF) has paid greater attention nowadays, to enhance healing. [ 10 ]…”

Section: Introductionmentioning

confidence: 99%

Architectural and ultrastructural variations of human leukocyte-rich platelet-rich fibrin and injectable platelet-rich fibrin

Jasmine¹,

Thangavelu²,

Krishnamoorthy³

et al. 2023

J Microsc Ultrastruct

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Background: Platelet-rich fibrin (PRF) architecture and ultrastructure plays a crucial role in regulating and coordinating the cellular functions and provides a physical architecture, mechanical stability, and biochemical cues necessary for tissue morphogenesis and homeostasis. No study consciously reported the variation in architecture, ultrastructure, and morphology of leukocyte-rich PRF (L-PRF) and injectable PRF (i-PRF). Objective: Hence, the present study was aimed to evaluate the fibrin architecture, ultrastructure, and cell contents of autologous L-PRF and i-PRF. Materials and Methods: The autologous L-PRF and i-PRF were prepared from blood samples of healthy donors. The morphological and structural variations were assessed by histopathology, atomic force microscopy, confocal laser scanning microscope, and field emission scanning electron microscope. Results: Disparity was found on architecture and ultrastructure of L-PRF and i-PRF fibrin network. The variation in platelet and leukocyte concentration attributed to the fibrin conformational changes. L-PRF shows thick fibrins with rough surface, whereas in i-PRF, smooth thin fibrins. Conclusions: The current study revealed that there is heterogeneity between L-PRF and i-PRF fibrin matrix architecture, ultrastructure, platelets, leukocytes, and the fibrin content. These speculate that the diameter, width, roughness, and smoothness of fibrin fibers, pore size, and shapes of L-PRF and i-PRF matrix may initiate and mediate the scaffold functions differently.

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Effects of incorporation of granule-lyophilised platelet-rich fibrin into polyvinyl alcohol hydrogel on wound healing

Cited by 32 publications

References 47 publications

Polymeric Hydrogel Scaffolds: Skin Tissue Engineering and Regeneration

Polymeric Hydrogel Scaffolds: Skin Tissue Engineering and Regeneration

Potential of Lyophilized Platelet Concentrates for Craniofacial Tissue Regenerative Therapies

Architectural and ultrastructural variations of human leukocyte-rich platelet-rich fibrin and injectable platelet-rich fibrin

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