Effects of incorporating acrylolsobutyl polyhedral oligomeric silsesquioxane on the properties of P(N-isopropylacrylamide-co-poly(ethylene glycol) diacrylate) hybrid hydrogels

Xiaoman, Hou; Yang, Wenchao; Li, Aiming; Hou, Jiazi; Zhang, Chunyu

doi:10.1007/s00289-016-1807-z

Cited by 6 publications

(5 citation statements)

References 34 publications

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“…All types of PNIPAM-MAPOSS hybrid hydrogels were prepared by one-step radical polymerization. The synthesis process can refer to our previous work [ 26 ].Briefly, 1 g NIPAM and 0.10 g PEGDA with different proportions of MAPOSS and PEG were dissolved in THF at room temperature. Then 0.01 g AIBN was added to the mixture dispersion with stirring.…”

Section: Methodsmentioning

confidence: 99%

“…We have synthesized a series of MAPOSS-incorporated P(NIPAM- co -PEGDA) hybrid hydrogels in previous work [ 26 ].The introduction of POSS can improve some properties of hydrogels, especially mechanical properties, but this also weakens the water retention. In this paper, PNIPAM was still used as a matrix, a small amount of PEGDA as a crosslinking agent.…”

Section: Introductionmentioning

confidence: 99%

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PNIPAM-MAPOSS Hybrid Hydrogels with Excellent Swelling Behavior and Enhanced Mechanical Performance: Preparation and Drug Release of 5-Fluorouracil

Xiaoman

et al. 2018

Polymers

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Poly(N-isopropylacrylamide) (PNIPAM) is a widely-studied polymers due to its excellent temperature sensitivity. PNIPAM-MAPOSS hybrid hydrogel, based on the introduction of acrylolsobutyl polyhedral oligomeric silsesquioxane (MAPOSS) into the PNIPAM matrix in the presence of polyethylene glycol, was prepared via radical polymerization. The modified hydrogels exhibited a thick, heterogeneous porous structure. PEG was used as a pore-forming agent to adjust the pore size. MAPOSS reduced the swelling ratios of gels, and decreased the LCST, causing the hydrogels to shrink at lower temperatures. However, its hydrophobicity helped to improve the temperature response rate. The incorporation of rigid MAPOSS into the polymer network greatly increased the compressive modulus of the hydrogel. It is worth noting that, by adjusting the amount of MAPOSS and PEG, the hydrogel could have both ideal mechanical properties and swelling behavior. In addition, hydrogel containing 8.33 wt % MAPOSS could achieve stable and sustained drug release. Thus, the prepared PNIPAM-MAPOSS hybrid hydrogel can serve as drug carrier for 5-fluorouracil and may have potential application in other biomedical fields.

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

PNIPAM-MAPOSS Hybrid Hydrogels with Excellent Swelling Behavior and Enhanced Mechanical Performance: Preparation and Drug Release of 5-Fluorouracil

Xiaoman

et al. 2018

Polymers

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“…Zheng et al achieved the incorporation of MAPOSS into the PNIAAM system by copolymerization with NIPAM and BIS via AIBN-initiated FRP at 60 °C, where POSS were regarded as nanoporogens and the hydrogels exhibited a performance quite similar to those modified with octafunctional POSS . Also, BIS in this work could be replaced by frequently used PEGDMA or other effective chemical crosslinkers . Furthermore, Romo-Uribe et al waived chemical crosslinkers and investigated the pure physical hydrogels derived from MAPOSS and PNIPAM. , The thermoplastic copolymers were capable of thermoforming at high temperature, followed by hydration to hydrogels.…”

Section: Construction Of Poss-containing Hydrogelsmentioning

confidence: 99%

“…83 Also, BIS in this work could be replaced by frequently used PEGDMA or other effective chemical crosslinkers. 84 physical hydrogels derived from MAPOSS and PNIPAM. 85,86 The thermoplastic copolymers were capable of thermoforming at high temperature, followed by hydration to hydrogels.…”

Section: Monofunctional Poss As An End-capmentioning

confidence: 99%

Polyhedral Oligomeric Silsesquioxanes (POSS)-Based Hybrid Soft Gels: Molecular Design, Material Advantages, and Emerging Applications

Shi

Yang

You

et al. 2020

ACS Materials Lett.

105

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Polyhedral oligomeric silsesquioxanes (POSS) represent the new frontier in hybrid materials science and engineering, because of their well-defined nanostructure and unique dual nature combining material properties from both inorganic siloxane cage and organic groups at the periphery. Recent advances in synthetic chemistry, combined with the controlled radical polymerization techniques, have significantly influenced the construction of POSS soft gel as emerging biomaterials and beyond. In this Review, the most recent developments in the design strategies of POSS-based hybrid soft gels are presented, with respect to different functions of architectural POSS, including POSS as a crosslinker, end-cap polymer chain, pendent group, etc. In addition, the insights into the uniqueness of POSS in microstructure and their different organic substituents in the enhancement of the hydrogel performance are illustrated. These sophisticated materials with multiple functions, oriented toward advanced therapeutic applications, are further summarized into several active domains in controlled drug delivery, 3D cell culture, tissue engineering, and wound healing. The recent new applications of using POSS hybrid soft gel in environmental health are also summarized in this Review. Finally, perspectives and challenges related to the further advancement of POSS-based hybrid soft gel materials are discussed.

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“…POSS-PNIPAM hybrid hydrogels have been reported by several groups. [40][41][42] For example, Zheng et al constructed the POSS-PNIPAM hydrogels via physical crosslinking using POSS-capped PNIPAM telechelics. 41 Here, the PNIPAM based hydrogels were prepared via chemical photo-crosslinking with Irgacure 2959 as an initiator and OMAPOSS as a cross-linker.…”

Section: Synthesis and Characterization Of Poss-pnipam Hybrid Hydrogelsmentioning

confidence: 99%

POSS-enhanced thermosensitive hybrid hydrogels for cell adhesion and detachment

et al. 2018

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Effects of incorporating acrylolsobutyl polyhedral oligomeric silsesquioxane on the properties of P(N-isopropylacrylamide-co-poly(ethylene glycol) diacrylate) hybrid hydrogels

Cited by 6 publications

References 34 publications

PNIPAM-MAPOSS Hybrid Hydrogels with Excellent Swelling Behavior and Enhanced Mechanical Performance: Preparation and Drug Release of 5-Fluorouracil

PNIPAM-MAPOSS Hybrid Hydrogels with Excellent Swelling Behavior and Enhanced Mechanical Performance: Preparation and Drug Release of 5-Fluorouracil

Polyhedral Oligomeric Silsesquioxanes (POSS)-Based Hybrid Soft Gels: Molecular Design, Material Advantages, and Emerging Applications

POSS-enhanced thermosensitive hybrid hydrogels for cell adhesion and detachment

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